7 ms·
Psilocybin treatment extends cellular lifespan, improves survival of aged mice
- gooodvibes 1y agoNice. Although even if it shortened it, it would still be worth taking.
- lawlessone 1y agoSo it's Spice?
- manmal 1y agoIt’s definitely geriatric.
- SketchySeaBeast 1y agoGeriatric spice was the worst spice girl.
- tombakt 1y agoMelange.
- kubb 1y agoTime to get some shrooms. I could really do with isolated psilocybin capsules though, the taste is terrible.
- throwaway743 1y agoIf you grow them yourself they taste pretty fine. Unsure if not using manure improved the taste though.
- dpc050505 1y agoI find it's not the taste but the texture when they get stuck in my teeth.
- e40 1y agoI wonder if the taste is mainly responsible for people throwing up? Done capsules and never had a problem that particular symptom.
- metadaemon 1y agoI think it's person to person, I've never had any stomach issues at all.
- andoando 1y agoNo I dont think so. Mushroom outer layer is chitin-glucan complex which is really hard for our digestive system to process. Lemon-trek is supposed to help by 1. griding it to a powder, and 2. Putting it in a lemon solution to help do some of that breaking down process
- titanomachy 1y agoI’ve heard this a lot, but I think a good part of the nausea is caused by the same compounds as the psychedelia. LSD seems to cause just as much nausea, and it’s a tiny droplet of liquid absorbed through the mucous membranes.
- andoando 1y agoI haven't experienced stomach issues from LSD, though I haven't always experienced them on shrooms either, so I don't know
- zoklet-enjoyer 1y agoI get motion sick when I hallucinate. I think LSD is the only one that never made my tummy rumble
- basisword 1y agoAs someone who gets motion sick very easily you have put me off mushrooms. Hours of motion sickness while high sounds atrocious.
- dpc050505 1y agoGrind them into powder, mix them to melted semi-sweet chocolate at low heat, pour into ice cube trays and let it harden.
- dkenyser 1y agoLook up lemontek. Drastically shortens the experience, makes it much more consistent and the lemon juice overwhelms the flavor of the mushrooms.
- hombre_fatal 1y agoMan, trying to look up "lemon tek shrooms" was worse than navigating the worst food recipe websites. Alllll that text just to say "grind/soak the shrooms in lemon juice first and it will hit harder and last shorter".
- gooodvibes 1y agoIt's so unnecessary though. You can just eat them as they are, no need to fuss around with grinding and soaking.
- dkenyser 1y agoEh, for me eating them alone can make the experience last upwards of 8-12 hours. Meanwhile using the lemon tek the experience is consistently around 4 hours in length. For me, this is the ideal trip length. I'm very rarely looking to spend my entire day tripping.
- zoklet-enjoyer 1y ago4-aco-dmt is what you want
- tpm 1y agoExactly, pure chemicals are the way to go.
- gametorch 1y agoThere's no way for the average person to know it only contains 4-aco-dmt though. I did 4-aco-dmt multiple times in high school. Luckily, I just tripped and was grateful to be alive on the other side. At least half, if not 15 out of 20 of my friends went completely into psychosis and a good majority of those people had persistent negative symptoms for weeks after.
- tpm 1y agoAgreed. I have bought it legally from a reputable vendor in a country where it was legal at the time (and possibly still is), so I wasn't worried, but ideally some independent authority would do the testing on each batch and post it for everyone to check.
- gametorch 1y agoThat would be ideal. I also considered making my own. But then I thought that rolling your own chemistry could prove to be more fatal than rolling your own cryptography.
- andoando 1y agoYou can buy gelatin capsules on amazon and powder it yourself.
- johnisgood 1y agoI am surprised no one ever mentions psilacetin. You should get it. It is essentially a pill form of psilocybin. It is psilocybin without the shroom matter.
- andoando 1y agoWhere do you get it? In any case, if you put it in a capsule and swallow it, you're not going to be tasting it.
