4 ms·

Similar experience here on minimal dose of GLP-1. There is definitely something going on here other than "you are just losing weight and that's really why you

Similar experience here on minimal dose of GLP-1. There is definitely something going on here other than "you are just losing weight and that's really why you are healthier". With my labs at my current weight you can not tell that I am a type 2 diabetic. Previously, when I was at this very same weight in the past - all my labs indicated I was prediabetic.

anon291 2mo ago
A lot of metabolic stuff is due to insulin and insulin sensitivity. This drives pretty much everything. Insulin sensitization is pretty terrible and it gets more important as you age. Unfortunately natural selection doesn't need to fix this as it doesn't cause issues until after reproduction and often until after your grandkids are born. Semaglutide and glp1s resensitize it which is why they have these effects. My opinion
- alyandon 2mo ago
  I strongly suspect that it has had an impact on my insulin sensitivity as well.
aucisson_masque 2mo ago
Could be just because you stopped eating bad food. Things improve dramatically once you limit your intake of industrialized food.
- preg_match 2mo ago
  Not that dramatically. Things like fatty liver take a long time to reverse. It’s not like you stop eating junk food and then suddenly your body is chilling. No, the damage is done and takes a long time to repair. It’s like smoking. You can benefits from quitting smoking within 20 minutes. But to reach the full benefit and reversal, you need 15 years.
  - basilgohar 2mo ago
    There are other significant factors beyond the ones you mentioned, such as inflammation due to processed foods, certain oils, and more that are common in industrialized medicine. Plenty of anecdata of people who stopped eating certain categories of food and certain conditions they had for a long time went away. In my son's case, a severe case of eczema that persisted for years went away in a matter of weeks after we significantly reduced the amount of hydrogenated oil products available to him to eat. Sure enough, when we would visit my mom's place which had it, and he'd indulge, the symptoms came back. Same thing when we would buy it at home and he's splurge, he'd have the same problems recur. Cutting it out of the diet is the only thing that correlated highly with the absence of the condition. This happened even after a move from one state to another. One case, not proof, but definitely repeatable in our circumstances. I have heard a LOT of similar stories. Is it proof? No, but it's an amazingly easy thing to try. It's takes an adjustment, but it intuitively makes sense. Processed food of today is something our ancestors wouldn't even recognize as food. It's just not what our bodies were designed to handle. Some can handle it better than others, but such a processed food and artificial sugar-heavy diet can't be called natural or even healthy.
    - preg_match 2mo ago
      A lot of this largely is not true. People think that paleothic humans ate a lot of meat - they did not. They ate very little meat, we eat the most meat we’ve ever eaten now. And the meat they did eat was lean game meat. It was high in unsaturated fats - like our modern day oils. Not like a steak. A steak is a product of farming. It’s a new invention, <10,000 years. Prior, humans ate almost exclusively nuts, fruits and foliage. Yes oils are “refined”, but humans have been eating unsaturated oils predominantly for almost all of our existence. The proliferation of animal fats is very, very new. Really, it’s past 100 years. Before that meat was rare, it was a delicacy, very expensive for people. Now, high sugar is a different story. But the oil thing is complex, it’s not as a simple as oil bad animal fat good and natural. No, it’s very unnatural.
      - somenameforme 2mo ago
- deleted 2mo ago
  [deleted]
- anovikov 2mo ago
  People's habits usually don't change. They still eat the same plastic crap, just less of it.
- alyandon 2mo ago
  My diet consisted mostly of lean meats like chicken and vegetables.
BobbyJo 2mo ago
Being weight X while gaining weight is a significantly different metabolic state than being weight X while losing weight.
highfrequency 2mo ago
Very cool - to be clear, are both your diet composition and calorie intake similar before vs. after?

anon291 2mo ago

A lot of metabolic stuff is due to insulin and insulin sensitivity. This drives pretty much everything. Insulin sensitization is pretty terrible and it gets more important as you age. Unfortunately natural selection doesn't need to fix this as it doesn't cause issues until after reproduction and often until after your grandkids are born. Semaglutide and glp1s resensitize it which is why they have these effects. My opinion

alyandon 2mo ago
I strongly suspect that it has had an impact on my insulin sensitivity as well.

aucisson_masque 2mo ago

Could be just because you stopped eating bad food. Things improve dramatically once you limit your intake of industrialized food.

preg_match 2mo ago
Not that dramatically. Things like fatty liver take a long time to reverse. It’s not like you stop eating junk food and then suddenly your body is chilling. No, the damage is done and takes a long time to repair. It’s like smoking. You can benefits from quitting smoking within 20 minutes. But to reach the full benefit and reversal, you need 15 years.
- basilgohar 2mo ago
  There are other significant factors beyond the ones you mentioned, such as inflammation due to processed foods, certain oils, and more that are common in industrialized medicine. Plenty of anecdata of people who stopped eating certain categories of food and certain conditions they had for a long time went away. In my son's case, a severe case of eczema that persisted for years went away in a matter of weeks after we significantly reduced the amount of hydrogenated oil products available to him to eat. Sure enough, when we would visit my mom's place which had it, and he'd indulge, the symptoms came back. Same thing when we would buy it at home and he's splurge, he'd have the same problems recur. Cutting it out of the diet is the only thing that correlated highly with the absence of the condition. This happened even after a move from one state to another. One case, not proof, but definitely repeatable in our circumstances. I have heard a LOT of similar stories. Is it proof? No, but it's an amazingly easy thing to try. It's takes an adjustment, but it intuitively makes sense. Processed food of today is something our ancestors wouldn't even recognize as food. It's just not what our bodies were designed to handle. Some can handle it better than others, but such a processed food and artificial sugar-heavy diet can't be called natural or even healthy.
  - preg_match 2mo ago
    A lot of this largely is not true. People think that paleothic humans ate a lot of meat - they did not. They ate very little meat, we eat the most meat we’ve ever eaten now. And the meat they did eat was lean game meat. It was high in unsaturated fats - like our modern day oils. Not like a steak. A steak is a product of farming. It’s a new invention, <10,000 years. Prior, humans ate almost exclusively nuts, fruits and foliage. Yes oils are “refined”, but humans have been eating unsaturated oils predominantly for almost all of our existence. The proliferation of animal fats is very, very new. Really, it’s past 100 years. Before that meat was rare, it was a delicacy, very expensive for people. Now, high sugar is a different story. But the oil thing is complex, it’s not as a simple as oil bad animal fat good and natural. No, it’s very unnatural.
    - somenameforme 2mo ago
deleted 2mo ago
[deleted]
anovikov 2mo ago
People's habits usually don't change. They still eat the same plastic crap, just less of it.
alyandon 2mo ago
My diet consisted mostly of lean meats like chicken and vegetables.

BobbyJo 2mo ago

Being weight X while gaining weight is a significantly different metabolic state than being weight X while losing weight.

highfrequency 2mo ago

Very cool - to be clear, are both your diet composition and calorie intake similar before vs. after?