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Pay No Attention to the Bloody Corpse in the Bathroom
- wavefunction 13y agoNot to blow up my own spot but the bit about GHB being a powerful CNS depressant is just as true about alcohol and it strikes me as a bit dramatic. There are reasons why researchers are interested in pursuing it as a potentially helpful tool for opium addicts, and focusing on the prurient aspects of a substance is exactly what makes research into _controlled_ therapeutic use of GHB or Cannabis or psilocybin so hard to do in this country.
- nknighthb 13y ago> the bit about GHB being a powerful CNS depressant is just as true about alcohol In the US, a "standard drink" is 14 grams of pure alcohol. It's the equivalent of a typical can of beer. 3.5 grams of GHB can trigger unconsciousness, and 7 grams is potentially lethal. If this is "just as true", I think our definitions of truth are wildly different. EDIT: If you feel the need to reply to this comment, please read the entire thread first and realize there's nothing "between the lines" of the comment. I have no agenda here. I'm not making a policy argument. I'm not advocating for or against GHB or any other substance. You don't need to tell me what the LD50 is for any particular substance (chances are I already know).
- threedaymonk 13y agoPotency is a pretty misleading comparison. There are drugs that are prescribed in μg (mcg) doses, and drugs that are prescribed in mg - mistaking μg for mg has caused deaths. The LD50 of caffeine for an average male is about 14 g. That's the same (in terms of mass) as the alcohol in a beer. Does that make caffeine more or less "powerful"? It takes something like a hundred cups of coffee to reach caffeine's LD50; for alcohol, it's slightly over one bottle of strong spirits. Despite caffeine's higher potency, it's a lot easier to kill yourself by drinking too much whisky than too much coffee.
- nknighthb 13y agoI cannot begin to understand what point you're trying to make. The person I was replying to was explicitly comparing the potency of GHB to alcohol, both depressants commonly encountered in a highly concentrated form. Making this about caffeine or any other substance that can be lethal in small amounts seems a non-sequitur.
- mikeash 13y agoThe point is that what we generally consider as "power" or "potency" is more than just effect per unit mass. We don't generally consider capsaicin to be more powerful than alcohol even though, purely on the basis of how much you have to ingest, it's far easier to kill yourself with it.
- nknighthb 13y ago> what we generally consider as "power" or "potency" is more than just effect per unit mass Um, OK, that may be true for you, and maybe even for society at large, but I've personally never heard such a thing before right now. It's certainly not how I would define the words. To address the point I think you're trying to make (which still doesn't make much sense to me), in the forms they are commonly encountered in, GHB is unquestionably much more dangerous/"powerful" than alcohol. So I still don't see why my comment attracted this sort of argument.
- pstuart 13y ago> much more dangerous Only if taking the same amounts, which is ludicrous. Alcohol is plenty dangerous already and we're all ok with that.
- nknighthb 13y agoI think you think I'm making some sort of profound safety and/or merits-of-substance and/or political argument. I'm really not. Edit: Regardless, I surrender, this conversation is both useless and utterly uninteresting because nobody is talking about the same thing I am. I deeply regret having entered it.
- wavefunction 13y agoWell, a "dose" of GHB is more like 1 gram or less, so I'm not talking about equivalency by weight. Now I really am blowing up my spot ;) I should also note my experience was back in the 90s when it was still legal in my locale
- mikeash 13y agoJust comparing quantities isn't all that useful. Availability needs to be compared, and how much one would "usually" take. With 7 grams being potentially lethal, it's roughly similar to Tylenol (not recommended to exceed 4 grams), caffeine (foolishly extrapolating the LD50 in rats to a human puts the lethal dose at around 10 grams), aspirin (similar to caffeine), and a lot better than capsaicin (foolishly extrapolated lethal dose around 2 grams).
- nknighthb 13y agoSince you and threedaymonk both seem to be making a similar argument that makes absolutely no sense to me in context, I'll just point you at my reply to him.
- peteretep 13y agoYour head is liable to E-X-P-L-O-D-E when you hear that there's a drug for sale - nationwide - that's a CNS depressant, where 1 gram of is FATAL. Can you believe that? And yet they sell this thing called "nicotine" to people as young as 16! Perhaps effect per weight is a shitty measure?
- nknighthb 13y agoUgh. I was going to just step out, but I can't let this pass, because it's incredibly insulting. I'm not arguing for the banning of a substance. I'm not arguing one substance is subjectively better than another. I don't care that GHB or any other drug is being used in studies. You're reading something into my comments that simply is not there. Please stop it.
- peteretep 13y agoWhat was your comment about then? You appear to be comparing simply effect per weight, and drawing conclusions from that?
- nknighthb 13y agoMy comment was about what was, in my view, an objectively inaccurate characterization of alcohol being "just as powerful" a CNS depressant as GHB. That is all it was. If you want to argue about something else, I'm not the opponent you're looking for.
- peteretep 13y agoIf you were right, people would routinely refer to nicotine as being the most powerful street drug, given it's punch-per-gram ratio.
