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One must live a very privileged life to mind a 2x a year inconvenience in exchange for a working brain. I wouldn't mind 10x a day injections if it keeps Alzhei

One must live a very privileged life to mind a 2x a year inconvenience in exchange for a working brain. I wouldn't mind 10x a day injections if it keeps Alzheimer's at bay. Actually, I wouldn't mind a continuous IV drip.

bitmasher9 1y ago
I usually consider dialysis to be the point where treatments start to become very limiting. Twice a week, most people feel tied to their dialysis clinic and cannot go far from it.
- vasco 1y ago
  Dialysis specifically requires several hours and a specific location and its debilitating. Going to a random pharmacy to take an injection 2x a week would be much simpler.
  - dmurray 1y ago
    And plenty of people living with diabetes manage to self-medicate with injections multiple times a day.
  - derektank 1y ago
    Being forced to sit in a chair for several hours every few days isn't what makes dialysis so debilitating. It's the loss of kidney function that dialysis doesn't replace, tied with the cardiovascular stress of emptying all the waste from the body at once.
    - vasco 1y ago
      Did anyone say that?
  - Grazester 1y ago
    I have an acquaintance who has lived most of his life without kidneys(40 years). Looking in from the outside, his life seems normal; go to the gym and have a beer or two like anyone would, except for the dialysis trips. I then have a relative into their late 60's that was very laxed about diabetics within recent years.This has lead to kidney issues. They are refusing dialysis because of I guess the stigma attached to it. Now they are experiencing a cognitive decline due to poorly functioning kidneys. I guess when you want to live you would do whatever it takes.
- londons_explore 1y ago
  Why has nobody made a backpack dialysis machine so you can keep going about your day?
  - coldtea 1y ago
    A combination of not quite feasible, not quite usable if created, not quite safe.
  - cma 1y ago
    There are portable ones you can self administer overnight.
  - JackMorgan 1y ago
    If you've ever been to a dialysis center when a patient accidentally pulls out the line you can imagine why. They are thick lines that will rapidly make a huge mess. I guess though a backpack version probably could be more like an always attached glucose device with just a tiny line.
  - jimmydddd 1y ago
    My dad tried out a 24/7 IV for a heart medicine. The pump and a bag with a 1 week supply of the medicine fit in a fanny pack sized bag. It worked well, but he's 90 and pulled out the IV line in the middle of the night. He didn't remember doing it. So we decided to discontinue the meds. But I'm sure it would have been fine for a younger, less confused person. Just a bit inconvenient for showering, etc.
  - hamburglar 1y ago
    There is peritoneal dialysis, which is pretty portable and doesn’t filter the blood (it exchanges peritoneal fluid, which is a lot less invasive). It’s actually quite fascinating how simple the machine is — and in fact, the simplest version of the machine is literally two bags and a couple of valves, completely operated by gravity. Everyone is not eligible for this type of dialysis, however. I don’t remember why. Oh, also, if you do peritoneal dialysis, it’s daily, whereas hemo dialysis is generally two or three times a week.
trhway 1y ago
> wouldn't mind 10x a day injections if it keeps Alzheimer's at bay. Actually, I wouldn't mind a continuous IV drip. There seems to be a much better way: https://publichealth.jhu.edu/2025/small-amounts-of-moderate-to-vigorous-physical-activity-are-associated-with-big-reductions-in-dementia-risk https://publichealth.jhu.edu/2025/small-amounts-of-moderate-... "The researchers found that engaging in as little as 35 minutes of moderate to vigorous physical activity per week, compared to zero minutes per week, was associated with a 41% lower risk of developing dementia over an average four-year follow-up period. Even for frail older adults—those at elevated risk of adverse health outcomes—greater activity was associated with lower dementia risks. The researchers found dementia risk decreased with higher amounts of physical activity. Dementia risks were 60% lower in participants in the 35 to 69.9 minutes of physical activity/week category; 63% lower in the 70 to 139.9 minutes/week category; and 69% lower in the 140 and over minutes/week category."
- lm28469 1y ago
  People keep telling they'd sacrifice everyting for an hypothetical silver bullets while doing nothing in their day to day life to mitigate all these disease. Eat clean, exercise, 8 hours of deep good uninterrupted sleep, &c. 3/4th of people are obese or overweight, the average Joe walks like 4k steps a day, people, at large, don't give a shit about health until they get a terminal diagnosis
  - coldtea 1y ago
    >the average Joe walks like 4k steps a day Which is not that bad. 10k/steps was a made up marketing goal from a speedometer company. The sweet spot is around 7k/steps day, but 4k/steps day is already seeing benefits.
  - foldr 1y ago
    Not everyone can just choose to get 8 hours of uninterrupted sleep! I’d love to.
- jbstack 1y ago
  Apples and oranges. You're talking about prevention, but this is about cure / treatment. Once you have already have Alzheimer's, exercise isn't going to save you.

