8 ms·
Nuclear receptor 4A1 linked to health effects of coffee: study
https://en.wikipedia.org/wiki/Nuclear_receptor_4A1 https://en.wikipedia.org/wiki/Nuclear_receptor_4A1
- wotsdat 6mo ago[dead]
- RickJWagner 6mo agoI was never a coffee drinker, but I became interested because what was said in Arnold Schwarzenegger‘s newsletter. ( There is a ton of medical research covered in there. ) I didn’t dig in too deeply, but started drinking a morning cup of sugar free double mocha cappuccino, to help my workouts. If I’m fooling myself, don’t tell me. I like the cappuccino.
- rhyperior 6mo agoEpisode #103, @FoundMyFitness on Spotify podcasts. All about coffee’s benefits, including for exercise.
- zingababba 6mo agoNice, maybe it balances out nicotine. People who don't pair caffeine with nicotine simply have no clue what they are missing ;)
- neya 6mo ago> People who don't pair caffeine with nicotine simply have no clue what they are missing ;) We do, and that's called cancer;)
- jonnybgood 6mo agoIs there research that links nicotine to cancer? I’m unable to find anything that would suggest nicotine as cancer causing.
- cf100clunk 6mo agoAre you researching whether you'll get cancer if you are extracting 100% pure nicotine and ingesting it? Who does that?
- steve_adams_86 6mo agoA lot of people consume nicotine. It has been isolated and used in products for a long time. There's no clear link to cancer, but it could impact cardiovascular health (like all stimulants seem to). Some research indicates that nicotine can influence how existing cancer behaves and spreads, so that's worth considering.
- cf100clunk 6mo agoRight, point taken, but I wasn't following how nicotine properties were connected to coffee's health benefits.
- Tagbert 6mo agozingababba started this thread talking about mixing caffeine and nicotine.
- christophilus 6mo agoHe was suggesting— jokingly— that maybe coffee cancels out the deleterious effects of smoking, because indeed coffee + a cigar or pipe is truly an excellent experience.
- steve_adams_86 6mo agoMentat-mode engaged
- coffeebeqn 6mo agoMost nicotine users today? Everyone’s using the pure nicotine pouches like zyn and such. I didn’t really find it enjoyable at all
- gavmor 6mo agoIt's the endothelial dysfunction, oxidative stress, increased arterial stiffness, and accelerated atherosclerosis that turn me off.
- soupspaces 6mo ago[dead]
- sfpotter 6mo ago"Serious delirium!"
- maximinus_thrax 6mo agoI quit smoking a long time ago but if there's one thing I'm missing / craving is a hot cup of coffee with two cigarettes on an empty stomach during cold winter mornings... Fuuuuck.
- technothrasher 6mo ago"While caffeine is the major individual component of coffee, the study suggests that it may not be the primary driver of these health effects." All you haters that give me grief for drinking my daily cup of decaf can shut up now.
- obsidianbases1 6mo agoAre you familiar with the process of extracting the caffeine in decaf? Unfortunately it isn't without potential downsides.
- didgeoridoo 6mo agoSupercritical CO2 extraction is pretty innocuous. Just buy good decaf from a place that doesn’t bathe their beans in toxic waste.
- obsidianbases1 6mo agoGood to know. Any recommendations where to find this?
- rhyperior 6mo agoMany coffee distribution sites (like drink trade dot com) tell you the process. I’m a fan of the Swiss water method.
- risyachka 6mo agoRight? All high quality coffee makers use a proper method so there is absolutely zero downside in decaf. Just make sure to check which method they use (all big ones state it on their website or else)
- throwaway902984 6mo agoThere are multiple methods that James hoffman breaks down in this video iirc, if anyone is curious. https://youtu.be/yYTSdlOdkn0?si=uAo3pipjBA91OV5V https://youtu.be/yYTSdlOdkn0?si=uAo3pipjBA91OV5V
- markus_zhang 6mo agoI wonder whether decaf still contains these chemicals. I drank two cups of decaf every day.
- gleenn 6mo agoTFA mentions that decaf contains these properties as well.
- avidiax 6mo agoNot exactly, the article says that the effects aren't linked to caffeine, not that decaf has been shown to have the positive effects or still contain the necessary chemicals.
- gleenn 6mo ago"This may help explain why both regular and decaffeinated coffee have been associated with similar health benefits in large population studies." --TFA
- markus_zhang 6mo agoOh I read what the parent reply says but completely misses this one. Thank you!
- Tepix 6mo ago[dead]
- soupspaces 6mo ago[dead]
- RobRivera 6mo agoI need more dopamine headlines like this to justify my dopamine addiction to coffee.
- Bridged7756 6mo agoNot everything is dopamine. Maybe nitpicky on my end but it gets tiresome when everyone is just like dopamine this, dopamine that, when no one really understands neurotransmitters.
