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Biomolecular shifts occur in our 40s and 60s (2024)
- morninglight 1y agoFinally, science has confirmed what our grandparents told us for generations. Ringo Starr even sang the song, "Life Begins at 40".
- jansan 1y agoThere is a very famous German song with the (translated) title "Life begins at 66". So here we have it, 40s and 60s, no science required.
- aswegs8 1y agoThat's quite well-known already. The real question here: how do we stop these shifts from happening?
- JumpCrisscross 1y ago> The real question here: how do we stop these shifts from happening? Or what happens when we stop them? Perpetual adolescence seems mainstream now. But it would be nice to know if some of these changes should be brought up as well as pushed back.
- deleted 1y ago[deleted]
- lm28469 1y agoIsn't perpetual adolescence a lifestyle description, not a biological one?
- ulf-77723 1y agoWhen I look into my biohacker bubble, the answer might be: enough sleep, regular workout routine with HIIT, healthy whole foods, no alcohol, socializing
- ukuina 1y agoAt what age?
- andsoitis 1y agoThese should be lifelong behaviors
- admissionsguy 1y agoand yet none of that makes even a dent
- bboygravity 1y agoIt does. Look up Brian Johnson
- BennyH26 1y agoBryan Johnson. Brian Johnson is the “Liver King”
- 4gotunameagain 1y agoBoth dudes are equally cringe.
- dzhiurgis 1y agoYou should actually watch Bryan's videos, he's pretty funny and down to earth techie. Are his therapies are over the top and lacking a bit of experimental rigor? Probably. Does he look healthy af? Definitely.
- 4gotunameagain 1y agoI actually have. Dude did a "family blood transfusion" with his dad and son. Ew gtfo. And to me he doesn't look healthy af. His skin is good, sure.
- JonChesterfield 1y agoPossibly with a hyperbaric oxygen chamber.
- bigbacaloa 1y ago[dead]
- 4b11b4 1y agostrength training
- nmeofthestate 1y ago>The real question here: how do we stop these shifts from happening? We don't - people inevitably age and die. All you can hope to do is postpone these shifts, and I suspect a large component in the timing is genetic, so there isn't a magical solution that will work for everybody just because it works for the guy posting about the one guaranteed solution for preventing ageing, because it's worked so far for him.
- riskassessment 1y agoIf you throw some data at a clustering algorithm, the clustering algorithm is guaranteed to give you clusters back. So I'm not convinced about the results suggesting a precise pattern of rapid aging.
- petesergeant 1y agoIs it possible that scientists employed at Stanford will have also had this insight, and worked around it?
- deegles 1y agopossible, yes. did they? that's the question
- blackbear_ 1y agoYes they did, and published it all. Sometimes I can't believe how low discussions on HN can fall. Did really nobody in this thread bother to check this? Are we fine disparaging research solely based on the fact that they used a method that gives bad results with bad inputs (which doesn't?) and their incentives could be misaligned (whose aren't?)? If there are well justified concerns about the method or data then by all means let's talk about it, but please let's all try to keep low effort anti intellectual conspiracy theories away from here.
- riskassessment 1y agoI read the paper before I made my original comment. They fit a clustering algorithm and then hand waved at intepreting the clusters. 'Omics papers get away with a lot of hand waving. Yeah they did some peak detection and found peaks, but you are going to find peaks in a random walk. They didn't test the theory that rapid aging occurs at those two specific time points in an independent hold out set. Most importantly even if these peaks exist this paper does not prove they are biological. They could correspond to common socially driven changes in behavior
- bsdz 1y agoProbably the same study from this slightly older thread https://news.ycombinator.com/item?id=41247085 https://news.ycombinator.com/item?id=41247085
- degamad 1y agoYep, both eventually link to https://www.nature.com/articles/s43587-024-00692-2 https://www.nature.com/articles/s43587-024-00692-2 "Nonlinear dynamics of multi-omics profiles during human aging"
- bix6 1y ago34, 60, and 78 according to this other one: https://med.stanford.edu/news/all-news/2019/12/stanford-scientists-reliably-predict-peoples-age-by-measuring-pr.html https://med.stanford.edu/news/all-news/2019/12/stanford-scie...
