>considering protein structure was/is often named as the “holy grail” of computational biology, and homology was always the method to get there Homology is nev

>considering protein structure was/is often named as the “holy grail” of computational biology, and homology was always the method to get there Homology is never considered "solving the protein folding problem". It's 100% based off of past data which incorporates all sorts of biases, including as others have pointed out, experimental error. For instance, in my field, where there is terrible amino acid sequence conservation, AlphaFold is just as poor at prediction as existing solutions like Phyre.