bitmasher9 1y ago

I usually consider dialysis to be the point where treatments start to become very limiting. Twice a week, most people feel tied to their dialysis clinic and cannot go far from it.

vasco 1y ago
Dialysis specifically requires several hours and a specific location and its debilitating. Going to a random pharmacy to take an injection 2x a week would be much simpler.
- dmurray 1y ago
  And plenty of people living with diabetes manage to self-medicate with injections multiple times a day.
- derektank 1y ago
  Being forced to sit in a chair for several hours every few days isn't what makes dialysis so debilitating. It's the loss of kidney function that dialysis doesn't replace, tied with the cardiovascular stress of emptying all the waste from the body at once.
  - vasco 1y ago
    Did anyone say that?
- Grazester 1y ago
  I have an acquaintance who has lived most of his life without kidneys(40 years). Looking in from the outside, his life seems normal; go to the gym and have a beer or two like anyone would, except for the dialysis trips. I then have a relative into their late 60's that was very laxed about diabetics within recent years.This has lead to kidney issues. They are refusing dialysis because of I guess the stigma attached to it. Now they are experiencing a cognitive decline due to poorly functioning kidneys. I guess when you want to live you would do whatever it takes.
londons_explore 1y ago
Why has nobody made a backpack dialysis machine so you can keep going about your day?
- coldtea 1y ago
  A combination of not quite feasible, not quite usable if created, not quite safe.
- cma 1y ago
  There are portable ones you can self administer overnight.
- JackMorgan 1y ago
  If you've ever been to a dialysis center when a patient accidentally pulls out the line you can imagine why. They are thick lines that will rapidly make a huge mess. I guess though a backpack version probably could be more like an always attached glucose device with just a tiny line.
- jimmydddd 1y ago
  My dad tried out a 24/7 IV for a heart medicine. The pump and a bag with a 1 week supply of the medicine fit in a fanny pack sized bag. It worked well, but he's 90 and pulled out the IV line in the middle of the night. He didn't remember doing it. So we decided to discontinue the meds. But I'm sure it would have been fine for a younger, less confused person. Just a bit inconvenient for showering, etc.
- hamburglar 1y ago
  There is peritoneal dialysis, which is pretty portable and doesn’t filter the blood (it exchanges peritoneal fluid, which is a lot less invasive). It’s actually quite fascinating how simple the machine is — and in fact, the simplest version of the machine is literally two bags and a couple of valves, completely operated by gravity. Everyone is not eligible for this type of dialysis, however. I don’t remember why. Oh, also, if you do peritoneal dialysis, it’s daily, whereas hemo dialysis is generally two or three times a week.

trhway 1y ago

> wouldn't mind 10x a day injections if it keeps Alzheimer's at bay. Actually, I wouldn't mind a continuous IV drip. There seems to be a much better way: https://publichealth.jhu.edu/2025/small-amounts-of-moderate-to-vigorous-physical-activity-are-associated-with-big-reductions-in-dementia-risk https://publichealth.jhu.edu/2025/small-amounts-of-moderate-... "The researchers found that engaging in as little as 35 minutes of moderate to vigorous physical activity per week, compared to zero minutes per week, was associated with a 41% lower risk of developing dementia over an average four-year follow-up period. Even for frail older adults—those at elevated risk of adverse health outcomes—greater activity was associated with lower dementia risks. The researchers found dementia risk decreased with higher amounts of physical activity. Dementia risks were 60% lower in participants in the 35 to 69.9 minutes of physical activity/week category; 63% lower in the 70 to 139.9 minutes/week category; and 69% lower in the 140 and over minutes/week category."

lm28469 1y ago
People keep telling they'd sacrifice everyting for an hypothetical silver bullets while doing nothing in their day to day life to mitigate all these disease. Eat clean, exercise, 8 hours of deep good uninterrupted sleep, &c. 3/4th of people are obese or overweight, the average Joe walks like 4k steps a day, people, at large, don't give a shit about health until they get a terminal diagnosis
- coldtea 1y ago
  >the average Joe walks like 4k steps a day Which is not that bad. 10k/steps was a made up marketing goal from a speedometer company. The sweet spot is around 7k/steps day, but 4k/steps day is already seeing benefits.
- foldr 1y ago
  Not everyone can just choose to get 8 hours of uninterrupted sleep! I’d love to.
jbstack 1y ago
Apples and oranges. You're talking about prevention, but this is about cure / treatment. Once you have already have Alzheimer's, exercise isn't going to save you.