17 ms·

I'd take them even if they didn't make me lose weight - and I'm the type of person that doesn't like takeing Tylenol unless absolutely necessary. The best way

I'd take them even if they didn't make me lose weight - and I'm the type of person that doesn't like takeing Tylenol unless absolutely necessary. The best way I can describe it: my body and mind are no longer is in starvation mode. I plan, do, act and sleep well.

diggerboy 3mo ago
Did you have to reach a certain dose for such effects?
- chadd 3mo ago
  the minimum dose of monjaro (2.5mg injection once/week) can often be enough
barake 3mo ago
Semaglutide does an incredible job of keeping my autoimmune issues in check. The only side effect I've had is needing to drink more water or else I feel like I've got the flu. Minimal tradeoff IMO
- npunt 3mo ago
  oh say more?
  - cjbgkagh 3mo ago
    This is why I took it, auto immune related ME/CFS. Works great. I still get PEM but outside of that I get to live a normal life.
    - emmelaich 3mo ago
      Interesting! Is it possible that you're just eating less of whatever triggers the autoimmune symptoms?
      - cjbgkagh 3mo ago
        No, if that’s all it was then ME/CFS would be a cake walk and it isn’t. I have such a crazy restrictive diet and have had for a long time that one of my issues was being kicked out of doctor's offices for looking too healthy. The diet is necessary but not sufficient.
        s5300 3mo ago
        [dead]
        jelsisi 3mo ago
        I'm in the same boat! I look very healthy, I'm young and most of my bloodwork is great but I have many autoimmune symptoms. I started on semaglutide 1 week ago and your comment brings me hope.
        cjbgkagh 3mo ago
        I started on an extremely small dose and worked up very slowly because I predicted and did in-fact have hyperactivity to it. I got gastroparisis and the associated huge amount of vomiting, couldn’t eat for the first few weeks. But slowly over the course of 3-6 months I was having few and fewer bad days. I take a bunch of other meds as well but this one is one of the most effective. I also do LDN, Amitryptiline, Modafinil, TUDCA, DIM, low dose of TRT and Ipamorelin/ModGRF. I eat the absolute minimum in sugar, one meal per day, and that is usually a large kale salad. The Modafinil / Amitryptiline is probably the most effective treatment I’ve tried, followed by the semaglutide, then the TRT/hGH peptides.
        Scalestein 3mo ago
        Super interesting - my friend has ME/CFS and/or Fibromyalgia and started GLP-1 but seemed to get only the negative side effects and not much benefit. Using Zepbound specifically. Is the Modafinil used for alertness or a different off label purpose? I'm always interested in potential helpful interventions.
  - nwienert 3mo ago
    I've been posting about this including here for years now. I wrote a long post about it a while ago here and on Reddit. At time no one was talking about it, and actually my Reddit post was buried behind tons of others which was frustrating at the time given I had basically shared a partial cure. Now if you search "reddit eds glp-1" or tirzepatide you'll see tons and tons of long threads of people all saying the same thing - it's the only thing that actually helps. For me it was something of a miracle, I have two overlapping immune issues and it seems to just turn me into a much more normal, functional person. Including fixing my sleep. Never was overweight beyond maybe ~15lbs btw when I started or took it, and the effects are 100% not because of just fasting or weight loss. I had tried keto and OMAD before, and been at healthy weight my whole life. There's a definite auto-immune modulating mechanism and it's so strong it seems better than basically most first-class drugs. Even things like prednisone which are like nuclear weapons don't give me relief like Tirzepatide does. Btw highly recommend Tirzepatide of the three GLP-1 drugs, for me at least it's by far the most effective and least side effects.
- spbaar 3mo ago
  Thirst affects me in a different way too. My throat doesn't feel dry and uncomfortable because before it reaches that point I almost get naseous.
- faangguyindia 3mo ago
  I remember reading the Hazada paradox, where they found these Hadza tribe members who live an active life, walking miles, hunting, and doing all physical labour, have the same maintenance calories as a Western person. So where does the energy burn in a sedentary population come from vs highly active Hadza tribe members? Pontzer’s research showed that while the Hadza were highly active, they actually demonstrated lower baselines of certain markers of metabolic and physiological stress over time compared to Western populations. Don't quote me on this; I am paraphrasing things I remember from.