- nknighthb 13y agoYes, it turns out that my use of "power" and "potent" as synonyms is not universal. My deepest apologies for my inexcusably moronic assumption that people used a particular word the same way I do. Are we done now?
- malandrew 13y agoI also found that part very dramatic as someone who has a GHB prescription for cataplexy. Does the drug have a checkered past? Yes, but a lot of the public sentiment towards it is the result of journalistic histrionics. For years it was sold over the counter at GNC to body builders because of its impact on prolactin levels in the body, and AFAIK it is the only known substance that mimics natural sleep. It improves REM sleep and stages 3 & 4 of slow-wave sleep. I myself have one of the few known cases of very very mild cataplexy, so I don't absolutely have to have GHB to function, but for most people who also test positive for the HLA marker DQB1*0602 and have severe cataplexy, GHB is an absolute life saver. These people don't really experience and long term psychological effects as would be implied by the scare words used in the paragraph describing GHB. Yes, it has powerful CNS depressive effects and can be lethal in high doses, but those effects are pretty much only applicable while under the influence of the drug and not after your body has metabolized it and flushed it from the body.
- saalweachter 13y agoReading the backs and forths of various drugs and medical treatments over the years has left me with two overall lessons: * A drug with horrific potential side effects can be worth it, if the condition it is treating is worse. For instance, a drug which can cause strokes might be worth it to prevent horrible seizures, but not to prevent mild hay fever. * Even if a drug can be abused, it doesn't change the fact that some people legitimately need it. You see this most in pain management, where people who need powerful pain killers just to function face criminal charges and roadblocks to getting the medicine they need.
- mcguire 13y agoTechnically, though, you are supposed to get informed consent from the subjects. The link from the article: http://www.scribd.com/doc/114822452/Halikas-Scandal-News-Reports http://www.scribd.com/doc/114822452/Halikas-Scandal-News-Rep...
- coldcode 13y agoNo matter how much amazing technology we develop the amazing ability of people to rationalize evil remains unimproved.
- fnordfnordfnord 13y agoSome background, which may have even appeared on HN before. Markington, the suicide victim, was coerced to join the study through a dubious sounding scheme. "Dan was acutely psychotic, plagued by delusions about demons, and he had repeatedly been judged incapable of making his own medical decisions. Even worse, he had been placed under an involuntary commitment order that legally compelled him to obey the recommendations of the psychiatrist who recruited him into the study." http://www.minnpost.com/community-voices/2013/03/why-university-minnesota-psychiatric-research-scandal-must-be-investigated http://www.minnpost.com/community-voices/2013/03/why-univers...
- chewxy 13y agoThis ethical question is particularly interesting. Just to play Devil's Advocate, let's assume that Big Pharma is not involved. Rather, the people who are doing the research are honest researchers who gain utility through the act of research and finding breakthroughs. If phrased this way, the incidents may suddenly now be sympathized as being yet another statistic - after all, sacrifices must be made in the name of scientific progress. The matter of coercion becomes trivial in the sense of The Greater Good (of course, not all research will yield positive results, and that's the whole point of research). Now, if one were to have this sort of view going into doing medical trials, who's to say that one's wrong? Why is it still evil, if the net result are better drugs to control one's moods?
- neekb 13y agoI think the article called to mind some other issues that were more important than the debate about how ethical studies like this are or are not. This guy's mother was giving the researchers feedback that the participant could not. Namely, that he was getting WORSE. She tried to have him removed from the program, and apparently couldn't. That goes well beyond "yet another statistic", especially as he was deemed incapable of making his own medical decisions.
- lprubin 13y agoTo me what's evil is the stonewalling of an investigation into the death.
- stonemetal 13y agoHaving only read the linked article, I have no opinion on how valid the research was. The primary concern is that people have died in a way that points to the research program in question having been a contributing factor, and the fact that there wasn't even a cursory investigation to make sure things are on the up and up.
- mcguire 13y ago"The matter of coercion becomes trivial in the sense of The Greater Good (of course, not all research will yield positive results, and that's the whole point of research)." Not really. There are historical reasons why informed consent is a requirement. Put another way, would you feel the same if you were the one being coerced? How would you feel about an untreated syphilis infection?
- edlebert 13y agoSounds like a job for Dexter.
- brown9-2 13y agoOne of the most baffling parts of this story might be the reference to the university's statutory immunity. Is that really a thing?
- mcguire 13y agoThe University of Minnesota, if it's like the other "public" universities in the U.S. that I'm familiar with, is officially, more-or-less, when-it-wants-to-be-ish, a branch of the government of the state of Minnesota. "Sovereign immunity" extends to the university.
- LatvjuAvs 13y agoMaybe he really "Left this experience smiling"?
- e40 13y agoThe petition has a very small number of signers. Perhaps we can help out there. https://www.change.org/petitions/governor-mark-dayton-of-minnesota-investigate-psychiatric-research-misconduct-at-the-university-of-minnesota-2 https://www.change.org/petitions/governor-mark-dayton-of-min...
- coinbase-craig 13y agoMy question is why is it up to the facility to investigate? Shouldn't there be a police investigation? Why's that not happening?