- nine_k 1y agoThe study in the post agrees on 60, but mentions 44 as the (average? median?) age of another intense change.
- deleted 1y ago[deleted]
- raverbashing 1y agoSounds like I still haven't gone through the molecular shifts that would have made me forget when this was first posted.
- nakedneuron 1y agoTruth is many people also stop moving (exercising) significantly in their forties (reason being probably sitting lifestyle promotes posture and fascia degradation which makes moving less and less enjoyable). I'd posit that another significant decline in moving occurs in the sixties when many go in rent. Not sure if the biological clock is cause of abrupt changes or rather our scheduled lives. So, no significant changes from the sixties on? Then what's the genetic function of those programmations? People who reach old age (100+) are mostly also comparatively healthy.
- nurettin 1y ago> people also stop moving (exercising) significantly in their forties Also likely that people who never experienced the negative outcomes of a sedentary or unhealthy life style start doing so due to the biomolecular changes. Drinking more likely to hurt your liver, soda more likely to cause diabetes, smoking more likely to cause cavities despite having done all that for 20 years without visible problems.
- gspetr 1y ago>20 years without visible problems. Even with the most charitable steelman interpretation of "visible problems", 2 out of 3 things you've listed have strong evidence for being responsible for weight gain, and even smoking has some weaker evidence supporting it.
- agumonkey 1y agoRegular whole body physical activity (not even gym level hard) is such a gem and a free one.
- safety1st 1y agoWithout writing a book about it I'll just say that I think the most important thing is people shouldn't look at this info and conclude that their body's going to fall apart no matter what. I'm in my mid 40s and in the best shape of my life, lots of energy, aches and pains from my late 30s have all disappeared, to get there it took diet and exercise changes that were surprisingly modest. For me it was mostly weights, a little bit of cardio, and cutting back on my worst episodes of caloric excess. I have friends who didn't do any diet and exercise interventions, and are starting to look like hell and complain about the "inevitable" consequences of aging. And then there are those jacked dudes in their 70s who are hitting the gym 5 times a week, I can only aspire to be as healthy as them at their age. Use it (with proper care and feeding) or lose it.
- ohthehugemanate 1y agoParticularly interesting is that when they split the dataset by sex, the transitions were present and at a similar magnitude in both sexes. We make much in western culture of the (peri-)menopausal change in women. I read this as an indicator that at least significant parts of the transition in this age range for men - acknowledged for a long time now - are just as big as menopause. I don't remember noticing that the last time this study came around, but then again, I am in my mid 40s. :)
- squidbeak 1y ago> I read this as an indicator that at least significant parts of the transition in this age range for men - acknowledged for a long time now - are just as big as menopause Men emerge from it with their fertility intact.
- darkwater 1y agoSorry but your post as strong #notallmen vibes. The article itself mentions that part of those changes might just be explained by lifestyle changes at 40s. I quote: > It's possible some of these changes could be tied to lifestyle or behavioral factors that cluster at these age groups, rather than being driven by biological factors, Snyder said. Changes in women metabolism due to menopause are pretty known and proved, and men don't experience it. I'm a mid-40s male as well.
- Nopoint2 1y agoI still stand by my claim that the most common cause of death is chronic iron poisoning, and living past 100 was a regular occurence in the bronze age. The best explanation again seems that all the modern nutrition is nonsense fed by some double agent to the allies in WW2, (iron, and the toxicity of heavy metals) based supposedly on some secret concentration camp experiments, and nobody is allowed to question it in order to "not let their sacrifice go in vain" or some such bullshit.
- nmeofthestate 1y agoI'm wondering if I'm currently hitting '60' early or '40' late.
- glitchc 1y agoAfter a certain age, it's important not to give a shit about irrelevant things. Otherwise the stress catches up to you.