5 ms·

It's for this reason in the UK paracetamol (as we call acetaminophen) is only ever manufactured to 500mg tablets. I don't know if that is global.

pasc1878 1y ago
You can get 1000mg tablets but only if prescribed by a doctor
- Ylpertnodi 1y ago
  My doc wouldn't prescribe 1000s for me. I took two 600s (severe pain was kept at bay).
masklinn 1y ago
1000mg is readily available around here, and although 500s are splittable you’ll find the odd 200~250 (mostly for children I assume).
dmckeon 1y ago
Tylenol markets a 650mg Extended Release for Arthritis and Joint Pain: https://www.tylenol.com/products/arthritis/tylenol-8hr-arthritis-pain https://www.tylenol.com/products/arthritis/tylenol-8hr-arthr... It is effective for me for general analgesia. Trigger warning for self harm. The real tragedies with acetaminophen are "cry-for-help" situations where someone thinks it is the same as aspirin, and swallows a handful, perhaps washing it down with alcohol. What might have been a suicide hesitation mark becomes an entry on a liver transplant list - if they are lucky. If you have children, make sure they know which one can be deadly, especially before going off to college.
pests 1y ago
I don’t think it is. Many combinations available in the USA.
Waterluvian 1y ago
Do you guys have liquid forms, especially for children where the dosage is, obviously, entirely up to you? One memory I have of visiting our U.S. head office with a bunch of UK people was the “we have to get to Target because they sell Tylenol in ungodly quantities.” And I thought bottles of 200 pills felt ridiculous up here in Canada.
- hgomersall 1y ago
  Yeah, you can get lower doses. It turns out I was wrong and you can get 1g, but my understanding is it's not used in routine healthcare (for obvious reasons). https://bnf.nice.org.uk/drugs/paracetamol/medicinal-forms/#oral-tablet https://bnf.nice.org.uk/drugs/paracetamol/medicinal-forms/#o... I'd be interested to know if I'm wrong though.
  - Waterluvian 1y ago
    It feels like it’s quite simply a sensible approach to normalize as much as possible.
  - Ey7NFZ3P0nzAe 1y ago
    In france the usual dosage most of the time is 1g
Findecanor 1y ago
Here in Sweden, a carton of 10 × 500 mg is the most you can find without a subscription. (Boxes of twice that amount is supposed to exists but I've never seen it) Two years ago, I was prescribed the maximum dosage: 2 × 500 mg every six hours for a couple of months. Because it wears off more quickly than that, I tried to reduce it to one and a half pill more often but that wasn't enough to have any effect. Caffeine is supposed to reinforce the effect, but of course I had to avoid that to sleep. I also got it as intravenous liquid at a time when I couldn't swallow.
- masklinn 1y ago
  > Here in Sweden, a carton of 10 × 500 mg is the most you can find without a subscription. (Boxes of twice that amount is supposed to exists but I've never seen it) That ain't much, I don't think I've seen boxes with that little around here. Normal packaging is 30~40, and you can get larger boxes, all without a script. Are the boxes that small because sweden tends to use an other analgesic as primary culturally e.g. aspirin or ibuprofen and paracetamol is for more exceptional situations? > Caffeine is supposed to reinforce the effect, but of course I had to avoid that to sleep. If the goal was pain relief, you can combine ibuprofen and paracetamol. They can be staggered or taken together (in which case there's less duration coverage but some evidence that the combination works better than either separately).
  - cess11 1y ago
    Ibuprofen, naproxen and acetylsalicylic acid are also common. I prefer acetaminophen due to the main metabolite being a reuptake inhibitor of CB-active transmitters and I don't drink. I take maybe two-four grams per year, so your 40-pill box would last for a decade.
    - deleted 1y ago
      [deleted]
  - Findecanor 1y ago
    > Are the boxes that small because sweden tends to use an other analgesic as primary culturally e.g. aspirin or ibuprofen and paracetamol is for more exceptional situations? No, I'd say paracetamol is the most common. I think there was an increase in teenagers that tried to overdose on it to commit suicide some years ago. You could easily get 1000mg pills before that.

