6 ms·
A psychedelic medicine performs well against depression
https://archive.ph/rIPvX https://archive.ph/rIPvX
- helterskelter 8mo agoObligatory mirror: https://archive.ph/rIPvX https://archive.ph/rIPvX
- cpncrunch 8mo agoDon't use archive.ph. It's still DDoSing gyrovague.com
- helterskelter 8mo agoWhat's the preferred mirror?
- cpncrunch 8mo agoI havent found any. I just search for non paywalled alternatives now.
- gosub100 8mo agoWhy does it matter
- candiddevmike 8mo agoI believe there have been other studies that prove this for not just the synthetic. Yet we are all supposed to accept the "facts" that psilocybin (and cannabis) are considered schedule 1 illicit substances (high potential for abuse and no currently accepted medical use).
- gosub100 8mo agoIf the risk of getting a minor drug possession charge was the only thing keeping me from curing a serious disease I wouldn't hesitate for a second.
- reverend_gonzo 8mo agoIt is outrageous that both cannabis and psilocybin are scheduled 1 drugs and also completely legal to buy in certain locales.
- Aurornis 8mo ago> and also completely legal to buy in certain locales I'm not trying to be pedantic, but it's important to understand that according to federal law it's not actual legal to possess them regardless of which state you're in. They're still illegal under federal law. A person could technically be prosecuted at the federal level even in a state that doesn't have state-level laws against it, though that's unlikely in practice.
- NickC25 8mo agowhile at the same time, Fentanyl is a schedule II drug.
- tpmoney 8mo agoI'll raise you one better. Cannabis is Schedule I, that means per the DEA there are no known safe medical uses for the drug. But if you synthesize out the primary active ingredient and bundle it in capsule, the DEA happily recognizes that as a mere Schedule III drug, and you get get a prescription for it even in states where cannabis remains illegal at the state level. It goes by the brand name Marinol.
- _alternator_ 8mo agoThe fact that they are using a synthetic version likely means they have constructed a molecule that’s patented or otherwise IP protected. I’m always torn about this, because it means that a cheap, globally available compound (psylocibin) which was what inspired this company to begin with when the founders used it on their son will remain medically inaccessible, possibly at Schedule I in the US, while this startup’s compound may end up being covered by insurance and rake in piles of cash. I get that it takes a lot of money to prove the efficacy of drugs. But there should be a better way to open some of these chemicals up and acknowledge the community that has worked hard, often at great personal and reputational risk, to demonstrate that these well-known drugs offer powerful options to treat a range of psychiatric illnesses.
- reactordev 8mo agoYou just described 150 years of Big Pharma Law. Pharma, sprang up from taking wondrous compounds found in nature and isolated them or refined them into new compounds that they could patent, market, and sell to consumers. Ibuprofen, for example, is crude oil.
- hermanzegerman 8mo agoYet Ibuprofen is so easy to make that only 6 plants make it worldwide and when one goes offline the shortages are felt throughout the world. Might be a bit more difficult than just crude oil
- reactordev 8mo ago6 plants are allowed to make it. Everyone else thought the licensing fee was too high. Unless you are referring to natural botanical plants, in which case, Pine Trees and turpentine is a good alternative found. IANAL but it would still need to find a way around the Ibuprofen compound patent.
- hermanzegerman 8mo agoWhat licensing fee? There aren't any patent protections on Ibuprofen anymore. It's a generic for a very long time. Also last time there was a shortage, one american BASF plant went down and they had trouble for almost a year before they could resume production
- yewenjie 8mo agoDoes anyone know if it is just synthetic psilocybin or a psilocybin-like molecule?
- dzmien 8mo agoFrom what I can tell from searching for "Comp360", it is simply synthetic psilocybin. See https://pmc.ncbi.nlm.nih.gov/articles/PMC10595939/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10595939/
- dekhn 8mo agoEverything I've read from them indicates it's the same chemical, but in a specific formulation. It's described in detail in the patent (one of them: https://patents.google.com/patent/US20200199161A1/en https://patents.google.com/patent/US20200199161A1/en)
- zamalek 8mo agoWhat people get wrong is that you don't just trip balls and get cured. Re-integration therapy is vital for lasting effects. Grabbing some shrooms and digging in is recreation, which is perfectly fine, but don't fool yourself or anyone else by suggesting it's for treatment.
- mewpmewp2 8mo agoI think there's simply so much value in being able to see the same thing in so many different perspectives that you never have considered possible at all in your life before.
- OldSchool 8mo agoThis is particularly true of a deep psychedelic experience "inside" with IV Ketamine. Your own internal processing will still determine how you perceive a perspective change, but specific to this idea in particular, you may for example, within, suddenly find it obvious to think of things as being made of something different than in the outside world reality (and this sort of "change of bases" may reveal some kind of truth not otherwise visible.) You may see something as formed of language instead of molecules and atoms, or vice-versa.
- OldSchool 8mo agoYes. For example, IV Ketamine can yield not only immediate relief in a chemical sense, the treatment itself results in a fully-aware, balls-tripping, metaphor and symbolism-filled, time and space-warping experience in an entirely fictional space. With thoughtful guidance prior-to and after each experience, a series of them can, for example repeat a message until you "get it," or each may deliver a component of a profoundly larger message when they are combined, weeks later. What you do with it all will determine what you get from it.
- topocite 8mo agoI was a depressed teenager a long time ago and I am almost certain mushrooms made things worse. I didn't need mushrooms. I needed therapy, friends, a social life, a sex life, goals, something to look forward to in the real world. All I found on mushrooms at the time were horrible existential loops that just made things more hopeless. I would read about people having these peak wonderful experiences or Mckenna alien experiences and just get more depressed that even the mushrooms didn't help me. It is almost blasphemous in this space to say what actually ended up changing my life were SSRIs. A little prozac fixed something that was just chemically wrong in my head. What seems obvious is there is enormous variability in people's brain chemistry so the tool to fix the problem has to be quite specific for the individual.
- jesse__ 8mo agoAs someone who accidentally discovered the anti-depressive effects of psilocybin in my early 20s, I approve this message!
- cpncrunch 8mo agoNon-paywalled version here: https://qz.com/compass-pathways-psilocybin-fda-clinical-trial https://qz.com/compass-pathways-psilocybin-fda-clinical-tria... Looks like the paper hasn't been published yet, so there isn't really much detail, including blinding effectiveness (which is typically a problem for psychedelics).
- SunshineTheCat 8mo agoI know it will not "solve" every case of depression, however, I really wish people who don't already, would try going outside and/or exercising regularly. Anecdotal I know, but it seems like nearly every person I know who does both are rarely if ever depressed. While the people I've known who do struggle with depression rarely if ever leave home. Again, I know this isn't a catch all for all cases, however, I've seen far too many people turn to meds/substances when lifestyle changes could be all that's required. It's also a couple of things that only have positive side effects as opposed to most of the medicated approaches people take.
- natpalmer1776 8mo agoDo you think perhaps it is possible that you have cause and effect reversed? When suffering from depression lifestyle changes are HARD, especially when dealing with co-morbid mental or physical illness. Conversely a healthy adult of sound mind and body shouldn’t have too much problem deciding that exercise and going outside is beneficial, then just… doing it.
- tsoukase 8mo agoThere are many dimensions and possible pitfalls here. Uncertain mechanism of action, objectionable comparison arms, the high-bar goal of resistant depression that might lead to failure. This seems like a mix situation of a new type of antidepressant (like agomelatin which was of modest effect) and cannabis (which is traded as painkiller but people use it for recreation).