11 ms·
MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)
- throwaway12pol 7mo agoUnfortunately, I will probably never be able to try that for my GAD even if they confirm the positive effects due to stigma surrounding psychoactive drugs! Yay!
- amarant 7mo agoNitpick: you will probably never be able to try it legally. There are lots of ways you could try LSD tho.
- whalesalad 7mo agopsilocybin is easy to find (even legally, in certain jurisdictions) or cultivate yourself.
- exhumet 7mo agomhm where i live you can go to a hydro grow store and buy the spores that you definitely SHOULD NOT inject into the aio grow bag conveniently placed nearby lol
- cassepipe 7mo agoSome will sell an already conolized growbox. Much harder to fail than the spores.
- exhumet 7mo agoyeah where i am that is definitely skirting the line haha. i am plenty happy that i can just go to the store and buy the spores and its a very nice gray area that no one is looking really looking at. Sadly we did have a proposal fail on the 2024 elections for legalizing a few forms of psychedelics, but also the interest is there which is nice.
- butlike 7mo agoLSD and psilocybin are very different. Wouldn't think it, but it's true
- Denatonium 7mo agoFinding it's half the fun! Going out walking by a creek/river on a warm, rainy spring day is kind of an antidepressant in its own right. When you find a patch of Ovoids and pick a few, it's just all the better.
- estearum 7mo agoWhy? Stigma from whom? MM120 is seeking FDA approval and there are many more in late stage trials for GAD.
- throwforfeds 7mo agoDo you mean it won't be legalized because of stigma, or you personally wouldn't try them because of stigma? People that think psychedelics are evil are just closed minded people that probably need psychedelics in their life. You probably don't want to pay attention to what they think. If you're genuinely looking for healing there are plenty of people that practice psychedelic assisted therapy around the world that could help you take those first steps. It's underground, but not terribly hard to find with some online searching.
- ddorian43 7mo agoLike, just don't tell anybody. And there are many things you haven't tried, like metabolic ketogenic therapy as an example.
- analog8374 7mo ago"Today a young man on acid realized that all matter is merely energy condensed to a slow vibration, that we are all one consciousness experiencing itself subjectively, there is no such thing as death, life is only a dream, and we are the imagination of ourselves. Here's Tom with the weather." -Bill Hicks
- mrroryflint 7mo agoThanks for reminding me of this. One of the all time greats.
- phishin 7mo agoTool.
- mynameisash 7mo agoIn case others don't know, Tool used this quote in their song Third Eye.
- LgWoodenBadger 7mo agoIt's more than just a quote, it's a sample of Bill Hicks himself speaking it.
- thin_carapace 7mo agotoday an evolved monkey realized that the evolution of intelligence via genetic algorithms doesnt line up that well with the scientific trajectory of existence since the big bang , he then realized that his perception of existence would be exactly equivalent to that of a brain in a jar , his final realization was that all realizations are epheremal regardless as to how convincing or conclusive they may seem
- Ylpertnodi 7mo agoI can trip to that.
- 7mo ago
- Rygian 7mo agoThe "surprising way" is by using a derivate of LSD. I'd argue that the surprise is rather on this: "In clinical trials, a single dose significantly outperformed standard treatments, offering hope to those who have found little relief elsewhere."
- jijijijij 7mo agoCalling it the "pharmaceutical form" is borderline misinformation, considering it's just a common salt of LSD. You can get that outside the pharmacy. It's not like actual LSD is ever made in some dirty improv meth lab. Likewise, nobody expects researchers to buy their drugs on the streets. It's just LSD. This "say no to drugs" drug did the trick.
- goodmythical 7mo agoCall me a luddite, but I'd personally honestly preferring knowing my chemist so that I can be relatively certain there's no 2-ci or whatever bs the kids are cutting with or straight up substituting these days. My understanding is that, today in the US (and other markets so far as I know), it is far easier to know a pharmacist than a genuine LSD chemist, though I am several years out of that particular market. Would be nice to know there's been a resurgence of access to ergot via improvement in Claviceps growth or some nifty novel synthesis we didn't have a few years ago.
