COGlory

51 ms·

691.
by COGlory 5y ago
Is exporting your passwords and encrypting the file not an option for you?
692.
by COGlory 5y ago
"If the other party wins, it's not democracy."
693.
by COGlory 5y ago
This was hilarious, thanks for sharing.
694.
by COGlory 5y ago
How do you know it's misinformation? Or are you just taking someone elses word for it?
695.
by COGlory 5y ago
It's not a semantic difference. That's the problem. There is a difference between knowledge of protein folding (which is what the article is talking about), i.e. understanding proteins well enough to predict how they will fold, an
696.
by COGlory 5y ago
You may be interested in this: https://pubmed.ncbi.nlm.nih.gov/30237357/ Programmable protein circuits in living cells
697.
by COGlory 5y ago
As a structural biologist, I have to ask, how did you draw that from this? > seemed possible that the three-dimensional structure of a protein could be predicted based on the sequence of its amino acids. That simply is not what AlphaFold
698.
by COGlory 5y ago
>This “protein-folding problem,” as it came to be known, baffled scientists until this year, when the papers we’ve deemed the 2021 Breakthrough of the Year were published. This is a straight lie and the author should be embarrassed. Ther
699.
by COGlory 5y ago
No, because there's little to no training data, and the neural network doesn't appear to actually have any real information on protein folding physics, beyond just very advanced template matching.
700.
by COGlory 5y ago
>It really doesn't seem like you are well versed on this topic. I don't know any other way to put it. Ok. I am, but I don't expect you to take my word for it. >alphafold's 90% is 90% because that is the highest pos
701.
by COGlory 5y ago
Ok, how about the featured article? Or the CASP competition? Or posted further up: https://www.science.org/content/blog-post/more-protein-foldi... Or take the RMSD of a superposition of any two identical structur
702.
by COGlory 5y ago
Yes, click on my bio. I'm a PhD structural biologist.
703.
by COGlory 5y ago
>For us to be sure, it is necessary to repeat some crystallographies and/or find a better method to produce these labels. We have this information. And we've had it for decades. There's hundreds of duplicate structures on
704.
by COGlory 5y ago
Those factors do figure in, and AlphaFold has no way to address them, mainly because it's more a pattern matching algorithm than a protein fold computer. Experimental methods are also quite poor at addressing them.
705.
by COGlory 5y ago
I too am using AlphaFold when I can, and it is immensely valuable as a tool. The same way Phyre and ITASSER were immensely valuable. But it still suffers from the same categorical limitations that all homology modeling suffers from (althoug
706.
by COGlory 5y ago
Could you enlighten me of my ignorance on the topic?
707.
by COGlory 5y ago
I think my problem with the AlphaFold narrative is that it's being treated as if it's something new, or that (as I see frequently) "protein folding is solved". As far as I can tell, our knowledge of protein folding hasn&
708.
by COGlory 5y ago
>Hard disagree. It's common knowledge, and was even mentioned in this fluff article, 90% accuracy is within the experimental error of the "truth set". It's entirely possible alphafold is more accurate then the X-ray c
709.
by COGlory 5y ago
>considering protein structure was/is often named as the “holy grail” of computational biology, and homology was always the method to get there Homology is never considered "solving the protein folding problem". It's
710.
by COGlory 5y ago
Alphafold is interesting, but not a particularly big deal. It's just better homology modeling at the end of the day, and the difference between 60% and 90% is a lot less critical than the difference between 90% and 100%. Those I have t
711.
by COGlory 5y ago
Yeah this is pretty bad. Not really sure what to say beyond that. I'm extremely confused how anyone thought this was OK.
712.
by COGlory 5y ago
I work daily with 70% ethanol for sanitizing, and 95% ethanol for cleaning. I can never get the 70% stuff to light. Even with an open flame. By the way, most hand sanitizer is around 70% or less. Above 70% and it doesn't kill bacteria
713.
by COGlory 5y ago
I left Fi because I was very concerned about something like this
714.
by COGlory 5y ago
From May this year
715.
by COGlory 5y ago
Professional organizations are extremely effective gatekeeping mechanisms.
716.
by COGlory 5y ago
Sorry - run on sentences made it unclear. My mentor is the friend. I'm the one that's never interacted
717.
by COGlory 5y ago
If anyone is interested in further reading on this topic, or on evolution/origin of life in general, I highly recommend "The Logic of Chance" by Eugene Koonin. The book pieces together the latest knowledge from all the major
718.
by COGlory 5y ago
Advertisers could pay to get unblocked. https://blogs.cornell.edu/info2040/2016/09/15/justin_kuang_a...
719.
by COGlory 5y ago
The real feat there was economic. Scientifically, that technology is quite mature
720.
by COGlory 5y ago
The FTC mentioned chips in vehicles multiple times. >The FTC’s complaint alleges that the combined firm would have the means and incentive to stifle innovative next-generation technologies, including those used to run datacenters and dri

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