  - Terr_ 3mo ago
    https://pmc.ncbi.nlm.nih.gov/articles/PMC3405064/ https://pmc.ncbi.nlm.nih.gov/articles/PMC3405064/ > Nonetheless, average daily energy expenditure of traditional Hadza foragers was no different than that of Westerners after controlling for body size. The metabolic cost of walking (kcal kg−1 m−1) and resting (kcal kg−1 s−1) were also similar among Hadza and Western groups. The similarity in metabolic rates across a broad range of cultures challenges current models of obesity suggesting that Western lifestyles lead to decreased energy expenditure. > So where does the energy burn in a sedentary population come from vs highly active Hadza tribe members? P.S.: One theory I've seen is that the extra sedentary-spend is in the immune-system, which may have both beneficial and harmful effects, depending on whether it's doing useful work versus causing problems.
faangguyindia 3mo ago
>my body and mind are no longer is in starvation mode What does it mean? If a drug reduces your desire to eat food, wouldn't it also decrease your desire to eat food beneficial for your body? I think the effect most people want is to stop craving junk food but still eat nutritious food required for muscle growth and health.
- ceejayoz 3mo ago
  What if you could intentionally eat good food? I've heard it widely described as reducing mental noise around food.
  - mycall 3mo ago
    People can get fat by eating too much healthy food.
    - faangguyindia 3mo ago
      true but you'll struggle getting tons of calories out of whole foods. This is why mass gainers are popular, underweight people find it hard to gain weight so they dirty bulking using fast food which is often calorie dense. Eating healthy food alone isn't solution, you need to make your life active as well.
      - theturtletalks 3mo ago
        The glycemic index also comes into play. It essentially measures how much certain foods keeps you full regardless of calories. So healthy food, even if you’re consuming the same calories as junk food, is going to keep you full longer.
        imajoo 3mo ago
        Sorry but isn’t GI about how “sugary” a food is…? I don’t believe it doesn’t measure to do how full you feel. https://www.verywellhealth.com/glycemic-index-vs-load-5214363 https://www.verywellhealth.com/glycemic-index-vs-load-521436...
dmayle 3mo ago
I had the same experience, but not with GLP-1 drugs, but by upping my protein intake to about 0.7g per pound of body weight. Night and day, stopped always being hungry... I've tried Noom before (eating highly filling, low calorie foods, but filling, not satiating), but that only worked while I was tracking (and always forcing myself to keep it up)... Losing weight required work on top of that, but the protein just made my hunger response start working properly again.
- sublinear 3mo ago
  I had a similar experience bringing down my A1C. People talk a lot about meat, but not enough about dairy. My prayers were answered at the altars of feta, greek yogurt, half and half, butter, cottage cheese, etc. They made salads not suck. They opened up a ton of lower carb dessert options. My gut health improved. All of my health improved. I no longer treat these humble foods as optional extras. They perfectly fill the gap in my daily protein needs. They were never unwelcome, just forgotten.
  - nullc 3mo ago
    How'd your LDL?
    - sublinear 3mo ago
      Cholesterol levels are normal. I did mention salads, but fair enough, I forgot to mention how important fiber is. Some people look to these comments for advice. I'm not advocating for a crazy diet. I'm just saying people ignore the basics and assume that healthy food has to be miserable. Small changes add up and make a big impact.
- magicalhippo 3mo ago
  I recall reading a metastudy of EU studies about 10 years ago, where they focused on three different diet classes: calorie counting, low carb, high protein. Calorie counting diets had no restrictions on what they ate, as long as the participants didn't exceed the calorie target. Low carb (Atkins) had no calorie restriction but had to restrict carbs. High protein also didn't have calorie restriction but participants had to ensure at least 20% of the calories in meals were proteins. They found that while all helped people lose weight, only the high-protein made it stick reliably. I used that as basis for my own weight loss and it worked very well for me. As you said it made me full in a different way. YMMV.
taurath 3mo ago
As a counter example, I found myself unable to eat anything at all even with anti nausea meds, and my head utterly in a fog that felt like I was becoming ill.
catigula 3mo ago
This sounds concerning to me.