- throwforfeds 7mo agoWhile I agree that I'd love to have a guarantee on purity, the way to do that is just to make LSD legal, rather than have some private equity backed pharma company tie up the supply. LSD should be a case like insulin or the polio vaccine, as it offers an immense amount of potential for the planet. Sure, if they want to make money by offering retreats in clinical settings for people too afraid to spend an afternoon with a loved one on 100ug of LSD, by all means. But jumping through hoops to lock up the supply of a truly revolutionary molecule that could improve the lives of millions just feels bad to me. Edit: Also, no one is putting 2c-i on a tab of LSD. The doses are way different (~100ug vs 15mg) and chemists that make LSD tend to be pretty sold on it's potential to help humanity and try to keep the supply as pure as possible. You may be thinking of "tusi" or pink cocaine, which is a drug mixture that tends to have ketamine and mdma mixed, and often has had fentanyl creep into the supply. Someone just decided to name it similar to Shulgin's 2C class of drugs for some reason, which is annoying and dangerous.
- kykat 7mo agoIt seems like every few weeks there's an article on how drugs are amazing hitting the front-page.
- thinkingtoilet 7mo agoWell... drugs are amazing. They're so amazing people will literally die for them.
- kubb 7mo agoWhere do you go when you need to escape but can't actually go anywhere? Inwards. Imagination, media, substances, meditation, solitude.
- butlike 7mo agoTo an extent I feel your position, and it can be true in many contexts. I would say, however, that taking a trip to a far off country, and dropping acid serve two different purposes. While I'm sure there's some overlap, you won't get the entirety of the experience from either one exclusively.
- jml7c5 7mo agoHN has some peculiar medical fixations. It comes in waves. For a while there were a lot of submissions about intermittent fasting. 15 years ago people were excited about polyphasic sleep. 10 years ago it was all about modafinil. Enthusiasm about ketamine for depression was big, but it seems to have finally fizzled out.
- kunley 7mo agoIt is tragically funny to consider linking quietness of mind with LSD. It is everything but quiet
- driggs 7mo agoThe "neuroplasticity" which leads to a relative quietness presumably comes after the psychedelic experience. Interestingly, the paper only lists the following adverse effects: visual perceptual changes, nausea, and headache. Given that the patients in the double-blind study were those who suffer from moderate to severe Generalized Anxiety Disorder, I could imagine some significant anxiety in the 200 µg active group! The paper only reports significant results at the 100 µg and 200 µg dose level, not less, which seems like another strike against psychedelic microdosing. The pharmaceutical industry would love to find a magic psychedelic drug which doesn't result in the psychedelic experience, but it seems like that experience is the key to their mental impact.
- chneu 7mo agoYou're describing what's called a critical period. These are well established and lots of research is going on as to why psychedelics seem to put us into a critical period. Lsd, psylocybin and mdma all seem to do it. Peyote does too. While in the critical period, usually a week to 3 months, it is very important to surround oneself with what they want to focus on.
- kunley 7mo agoLSD experience causes a serious lack of sleep. Is the quoted relative quietness after the experience simply an effect of a sleep deprivation? Why to take drugs to have it, then?
- PowerElectronix 7mo ago"Side effects were mild or moderatr and included hallucinations..." Yeah....
- OutOfHere 7mo agoNo. That is a gross and deliberate mischaracterization in bad faith. Here is the full quote: > Side effects were generally mild or moderate and included hallucinations, visual distortions, nausea, and headache. It's important to note, these were more prevalent using the highest dosage -- which we will not be using since it was found to be no more effective.
- OutOfHere 7mo agoOf course they want to repackage a cheaply synthesized substance at 100-1000x the costs even though the original likely works just as well. That's pharma for you.
