4 ms·
This is actually not totally correct. AAV’s form episomes, which are circular DNA structures that are basically extra chromosomes. The fact that AAV’s don’t ran
by bglazer 2y ago
This is actually not totally correct. AAV’s form episomes, which are circular DNA structures that are basically extra chromosomes. The fact that AAV’s don’t randomly insert themselves into DNA makes them safer for clinical uses like this.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519600/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519600/
- toufka 2y agoAnd that’s why replies are helpful in these kind of explanations. My over-edits became wrong, and then an hour later, unfixable. bglazer is correct. AAVs, unlike Lentiviruses, do NOT integrate.
- bglazer 2y agoThe reason I know this is I made the same mistake in a comment on a similar story a few weeks ago!