- johnisgood 1y agoIn my case the problem is not really the taste, but shroom matter is difficult to digest, and it is the cause of the nausea, and nausea completely kills the trip for me. I have not tried ginger + honey with ground shroom though. I am not sure where to get psilacetin from, not anymore at least. It was readily available 2 years ago (was cheap as hell, too), but I don't know about today.
- andoando 1y agoHave you tried them powdered? Even just chewing then throughly should help
- johnisgood 1y agoI have not tried them powdered yet, I have no idea if I will do that anytime soon. Ginger + honey + powdered might work.
- foobarian 1y agoWonder if the extra lifespan time is larger than the extra time spent mentally incapacitated due to the effects of the drug.
- itake 1y agothat is how I feel about exercise... spending 10 hours per week in my youth at a gym for 40 years to buy me an extra 10-20 years at the end of my life.
- henry2023 1y ago10-20 extra years + another 15 high quality years in your 60s Finally, exercise is not only gym, hiking, climbing, running, the list is endless
- zafka 1y agoI love the idea of 15 years in my 60s, I guess you are do the calculations in Hexadecimal.
- make3 1y agoyou can do 3 hours and have huge benefits already
- SketchySeaBeast 1y agoYeah, 10 hours a week is totally unneeded.
- dtauzell 1y agoThe main advantage is to make the last 10-20 years better by avoiding injury. Maybe you do t even need 10 hours a week for that, more like 5
- maplant 1y agoExercising makes you feel better. It’s a necessary component of living a good life. Extending your life is irrelevant. However, strength training is necessary to ensure the later parts of your life are worth living
- andoando 1y ago5mg/kg? 1g of shrooms has something like 5-20mg of psilocybin. An equivalent human dose would seem to be 1.3-2.6g a day Edit: Did the math wrong.
- tombakt 1y agoAh yes, a proper morning routine. A bit of coffee, exercise, becoming one with the void…
- samtp 1y agoWell your perception of time would certainly be longer at that dose. Probably feel like you've lived for centuries.
- firtoz 1y agoI can confirm. The wheel turned many times.
- shawabawa3 1y agoYour two statements contradict If 1g of shrooms has 5mg psilocybin, to get a dose of 5mg/kg would be like 75g for an average man (still feels very high but nowhere near 1kg)
- andoando 1y agoSorry did the math completely wrong. And this was a monthly dose, for 75g thats ~2.5g a day
- neom 1y ago"First, we sought to model high-dose used in a clinical study for chronic pain, where patients were administered a psychedelic dose (25 mg) of psilocybin. Using the standard allometric scaling method, a human dose of 25 mg of psilocybin translates to a mouse dose of approximately 5.14 mg/kg."
- andoando 1y ago
- EGreg 1y agoBy how much does it actually extend it? Vegetarians live 10 years longer than meat-eaters. Some studies indicate that vegetarians may live an average of 6 to 10 years longer than meat-eaters, with some studies showing even larger differences for those who switch to a plant-based diet early in life.
- isatty 1y agoCitation?
- bena 1y agoIt sounds familiar, but it's one of those things that's secretly checking something else. Vegetarians are generally more conscious of their health than omnivores. Because you have to realize that omnivores includes the vast majority of people.
- amanaplanacanal 1y agoPeople following any kind of intentional diet live longer than average. Because they are people that care any their health, not because of whichever diet they choose.
- puppycodes 1y agothe only catch is you eventually become a stage 3 guild navigator
- EvanAnderson 1y agoPress release titles really need to say "in vitro" and/or "in mice" when the study was done only in vitro and/or in mice.
- tomhow 1y agoWe've inmiced the title.
- EvanAnderson 1y agoThank you! I wish PR offices would do that themselves. So many health study press releases need the words "in mice" appended to the title.
