4 ms·
I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in
by Aurornis 8mo ago
I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in the 0.1uM range and then taking off in the 1uM range.
I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in this study appear to be in the same range where things start getting really disrupted in cells.
In other words, don’t expect to replicate these results with normal recreational use.
- deleted 8mo ago[deleted]
- mrosett 8mo agoReminds me of this classic: https://xkcd.com/1217/ https://xkcd.com/1217/
- farmdawgnation 8mo agoThere may not be many constants in this life, especially in this day and age, but I do find it humbling that "there is always an xkcd for that" holds true.
- SeanAnderson 8mo ago...is there an XKCD relevant to the fact there's always a relevant XKCD?
- eclecticfrank 8mo agohttps://xkcd.com/244/ https://xkcd.com/244/
- simonh 8mo agoNew studies show that research is a leading cause of cancer in rats.
- jijijijij 8mo agoOn a serious note: Humans are considered an oncogenic species. https://www.nature.com/articles/s41559-018-0558-7 https://www.nature.com/articles/s41559-018-0558-7 (You somehow get the full article via https://www.iflscience.com/humans-may-be-causing-cancer-in-other-species-and-not-in-the-way-you-think-47810 https://www.iflscience.com/humans-may-be-causing-cancer-in-o...)
- jojobas 8mo agoCan't have Alzheimer's if you don't have much of a brain left.
- throwaway27448 8mo agoCan you explain the joke?
- bitwank 8mo ago[flagged]
- lithocarpus 8mo agoIf the doses of cannabis required to cure alzheimers would be high enough doses to destroy the rest of one's brain, it makes this finding not very useful, similar to the idea of curing alzheimers by destroying one's brain/
- Spivak 8mo agoSynthetic cannaboids were also studied as a possible analgesic and at the doses required it caused brain damage. Which is honestly disappointing because a general purpose pain killer that isn't opioid based would be a miracle.
- laserdancepony 8mo agoWe have dozens of pain killers which are not opioid based, what do you mean? From the top of my head NSAIDs can be used, and Metamizole for example is as effective as morphium.
- Muvasa 8mo agoyou got nsaids, metamizole, acetoaminophen, duolexitine. And you got a couple of more that work for neuropathic pain. The biggest problem with nsaids is that they cause bleeding and kidney failure, ulcers hence can cause stomach cancer. Here is a site you can use too see how most pharmaco therapy is lacking. https://pain-calculator.com/calculators/osteoarthritis-pain/ https://pain-calculator.com/calculators/osteoarthritis-pain/
- KennyBlanken 8mo agoI suppose this might be why Willie Nelson is still doing pretty good these days...
- aswegs8 8mo agoYou might have replied to the wrong comment. OP implied it would have no impact
- vercaemert 8mo agoThe joke is that Willie Nelson has used very high concentrations simultaneously frying his brain cells and staving off Alzheimer's.
- wavefunction 8mo agoWillie Nelson is pretty sharp for his age. I compare him to the much younger President of the United States who blathers absolute nonsense constantly despite no known history of cannabis use and a claimed history of abstaining from all substances.
- red-iron-pine 8mo ago> claimed history of abstaining from all substances [rolls eyes] lots of anecdotal evidence suggests donnie t like stimulants, esp. the kind that you can put up your nose.
- butlike 8mo agoIt's stress. I'm convinced of it. Little old lady is smoking cigars at 105 years old because she's stress-free. Willie Nelson is looking sharp for his age because he's low-stress. If it helps reduce your personal stress, perhaps...PERHAPS, it's a good thing.
- __alexs 8mo agoIn vitro studies are not so great for establishing threshold doses surely?
- malfist 8mo agoIn vitro is great for publication though. If I out bleach and Alzheimer's plaques in a petri dish I bet I could publish that sodium hypochlorite treats Alzheimer's
- sixeyes 8mo agoI'm pretty sure 0.1 µmol per liter and such absolutely does happen in recreational use. (Recreational use is toxic, destroys memory, etc.)
- rolph 8mo agoquick back of the envelope: this would require 3 joints of ~ 300 mg cannabis at ~ 30% THC content. the legendary MTF strain regularily trumpets a 25-30% THC content. now if bioavailability is 30% that means you need 9 or 10 joints to get a 1 micro molar total dosage. that dose is distributed across body mass. at this point, i cant say i could conceive of anyone smoking basically an 1/8 ounce of MTA in one day, let alone at one sitting, and doing that for 6 days in a row sounds frightening, not recreational. https://en.wikipedia.org/wiki/Tetrahydrocannabinol https://en.wikipedia.org/wiki/Tetrahydrocannabinol
- aphunx 8mo ago[dead]