- khelavastr 7mo agoThis reflects a longstanding...essentially conspiracy...to suppress attention to 5HT2A-based neural regulation because it sheds such poor light on SSRIs
- butlike 7mo agoI land on "if it helps it helps." But if you catch me in a get-together setting and we share a beer together, I'd say: "on the one hand you have a well-determined profitable path in the SSRIs, and on the other hand you have people giving LSD doses away for free to each other. One sits well, one doesn't. One has to wonder why the people aren't giving away SSRIs for free if they work so well, right?"
- Y_Y 7mo agoWhat are you talking about?
- tim-projects 7mo agoI'd argue that the results might not be from the drugs but from the fact that they were heavily monitored by other humans. It's not the drugs that people with high anxiety need, it's people giving them attention and caring for them. These experiments need a control where they just take the drug and they don't have medical staff around.
- throwaway12pol 7mo agoIsn't that basically the same as them using a placebo? If just care has the same effect, then surely heavily monitoring them while providing a placebo drug should work.
- cassepipe 7mo agoThe problem is you can very obviously tell that you have a placebo because nothing is happening. Some studies mitigate that issue by giving a microdose but then maybe only the microsose is necessary? It seems like a hard problem
- cluckindan 7mo agoSuch studies typically use an active placebo, such as methylphenidate.
- butlike 7mo agoBut that doesn't test if the LSD helps in a non-clinical setting, only that the monitoring and attention helps
- lacunary 7mo ago"In this phase 2b, multicenter, randomized, double-blind, placebo-controlled study of 4 dose levels of MM120 that included 198 adults with generalized anxiety disorder, the primary outcome of a dose-response relationship for change in Hamilton Anxiety Rating Scale score at week 4 was statistically significant."
- IAmBroom 7mo ago
- the-golden-one 7mo agoClickbait
- steve-atx-7600 7mo agoI’d be afraid of a treatment like this where you’re sort of different after one treatment. From experience taking ssris, I took one one that worked so well that I had to stop taking it because it removed stress to the extent that I wouldn’t get to class on time or get my homework done before deadlines. Eventually I found a medicine that worked for me. But, if there’s a “before” vs “after” one shot treatment, you have to hope the new you is the one you want assuming you could be stuck there permanently.
- LazyMans 7mo agoA good point, but if stress was your motivator, it might be better to work to reframe that and gain motivation through something else that isn't stress.
- throwaway12pol 7mo agoWhen you have heavy generalized anxiety, you are usually willing to commit to that if it means there is a significant probability of coming out with an improved condition. I had such terrible panic attacks before my treatment with a bunch of different medication that I seriously considered and searched for electroconvulsive therapy and even help from shady religious institutions.
- steve-atx-7600 7mo agoI might have gotten that desperate myself, but I finally found a great physiatrist that gave a shit and was competent. Simply taking Effexor removed my panic attacks without problematic side effects.
- throwaway12pol 7mo agoYeah, changing psychiatrists also helped me. Unfortunately, I had to change drugs a couple of times and ended up taking multiple ones to end my panic attacks. Those drugs left me with long lasting tremors, even after I've stopped taking them, but the tremors are 10000x better than the panic attacks.
- 7mo ago
- catigula 7mo agoThese psychedelic treatments always have substantial limitations, and this is no different; 1. Low volume cohort i.e. 40 participants per dose group 2. Industry sponsored study i.e. MindMed. 3. Think about it; how do you blind psychedelics? It's pretty obvious you're on one when you take it.
- cluckindan 7mo agoLet me guess: Those limitations are ”unscientific” in this context, but when the article is about the dangers of cannabis, they are suddenly okay?
- catigula 7mo agoThis isn't unscientific per se, it's just low quality science. No conclusions should be drawn. There are known treatments with extremely robust, good science.