diggerboy 3mo ago

Did you have to reach a certain dose for such effects?

chadd 3mo ago
the minimum dose of monjaro (2.5mg injection once/week) can often be enough

barake 3mo ago

Semaglutide does an incredible job of keeping my autoimmune issues in check. The only side effect I've had is needing to drink more water or else I feel like I've got the flu. Minimal tradeoff IMO

npunt 3mo ago
oh say more?
- cjbgkagh 3mo ago
  This is why I took it, auto immune related ME/CFS. Works great. I still get PEM but outside of that I get to live a normal life.
  - emmelaich 3mo ago
    Interesting! Is it possible that you're just eating less of whatever triggers the autoimmune symptoms?
    - cjbgkagh 3mo ago
      No, if that’s all it was then ME/CFS would be a cake walk and it isn’t. I have such a crazy restrictive diet and have had for a long time that one of my issues was being kicked out of doctor's offices for looking too healthy. The diet is necessary but not sufficient.
      - s5300 3mo ago
        [dead]
      - jelsisi 3mo ago
        I'm in the same boat! I look very healthy, I'm young and most of my bloodwork is great but I have many autoimmune symptoms. I started on semaglutide 1 week ago and your comment brings me hope.
        cjbgkagh 3mo ago
        I started on an extremely small dose and worked up very slowly because I predicted and did in-fact have hyperactivity to it. I got gastroparisis and the associated huge amount of vomiting, couldn’t eat for the first few weeks. But slowly over the course of 3-6 months I was having few and fewer bad days. I take a bunch of other meds as well but this one is one of the most effective. I also do LDN, Amitryptiline, Modafinil, TUDCA, DIM, low dose of TRT and Ipamorelin/ModGRF. I eat the absolute minimum in sugar, one meal per day, and that is usually a large kale salad. The Modafinil / Amitryptiline is probably the most effective treatment I’ve tried, followed by the semaglutide, then the TRT/hGH peptides.
        Scalestein 3mo ago
        Super interesting - my friend has ME/CFS and/or Fibromyalgia and started GLP-1 but seemed to get only the negative side effects and not much benefit. Using Zepbound specifically. Is the Modafinil used for alertness or a different off label purpose? I'm always interested in potential helpful interventions.
- nwienert 3mo ago
  I've been posting about this including here for years now. I wrote a long post about it a while ago here and on Reddit. At time no one was talking about it, and actually my Reddit post was buried behind tons of others which was frustrating at the time given I had basically shared a partial cure. Now if you search "reddit eds glp-1" or tirzepatide you'll see tons and tons of long threads of people all saying the same thing - it's the only thing that actually helps. For me it was something of a miracle, I have two overlapping immune issues and it seems to just turn me into a much more normal, functional person. Including fixing my sleep. Never was overweight beyond maybe ~15lbs btw when I started or took it, and the effects are 100% not because of just fasting or weight loss. I had tried keto and OMAD before, and been at healthy weight my whole life. There's a definite auto-immune modulating mechanism and it's so strong it seems better than basically most first-class drugs. Even things like prednisone which are like nuclear weapons don't give me relief like Tirzepatide does. Btw highly recommend Tirzepatide of the three GLP-1 drugs, for me at least it's by far the most effective and least side effects.
spbaar 3mo ago
Thirst affects me in a different way too. My throat doesn't feel dry and uncomfortable because before it reaches that point I almost get naseous.
faangguyindia 3mo ago
I remember reading the Hazada paradox, where they found these Hadza tribe members who live an active life, walking miles, hunting, and doing all physical labour, have the same maintenance calories as a Western person. So where does the energy burn in a sedentary population come from vs highly active Hadza tribe members? Pontzer’s research showed that while the Hadza were highly active, they actually demonstrated lower baselines of certain markers of metabolic and physiological stress over time compared to Western populations. Don't quote me on this; I am paraphrasing things I remember from.
- Terr_ 3mo ago
  https://pmc.ncbi.nlm.nih.gov/articles/PMC3405064/ https://pmc.ncbi.nlm.nih.gov/articles/PMC3405064/ > Nonetheless, average daily energy expenditure of traditional Hadza foragers was no different than that of Westerners after controlling for body size. The metabolic cost of walking (kcal kg−1 m−1) and resting (kcal kg−1 s−1) were also similar among Hadza and Western groups. The similarity in metabolic rates across a broad range of cultures challenges current models of obesity suggesting that Western lifestyles lead to decreased energy expenditure. > So where does the energy burn in a sedentary population come from vs highly active Hadza tribe members? P.S.: One theory I've seen is that the extra sedentary-spend is in the immune-system, which may have both beneficial and harmful effects, depending on whether it's doing useful work versus causing problems.

