10 ms·

From that list 48.17% of all health care R&D spend is by US based companies. Sounds like the US is subsidizing the world to me.

alive-or-not 14y ago
Health care R&D is extremely expensive in US (insanely high executive salaries, "lobbing" expenses, etc.). US companies may spend as much as the rest of the world, but deliver a lot less innovation.
- adventured 14y ago
  I don't see any evidence to support your very dramatic claim. Quite the opposite. From early chemotherapy on to the human genome, stem cells, the Allen Brain Atlas, The Gates Foundation, modern biotechnology, organ regrowth, medical devices like the CT scanner (half invented in the US) or the da Vinci system of robotic surgery, etc etc etc the modern healthcare / pharma / biotech world owes a spectacularly massive debt to the US. To say nothing of the surrounding infrastructure everything requires related to technology from the microprocessor to the Internet. How much did that tech speed up R&D, try quantifying that little contribution.
  - analog 14y ago
    And all of that surrounding infrastructure is reliant on Mathematics which didn't originate in the US.
    - fredsanford 14y ago
      Such a useless comment. Mathematics was arrived at by research which everyone shared when the vast majority of the research was happening...
      - analog 14y ago
        I'm not sure why it's useless. If you're going to account for value provided by external sources then account for all sources, not just the ones that support your argument.
        fredsanford 14y ago
        For what are you accounting? Most mathematics has been known about for 100+ years... IMO, This comment was a reason for you to hear yourself "talk" or alternatively for you to take a (weak) shot at the U.S.
        analog 14y ago
        Lets see, mathematics[1], language[2], writing[3], the printing press[4], scientific method[5]. Each of these innovations are absolutely required for the innovation that pharma companies produce, and none originated in the US. Your 100 year cut-off point is entirely arbitrary and chosen only because it supports your arguments. [1] http://en.wikipedia.org/wiki/History_of_mathematics http://en.wikipedia.org/wiki/History_of_mathematics [2] http://en.wikipedia.org/wiki/Origin_of_language http://en.wikipedia.org/wiki/Origin_of_language [3] http://en.wikipedia.org/wiki/History_of_writing http://en.wikipedia.org/wiki/History_of_writing [4] http://en.wikipedia.org/wiki/Printing_press http://en.wikipedia.org/wiki/Printing_press [5] http://en.wikipedia.org/wiki/History_of_scientific_method http://en.wikipedia.org/wiki/History_of_scientific_method
  - omd 14y ago
    Such a useless comment. Everything you mentioned was arrived at by research which everyone shared when the vast majority of the research was happening...
  - ewoodrich 14y ago
    "The Human Genome Project (HGP) is an international scientific research project with a primary goal of determining the sequence of chemical base pairs which make up DNA, and of identifying and mapping the approximately 20,000–25,000 genes of the human genome from both a physical and functional standpoint.[1] The first official funding for the Project originated with the Department of Energy’s Office of Health and Environmental Research, headed by Charles DeLisi, and was in the Reagan Administration’s 1987 budget submission to the Congress.[2] It subsequently passed both Houses. The Project was planned for 15 years.[3] " I don't see how the HGP was unrelated to government investment...
    - streptomycin 14y ago
      He didn't say it was unrelated to government involvement, he said it's one of many examples of how the US private sector has delivered innovation. See Celera's role in sequencing the human genome. http://en.wikipedia.org/wiki/Celera_Corporation http://en.wikipedia.org/wiki/Celera_Corporation "Celera's use of the shotgun strategy spurred the public HGP to change its own strategy, leading to a rapid acceleration of the public effort."
bergheim 14y ago
By that logic, you should add the population for the other countries and compare to the US, which is about 345m compared to the US, 315m - which doesn't sound like the US is "subsidizing the world" to me.. Although I guess a big chunk of that revenue probably comes from the US.
- forrestthewoods 14y ago
  No you shouldn't. Your 345m is heavily weighted by Japan's 127m population which accounts for 2.3% of the research spend from the chart in question. If you want to play that game then Japan is incredibly subsidized by the US and Europe, but that's not the question at hand. :)
ofacup 14y ago
keep on believing. you're the defender of freedoms after all
- adventured 14y ago
  That's embarrassing. What does your glib, mostly obnoxious comment have to do with anything factual? You hate America so much you can't even give it credit for positive things that are factually accurate?
  - jezfromfuture 14y ago
    Sorry but america does not subsidise the health systems of the world , it just sad to see you argue so much when in all actuality your being fleeced tax payer wise & health insurance wise . Your health service doesn't really seem like its there to help most just the rich people.
  - omd 14y ago
    I knew it was just a matter of time before American xenophobia came to HN.
  - ofacup 14y ago
    i'm sorry, but i'm not embarrassed. please show me where your "mostly obnoxious comment" has anything to do with anyone. the usa does not subsidise world healthcare. get over yourself
- geebee 14y ago
  I believe that the thesis was that health care companies make heavy investments in R&D that are only profitable because of very high prices in the US, and that these innovations probably wouldn't be available at the lower cost in other other countries without this profit center. That's just a thesis. It's an interesting one, I'd be interested in reading some discussion of it, especially insightful comments backed with data.
coldtea 14y ago
Or that US health research produces far less bang for the buck, because the companies can charge whatever they want, and the suckers (citizens) have to bend over and cough up the money.
belorn 14y ago
It should also be mentioned (since we are talking about statistics here), that 1/3 of the total US medical research spending is from taxes (congress) and has been consistently been so for 20-30 years. That money has no connections with the current health care system, or insurance companies and is just pure tax money sent into research. From those 1/3, about 95% of all core research is supported, and around 80% of all research into medical conditions that are life threatening. Health care system, insurance companies and patents are for everything else... *The 95% and 80% is number from a talk, and for the moment I can't find references. What I could find is statements about majority funding is used on basic research (http://jama.jamanetwork.com/article.aspx?articleid=205216 http://jama.jamanetwork.com/article.aspx?articleid=205216 and http://www.nsf.gov/statistics/seind12/c5/c5s1.htm http://www.nsf.gov/statistics/seind12/c5/c5s1.htm). In the future I will hold off on those number in comments until I got direct sources to use with them.
- kingkawn 14y ago
  If true these stat provide a compelling point of argument for expanded government research funding and less protection for the private insurance system. Do you have a source for it?
  - criley 14y ago
    I'd be interested as well, because if he's trying to label all NIH-bound funds as imperative to this process, I think he's overstating his case. Yes, academic institutions do a lot of low level work that pharma companies build on top of, but you'd be surprised how often potential new molecular entities (truly new drugs) do not originate from government sponsored academic sources. (However, the tools, understanding and/or methodologies that made that new NME possible did likely come from those labs!)
    - belorn 14y ago
      One can read the data in different ways, and I don't think anyone doubt that pharma companies do contribute to the investments into new medical innovations. One interpretation that I listen/read about is that NiH and pharma operate on different levels, and thus sadly, NiH's contribution tend to be forgotten because they aren't the people with that pop out the pills bought in the store, even if the pills would not have existed if it hadn't been for the NiH funded research that made the new innovation possible. Then we add patents and insurance companies into the mix, and some people want to paint a picture how innovation gets created. My comment was thus mostly to inform that the largest single funder to medical research is not some for-profit company like Pfizer, but rather tax supported NiH.
baldfat 14y ago
Only profitable drugs. Pediatric Cancer is not one of them so no new Chemotherapy in the US for over 20 years now and counting. Also manufacturing is stupid also. Only one company makes Oxycodone (Pain Killer) there use to be two companies. Now the price has sky rocked and can be in short supply. So my son suffered for a few days due to not getting all the pills he needed. Great system.