- Vachyas 7mo agoI recall an experiment where the control group was given Ritalin, and the participants had presumably tried neither Ritalin or the psychedelic. I thought it was pretty cool, since the control group will still "feel" something and potentially think "oh this is it" but since the effects of stimulants like Ritalin have been more studied, the researchers can easily account for it.
- rdtsc 7mo ago> It's usually treated with medications like Zoloft and Paxil that boost and stabilize the neurotransmitter serotonin, leading to reduced anxiety and enhanced emotional well-being How do figure the boost and stabilize part for a patient? Do they take samples of neurotransmitters in the spinal fluid before and after and looking for neurotransmitter concentrations?
- simulator5g 7mo agoThere's a divide in the marketing language vs the research language on this topic. Marketing says some handwavy statement like "Zoloft stabilizes serotonin levels", but the research on the topic basically says that we assume that's how it works based on what we know about the brain & the drug, but we don't actually have proof of the mechanism.
- rdtsc 7mo agoI always think for some reason that by now with all advancements in technology they'd eventually get to a point where they start measuring these things so going to doctor like that people might hear "your level were out of balance, here are the numbers" and then they get treatment and now, look, another lab result shows we fixed your levels. But it doesn't seems we are quite there yet.
- simulator5g 7mo agoYou can't exactly pull some brain matter out to send to the lab, which makes research very difficult.
- rdtsc 7mo agoOf course not in humans. Though can probably be done experimental with animals. With all the side effects and trade-offs involved with these drugs surely they had to be doing something like it? I was mostly thinking maybe sample the blood or spinal fluid, or use imaging tracing markers to see how the imbalance manifests and then it can be corrected.
- butlike 7mo agoAt the risk of sounding like an imbecile, can I ask why LSD-25 can't be the pharmaceutical form of LSD?
- tug2024 7mo ago[dead]
- simulator5g 7mo agoThis will be like legal weed. Assuming it isn't already, the pharma bean counters will turn it into something awful.
- jMyles 7mo ago...legal weed is awful? Weed is better, cheaper, safer, and more diverse that it has been in my lifetime (and I happily smoked it while it was illegal also). Legal weed has been an enormous success (not that there was ever much doubt that it was going to be).
- AndrewKemendo 7mo agoAgreed I’m not sure what the op is suggesting. I probably smoked brick weed a few times in high school but then didn’t again for ~20 years when I held a clearance. Your local closet grower isn’t giving you a terpene percentage breakdown and guarantee of no laces or a return policy This is actual medicine, not hobby baking or ceramics
- snvzz 7mo agoWhy can we not just get plain LSD? I have never heard a reasonable argument.
- _s_a_m_ 7mo agohow about treating the cause for the anxiety?
- HostingSift 7mo agoThe psilocybin data tells a similar story. One or two sessions outperforming months of conventional meds. The fact that both LSD and psilocybin work on neuroplasticity probably isn't a coincidence. Hope regulators don't drag their feet on this for another decade.
- dyauspitr 7mo agoAs someone that has done mushrooms a dozen or so times, I would never ever take them when I’m anxious or depressed. That’s a sure fire way to have a horrible trip. Maybe these are referring to pretty small doses.
- HostingSift 7mo agoFair point about set and setting, taking a big dose when you're in a bad place is asking for trouble. But the research and most microdosing protocols are talking about way smaller amounts, like 0.15-0.3g every other day. That's well below the 1.5-2g where you actually start tripping. Personally microdosing in that range has helped me a lot with focus and creativity, no trip, no weirdness, just a subtle shift. It's a completely different thing from what people usually imagine when they hear mushrooms.
- dopesoap 7mo agoJust from personal experience I met a bunch of people who did to many psychedelics and became ego maniacs . I also had my first panic attack on acid. Also read about weird therapists taking advantage of people on psychedelics during therapy. I'm a believer in the use of psychedelic therapy but there really needs to be good protocols in place to protect patients who are very vulnerable. I really wish I could go back in time and see the Czech psychedelic clinic it sounded really cool.