- pjerem 6mo agoHaha, I viewed a video recently (in French) that said « dopamine is right-wing ». It was ironic but interesting : dopamine is viewed as THE neurotransmitter of motivation while in fact it’s only one part of the mechanism. But it’s the part everyone is bragging about because it supports the idea that you can control your dopamine levels and be responsible of your own motivation. The whole point of the argument was that your serotonin and noradrenaline levels were as much as important if not more, and, fat chance, you cannot buy serotonin or noradrenaline supplements. You have to be in mentally in a good place to get those right and that’s not something you have that much control over. Especially your noradrenaline levels are strongly tied to the quality of your environment and that’s why you should politically fight for a better life environment.
- cout 6mo agoAre you saying that non-Parkinson's patients are taking L-DOPA as a supplement? If so, that's nuts. Also dopamine is a precursor to noradrenaline, and serotonin levels are affected by numerous drugs, the most popular of which are antidepressants. That "supplements" for these neurotransmitters has more to do with how effectively they cross the blood-brain barrier and how they might disrupt the gut, since many chemicals in the brain do double duty through functions in both brain and gut.
- vibrio 6mo ago[dead]
- Bridged7756 6mo agoI love coffee. It's good for you, it smells and tastes so good. It wakes you up, and prevents sleepiness after meals. Its stimulant nature is a plus, but not necessarily the main thing.
- EA-3167 6mo agoI would be very cautious about any conclusions regarding its health benefits or detriments. Nutrition research is notoriously difficult to replicate or show causal links in humans engaging with the real world. Texas A&M also has a coffee research center dedicated to promoting and protecting global coffee trade and consumption so… yeah.
- ejohansson 6mo agoSure, but it's also the best we got.
- JXavierH 6mo agoThat's why I moved to decaf. Love coffee, caffeine doesn't like me.
- campbel 6mo agoI am definitely going to do this as I age, I just don't need the stimulant effects as much anymore. That said, the ritual of getting coffee and sipping on something warm in the morning is really important to starting my day right.
- helterskelter 6mo ago[dead]
- joe_mamba 6mo agoSadly, I can't. I tried all the decaf beans in my area and even some fancy online roastery specialized only in decaf beans, and they all tasted like ass, compared to their caffeinated cousins. So much money wasted trying to find good tasting decaf beans. Not sure what the decaffeination process does, but it definitely does not preserve the taste of the "untouched" beans. Are my tastebuds too sensitive?
- pawelduda 6mo agoSeems to also be relevant for yerba mate which also contains chemical compounds that bind to NR4A1
- deleted 6mo ago[deleted]
- panabee 6mo agoHere are more fascinating facts about caffeine and cancer. Caffeine affects the immune system via at least two opposing mechanisms. Mechanism 1: A2A receptor antagonism (immunostimulatory) Tumors and damaged tissues release adenosine, which engages the A2A receptor on immune cells and signals them to stand down. Caffeine antagonizes (i.e., blocks) this receptor. Mechanism 2: Raising intracellular cAMP (immunosuppressive) Caffeine also inhibits phosphodiesterase, the enzyme that hydrolyzes (i.e., breaks down) cAMP. cAMP accumulates inside immune cells, which acts as a "calm down" signal. Note: both mechanisms are dose-dependent. At dietary caffeine levels, A2A antagonism likely dominates, whereas PDE inhibition is weak and mainly relevant at higher concentrations. However, the net immune effect in the tumor microenvironment remains unproven. --- If you would like to learn more, I can outline a framework for technical folks to ease in and become more informed on cancer. Gaps abound. The more people who understand cancer, the faster we get to cures. Moreover, personalized cancer treatment is the obvious future. Knowledge acquired now may pay off later (but hopefully not needed).
- batch12 6mo agoI'm always up for learning more about everything. Point me in the right direction?
- lazyasciiart 6mo ago
- nate8bit 6mo agoI love coffee, so this is a nice read. Couple years ago I switched to french press, fresh beans (grind on demand) & no milk or sugar - okay, a dash of full cream milk sometimes. Has to be strong - you can't drink weak coffee like that!
- 8bitsrule 6mo agoOn the off-chance that someone wants to read the actual science paper rather than a 'sciencex.com' burp : https://www.mdpi.com/2072-6643/18/6/877 https://www.mdpi.com/2072-6643/18/6/877
- rubzah 6mo agoFor the health benefits, without some of the downsides, I believe it is preferable to drink coffee when you are not tired. This way you don't get a crash later, because there is no adenosine build-up (the 'tiredness' signaling molecule that caffeine blocks). I believe this also helps to prevent addiction, because there is also no up-regulation of adenosine receptors. This works great if you drink coffee for the taste, rather than as a way to stay awake (which works in a pinch but is counter-productive over the long term).
- mekdoonggi 6mo agoI generally always sleep well, but enjoy a nice big cup of coffee in the morning. If I'm really sleep deprived, I switch to black tea. Seems odd because you'd think less caffeine would be worse, but the tea is easier on the stomach and somehow "evens out" the sleep deprivation better.
- lofaszvanitt 6mo agoCoffee is a substance that makes you more susceptible to certain stimuli