alive-or-not 14y ago

Health care R&D is extremely expensive in US (insanely high executive salaries, "lobbing" expenses, etc.). US companies may spend as much as the rest of the world, but deliver a lot less innovation.

adventured 14y ago
I don't see any evidence to support your very dramatic claim. Quite the opposite. From early chemotherapy on to the human genome, stem cells, the Allen Brain Atlas, The Gates Foundation, modern biotechnology, organ regrowth, medical devices like the CT scanner (half invented in the US) or the da Vinci system of robotic surgery, etc etc etc the modern healthcare / pharma / biotech world owes a spectacularly massive debt to the US. To say nothing of the surrounding infrastructure everything requires related to technology from the microprocessor to the Internet. How much did that tech speed up R&D, try quantifying that little contribution.
- analog 14y ago
  And all of that surrounding infrastructure is reliant on Mathematics which didn't originate in the US.
  - fredsanford 14y ago
    Such a useless comment. Mathematics was arrived at by research which everyone shared when the vast majority of the research was happening...
    - analog 14y ago
      I'm not sure why it's useless. If you're going to account for value provided by external sources then account for all sources, not just the ones that support your argument.
      - fredsanford 14y ago
        For what are you accounting? Most mathematics has been known about for 100+ years... IMO, This comment was a reason for you to hear yourself "talk" or alternatively for you to take a (weak) shot at the U.S.
        analog 14y ago
        Lets see, mathematics[1], language[2], writing[3], the printing press[4], scientific method[5]. Each of these innovations are absolutely required for the innovation that pharma companies produce, and none originated in the US. Your 100 year cut-off point is entirely arbitrary and chosen only because it supports your arguments. [1] http://en.wikipedia.org/wiki/History_of_mathematics http://en.wikipedia.org/wiki/History_of_mathematics [2] http://en.wikipedia.org/wiki/Origin_of_language http://en.wikipedia.org/wiki/Origin_of_language [3] http://en.wikipedia.org/wiki/History_of_writing http://en.wikipedia.org/wiki/History_of_writing [4] http://en.wikipedia.org/wiki/Printing_press http://en.wikipedia.org/wiki/Printing_press [5] http://en.wikipedia.org/wiki/History_of_scientific_method http://en.wikipedia.org/wiki/History_of_scientific_method
- omd 14y ago
  Such a useless comment. Everything you mentioned was arrived at by research which everyone shared when the vast majority of the research was happening...
- ewoodrich 14y ago
  "The Human Genome Project (HGP) is an international scientific research project with a primary goal of determining the sequence of chemical base pairs which make up DNA, and of identifying and mapping the approximately 20,000–25,000 genes of the human genome from both a physical and functional standpoint.[1] The first official funding for the Project originated with the Department of Energy’s Office of Health and Environmental Research, headed by Charles DeLisi, and was in the Reagan Administration’s 1987 budget submission to the Congress.[2] It subsequently passed both Houses. The Project was planned for 15 years.[3] " I don't see how the HGP was unrelated to government investment...
  - streptomycin 14y ago
    He didn't say it was unrelated to government involvement, he said it's one of many examples of how the US private sector has delivered innovation. See Celera's role in sequencing the human genome. http://en.wikipedia.org/wiki/Celera_Corporation http://en.wikipedia.org/wiki/Celera_Corporation "Celera's use of the shotgun strategy spurred the public HGP to change its own strategy, leading to a rapid acceleration of the public effort."