pasc1878 1y ago

You can get 1000mg tablets but only if prescribed by a doctor

Ylpertnodi 1y ago
My doc wouldn't prescribe 1000s for me. I took two 600s (severe pain was kept at bay).

masklinn 1y ago

1000mg is readily available around here, and although 500s are splittable you’ll find the odd 200~250 (mostly for children I assume).

dmckeon 1y ago

Tylenol markets a 650mg Extended Release for Arthritis and Joint Pain: https://www.tylenol.com/products/arthritis/tylenol-8hr-arthritis-pain https://www.tylenol.com/products/arthritis/tylenol-8hr-arthr... It is effective for me for general analgesia. Trigger warning for self harm. The real tragedies with acetaminophen are "cry-for-help" situations where someone thinks it is the same as aspirin, and swallows a handful, perhaps washing it down with alcohol. What might have been a suicide hesitation mark becomes an entry on a liver transplant list - if they are lucky. If you have children, make sure they know which one can be deadly, especially before going off to college.

pests 1y ago

I don’t think it is. Many combinations available in the USA.

Waterluvian 1y ago

Do you guys have liquid forms, especially for children where the dosage is, obviously, entirely up to you? One memory I have of visiting our U.S. head office with a bunch of UK people was the “we have to get to Target because they sell Tylenol in ungodly quantities.” And I thought bottles of 200 pills felt ridiculous up here in Canada.

hgomersall 1y ago
Yeah, you can get lower doses. It turns out I was wrong and you can get 1g, but my understanding is it's not used in routine healthcare (for obvious reasons). https://bnf.nice.org.uk/drugs/paracetamol/medicinal-forms/#oral-tablet https://bnf.nice.org.uk/drugs/paracetamol/medicinal-forms/#o... I'd be interested to know if I'm wrong though.
- Waterluvian 1y ago
  It feels like it’s quite simply a sensible approach to normalize as much as possible.
- Ey7NFZ3P0nzAe 1y ago
  In france the usual dosage most of the time is 1g

Findecanor 1y ago

Here in Sweden, a carton of 10 × 500 mg is the most you can find without a subscription. (Boxes of twice that amount is supposed to exists but I've never seen it) Two years ago, I was prescribed the maximum dosage: 2 × 500 mg every six hours for a couple of months. Because it wears off more quickly than that, I tried to reduce it to one and a half pill more often but that wasn't enough to have any effect. Caffeine is supposed to reinforce the effect, but of course I had to avoid that to sleep. I also got it as intravenous liquid at a time when I couldn't swallow.

masklinn 1y ago
> Here in Sweden, a carton of 10 × 500 mg is the most you can find without a subscription. (Boxes of twice that amount is supposed to exists but I've never seen it) That ain't much, I don't think I've seen boxes with that little around here. Normal packaging is 30~40, and you can get larger boxes, all without a script. Are the boxes that small because sweden tends to use an other analgesic as primary culturally e.g. aspirin or ibuprofen and paracetamol is for more exceptional situations? > Caffeine is supposed to reinforce the effect, but of course I had to avoid that to sleep. If the goal was pain relief, you can combine ibuprofen and paracetamol. They can be staggered or taken together (in which case there's less duration coverage but some evidence that the combination works better than either separately).
- cess11 1y ago
  Ibuprofen, naproxen and acetylsalicylic acid are also common. I prefer acetaminophen due to the main metabolite being a reuptake inhibitor of CB-active transmitters and I don't drink. I take maybe two-four grams per year, so your 40-pill box would last for a decade.
  - deleted 1y ago
    [deleted]
- Findecanor 1y ago
  > Are the boxes that small because sweden tends to use an other analgesic as primary culturally e.g. aspirin or ibuprofen and paracetamol is for more exceptional situations? No, I'd say paracetamol is the most common. I think there was an increase in teenagers that tried to overdose on it to commit suicide some years ago. You could easily get 1000mg pills before that.