- api 13y agoWhen institutions behave like this they're not just tarnishing their own image. They're destroying civilization. Got into a debate around here a while back trying to explain why otherwise-rational people are afraid of GMO foods. This is an example of my point. Things like this erode trust not just in the particular institution in question but of all institutions in our society. At some point many people actually start to assume the worst and flip over into seeing official pronouncements as contrarian indicators: "oh, the paid shills say it's safe and it's produced by a big agribusiness corporation so it must be bad for you..." Even worse still, we have junk like this: https://www.scientificamerican.com/article.cfm?id=moon-landing-faked-why-people-believe-conspiracy-theories https://www.scientificamerican.com/article.cfm?id=moon-landi... I've seen a rash of these articles lately, deconstructing in elaborate detail why people distrust science and officialdom and believe in increasingly outlandish "conspiracy theories." They're all elaborate dances to avoid the obvious issue: trust. It's almost a kind of blame-the-victim mentality: yes you have been lied to, but you should ignore that. If the fact that you've been treated contemptuously causes you to begin harboring suspicions, it's because you are irrational and stupid. Now shut up and believe what you're told. No, it's not the victim's fault. It is the authorities' fault. Trust is earned through consistent transparency and honorable behavior. When the institutions of society behave dishonorably and unethically, trust is systematically weakened across the entire society. Once a person learns that their authorities may well be shills, liars, quacks, fools, or worse, then it becomes increasingly easy to harbor increasingly-damning suspicions about what else "they" might be lying about. Hence 9/11 was an inside job, moon hoax, and other conspiracy theories. Keep in mind that sometimes such suspicions are correct. The executive branch lied the US into war in Iraq, to give one example. With examples of that magnitude, I personally question whether belief in outlandish conspiracy theories is even particularly irrational. And it's very, very dangerous. Trust is one of the key differences between the first world and the third world. Part of why places like sub-Saharan Africa can never develop is that nobody trusts anyone and nobody dares do anything. They "know" (and sometimes with good reason) that anything they do will simply be stolen by their kleptocracies, and that anything their authorities say is probably a lie. (Hence the prevalence of things like HIV/AIDS denialism in those cultures... another symptom of decayed trust.) If our leaders, authorities, and institutions continue to treat the public with dismissive contempt, the third world is where we are headed. The prevalence of conspiracy theories and alt-health fearmongering is a leading indicator of an overall breakdown in the implicit trust relationships and social contract that underlies advanced Western societies.
- lazugod 13y agoIs Medium.com teaching classes on informationless, sensationalized headlines or something?
- fixxer 13y agoWhat really gets me about this, beyond the tragedy itself, is the amount of bullshit I have had to go through to get IRB approval for completely insignificant projects (monitoring decibel levels in public spaces, for example, which is NOT even subject to IRB exemption but I still was forced by the funding source to pursue). Ugh.
- lucidrains 13y agoRecently one of the pediatric residents at my hospital was found watching child pornography in the call room. After being reported, the institution did nothing about it, and tried to sweep it under the rug. It bothers me that a prestigious academic institution would rather save face than to deal with a serious issue at hand.
- mixmastamyk 13y agoCall the police and/or social services. The article doesn't mention the police either, wtf? Surely they did an investigation?
- gchpaco 13y agoJurisdiction is funny on universities. UCSB (one I have personal experience with) has a special campus police branch that overlaps somewhat with the Isla Vista branch but are nominally distinct; I don't think the county's sheriff's department has any jurisdiction there.
- DanBC 13y agoDepending on the country many of the workers there will have a legal duty to report that incident. They'll also have requirements from their professional registrations.
- kevinnk 13y agoAssuming we're talking about the "other" UofM, I would hardly call what happened "doing nothing about it." It was almost certainly an egregious failure on the part of a couple individuals, but it was more about a lapse in protocol then a university cover up. Not to mention that UofM has completed two separate independent reviews of what happened and made a pretty big (and public) effort to fix it.
- lucidrains 13y agoThe version I heard among my colleagues was that only after the police was brought in did the university sped up it's investigations.
- brightghost 13y agoI can't claim to be well-versed on this story, but I would like to point out that a couple weeks ago the author of this piece was accused of misrepresenting the issue in the local paper, The Star Tribune. In particular he was called out for glossing over the fact that there have already been several investigations of the matter, which I see he has again failed to mention in the piece linked here. http://www.startribune.com/local/yourvoices/207993521.html http://www.startribune.com/local/yourvoices/207993521.html
- SilasX 13y agoActually he mentions it: >>University officials have repeatedly claimed to have been investigated and exonerated by various legal and regulatory bodies, but those claims have fallen apart. And has these links: http://www.healthnewsreview.org/2013/05/questions-journalists-should-ask-about-a-psych-drug-trial-suicide/ http://www.healthnewsreview.org/2013/05/questions-journalist... http://www.scribd.com/doc/147683397/Attorney-General-Office-Letter-Refuting-Claim-That-It-Investigated-Markingson-Death http://www.scribd.com/doc/147683397/Attorney-General-Office-...