- tomhow 1y agoIt's got quite a history on HN :) https://hn.algolia.com/?dateRange=all&page=0&prefix=true&query=%22...in%20mice.%22&sort=byDate&type=comment https://hn.algolia.com/?dateRange=all&page=0&prefix=true&que...
- VulpineQuanta 1y ago[dead]
- evanjrowley 1y agoThey feed us poison so we take their 'cures' while they suppress our medicine.
- mekoka 1y agoTwo things. First, please correct me if I'm wrong, but is it possible that the article made a mistake either in the dosages or the substance that was administered? It calls 5mg/kg of psilocybin a low dose. To me, this is an insanely high amount if we're really talking pure psilocybin (not psilocybin mushrooms). Johns Hopkins reported treating people with (high) therapeutic doses of psilocybin (not mushrooms) of between 20mg and 30mg per 70kg. In strictly mushroom weight, that's anything between 3g and 5g of dried cubensis. If the article is correct, what they administer those mice is the equivalent of giving a 70kg human 350mg of psilocybin (as a low dose lol), or about 50g-60g of dried mushrooms to munch on? I hope the article made a mistake, rather than someone from the research team misread the recommended dosage. EDIT: According to my limited search, a 12-weeks old lab rat could weight anything between 0.25-0.5kg. At 5mg-15mg/kg, that's approximately 1.25-2.50mg for low doses of psilocybin and 3.75-7.5mg for high doses. I don't find this as outrageous as originally. It could work if we take into consideration that brain size is probably a more significant factor than body mass. Second. > this study suggests that psilocybin impacts multiple hallmarks of aging by reducing oxidative stress, improving DNA repair responses, and preserving telomere length. Telomeres are the structured ends of a chromosome, protecting it from damage that could lead to the formation of age-related diseases, such as cancer, neurodegeneration or cardiovascular disease. These foundational processes influence human aging and the onset of these chronic diseases. Unless I misunderstand what I'm reading, I wouldn't say that it's really psilocybin (the chemical) that's responsible. It's the taking then subsequent tripping. It's now known that without the trip, no benefit. If my intuition is correct, it could be that LSD along with a few other psychedelics (and associated practices) might affect you in a similar way over the long run.
- Out_of_Characte 1y agoDosing seems correct, they established that psilocin (the metabolite of psilocybin ) increases lifespan. The on hand mouse expert likely understood roughly how much psilocybin could be metabolised safely by the mouse. The mice also had some head jerk indicating that they were under influence and they also established that the mice didn't lose more weight compared to the control group. Some comparisons between animals and humans just aren't compatible with understanding dose and volume. Some smaller animals eat their weight in food, I just wouldn't recommend basing your own dietary fiber intake on that.
- fny 1y agoCan someone comment on why SSRIs wouldnt have a similar effect? The hypothesis seems to be seratonin affects aging. Does it matter where it comes from?
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- gaudystead 1y agoIf anyone has yet to see it, there's a current show called "Common Side Effects" that has a similar vein of thought to this study (a mycologist discovers a mushroom capable of healing illnesses, wounds, and even restoring life to dead creatures, humans included). Highly recommend if you can get past it being animated.
- atombender 1y agoFantastic show. The co-creator, Joseph Bennett, also co-created Scavengers Reign, which is a masterpiece. While more obviously science fiction, it shares some thematic and aesthetic similarities with Common Side Effects.
- mettamage 1y agoYea, that's how I found out about the show Scavengers Reign is one of the best shows I've ever seen. While I really like Common Side Effects, the way Scavengers Reign was done is really hard to beat.
- mettamage 1y ago> Highly recommend if you can get past it being animated. I actually liked it more because it was animated. Trippy worlds are more fun to see animated.
- awanderingmind 1y agoCool study. I really want to believe the results, but the effect on life extension is so large (see figure 2B) that I find it hard to. Maybe there was some uncontrolled confounding factor? It is noted in the 'Methods' section that 'Researchers were not blinded to group allocation [...]', which is unfortunate.