faangguyindia 3mo ago

>my body and mind are no longer is in starvation mode What does it mean? If a drug reduces your desire to eat food, wouldn't it also decrease your desire to eat food beneficial for your body? I think the effect most people want is to stop craving junk food but still eat nutritious food required for muscle growth and health.

ceejayoz 3mo ago
What if you could intentionally eat good food? I've heard it widely described as reducing mental noise around food.
- mycall 3mo ago
  People can get fat by eating too much healthy food.
  - faangguyindia 3mo ago
    true but you'll struggle getting tons of calories out of whole foods. This is why mass gainers are popular, underweight people find it hard to gain weight so they dirty bulking using fast food which is often calorie dense. Eating healthy food alone isn't solution, you need to make your life active as well.
    - theturtletalks 3mo ago
      The glycemic index also comes into play. It essentially measures how much certain foods keeps you full regardless of calories. So healthy food, even if you’re consuming the same calories as junk food, is going to keep you full longer.
      - imajoo 3mo ago
        Sorry but isn’t GI about how “sugary” a food is…? I don’t believe it doesn’t measure to do how full you feel. https://www.verywellhealth.com/glycemic-index-vs-load-5214363 https://www.verywellhealth.com/glycemic-index-vs-load-521436...

dmayle 3mo ago

I had the same experience, but not with GLP-1 drugs, but by upping my protein intake to about 0.7g per pound of body weight. Night and day, stopped always being hungry... I've tried Noom before (eating highly filling, low calorie foods, but filling, not satiating), but that only worked while I was tracking (and always forcing myself to keep it up)... Losing weight required work on top of that, but the protein just made my hunger response start working properly again.

sublinear 3mo ago
I had a similar experience bringing down my A1C. People talk a lot about meat, but not enough about dairy. My prayers were answered at the altars of feta, greek yogurt, half and half, butter, cottage cheese, etc. They made salads not suck. They opened up a ton of lower carb dessert options. My gut health improved. All of my health improved. I no longer treat these humble foods as optional extras. They perfectly fill the gap in my daily protein needs. They were never unwelcome, just forgotten.
- nullc 3mo ago
  How'd your LDL?
  - sublinear 3mo ago
    Cholesterol levels are normal. I did mention salads, but fair enough, I forgot to mention how important fiber is. Some people look to these comments for advice. I'm not advocating for a crazy diet. I'm just saying people ignore the basics and assume that healthy food has to be miserable. Small changes add up and make a big impact.
magicalhippo 3mo ago
I recall reading a metastudy of EU studies about 10 years ago, where they focused on three different diet classes: calorie counting, low carb, high protein. Calorie counting diets had no restrictions on what they ate, as long as the participants didn't exceed the calorie target. Low carb (Atkins) had no calorie restriction but had to restrict carbs. High protein also didn't have calorie restriction but participants had to ensure at least 20% of the calories in meals were proteins. They found that while all helped people lose weight, only the high-protein made it stick reliably. I used that as basis for my own weight loss and it worked very well for me. As you said it made me full in a different way. YMMV.

taurath 3mo ago

As a counter example, I found myself unable to eat anything at all even with anti nausea meds, and my head utterly in a fog that felt like I was becoming ill.

catigula 3mo ago

This sounds concerning to me.