bergheim 14y ago

By that logic, you should add the population for the other countries and compare to the US, which is about 345m compared to the US, 315m - which doesn't sound like the US is "subsidizing the world" to me.. Although I guess a big chunk of that revenue probably comes from the US.

forrestthewoods 14y ago
No you shouldn't. Your 345m is heavily weighted by Japan's 127m population which accounts for 2.3% of the research spend from the chart in question. If you want to play that game then Japan is incredibly subsidized by the US and Europe, but that's not the question at hand. :)

ofacup 14y ago

keep on believing. you're the defender of freedoms after all

adventured 14y ago
That's embarrassing. What does your glib, mostly obnoxious comment have to do with anything factual? You hate America so much you can't even give it credit for positive things that are factually accurate?
- jezfromfuture 14y ago
  Sorry but america does not subsidise the health systems of the world , it just sad to see you argue so much when in all actuality your being fleeced tax payer wise & health insurance wise . Your health service doesn't really seem like its there to help most just the rich people.
- omd 14y ago
  I knew it was just a matter of time before American xenophobia came to HN.
- ofacup 14y ago
  i'm sorry, but i'm not embarrassed. please show me where your "mostly obnoxious comment" has anything to do with anyone. the usa does not subsidise world healthcare. get over yourself
geebee 14y ago
I believe that the thesis was that health care companies make heavy investments in R&D that are only profitable because of very high prices in the US, and that these innovations probably wouldn't be available at the lower cost in other other countries without this profit center. That's just a thesis. It's an interesting one, I'd be interested in reading some discussion of it, especially insightful comments backed with data.

coldtea 14y ago

Or that US health research produces far less bang for the buck, because the companies can charge whatever they want, and the suckers (citizens) have to bend over and cough up the money.

belorn 14y ago

It should also be mentioned (since we are talking about statistics here), that 1/3 of the total US medical research spending is from taxes (congress) and has been consistently been so for 20-30 years. That money has no connections with the current health care system, or insurance companies and is just pure tax money sent into research. From those 1/3, about 95% of all core research is supported, and around 80% of all research into medical conditions that are life threatening. Health care system, insurance companies and patents are for everything else... *The 95% and 80% is number from a talk, and for the moment I can't find references. What I could find is statements about majority funding is used on basic research (http://jama.jamanetwork.com/article.aspx?articleid=205216 http://jama.jamanetwork.com/article.aspx?articleid=205216 and http://www.nsf.gov/statistics/seind12/c5/c5s1.htm http://www.nsf.gov/statistics/seind12/c5/c5s1.htm). In the future I will hold off on those number in comments until I got direct sources to use with them.

kingkawn 14y ago
If true these stat provide a compelling point of argument for expanded government research funding and less protection for the private insurance system. Do you have a source for it?
- criley 14y ago
  I'd be interested as well, because if he's trying to label all NIH-bound funds as imperative to this process, I think he's overstating his case. Yes, academic institutions do a lot of low level work that pharma companies build on top of, but you'd be surprised how often potential new molecular entities (truly new drugs) do not originate from government sponsored academic sources. (However, the tools, understanding and/or methodologies that made that new NME possible did likely come from those labs!)
  - belorn 14y ago
    One can read the data in different ways, and I don't think anyone doubt that pharma companies do contribute to the investments into new medical innovations. One interpretation that I listen/read about is that NiH and pharma operate on different levels, and thus sadly, NiH's contribution tend to be forgotten because they aren't the people with that pop out the pills bought in the store, even if the pills would not have existed if it hadn't been for the NiH funded research that made the new innovation possible. Then we add patents and insurance companies into the mix, and some people want to paint a picture how innovation gets created. My comment was thus mostly to inform that the largest single funder to medical research is not some for-profit company like Pfizer, but rather tax supported NiH.

baldfat 14y ago

Only profitable drugs. Pediatric Cancer is not one of them so no new Chemotherapy in the US for over 20 years now and counting. Also manufacturing is stupid also. Only one company makes Oxycodone (Pain Killer) there use to be two companies. Now the price has sky rocked and can be in short supply. So my son suffered for a few days due to not getting all the pills he needed. Great system.