4 ms·

Two tablets work great for me for headaches but results do vary. The danger zone for liver damage is roughly 14 tablets taken all at once. (Less if you've been

Two tablets work great for me for headaches but results do vary. The danger zone for liver damage is roughly 14 tablets taken all at once. (Less if you've been drinking.) From what I'm told, acetaminophen overdose is quite an unpleasant way to die.

chistev 1y ago
The maximum single dose of paracetamol is 1000 mg, and four doses (4000 mg) in 24 hours. Any more and it's liver damage.
- deleted 1y ago
  [deleted]
- johnisgood 1y ago
  I will respond here with links, because my comments regarding NAC and silymarin are getting down-voted. https://emedicine.medscape.com/article/820200-treatment https://emedicine.medscape.com/article/820200-treatment - Treatment for liver damage is NAC (N-acetylcysteine) which is available as a supplement. > N-acetylcysteine (NAC) is the mainstay of therapy for acetaminophen toxicity https://www.ncbi.nlm.nih.gov/books/NBK537183/ https://www.ncbi.nlm.nih.gov/books/NBK537183/ Again, NAC is readily available without prescription. Additionally, see https://www.medscape.com/viewarticle/422884 https://www.medscape.com/viewarticle/422884 for Silymarin (which is found in Milk Thistle). That said, do not exceed the maximum dose. Try ibuprofen, diclofenac, or whatever else, but they are not without risks either. For the record, acetaminophen is the only painkiller you can take on an empty stomach without it causing any GI issues.
  - oliwarner 1y ago
    Acetylcysteine isn't magic though. It needs to be administered within 12h and 5% will have a severe anaphylactic-type reaction with risk of respiratory arrest. And the liver can still have been irreparably damaged due to other factors. In the context of this being a miserable way to kill yourself, it's absolutely awful because there is very much a cut off point where you will still be suffering immeasurable pain and no amount of NAC will save you.
    - johnisgood 1y ago
      I did not say it is magic. At any rate, silymarin is actually "magic". It may help you regenerate parts of your liver. See the link I mentioned. Ultimately, what one needs to do is just... not consume high amounts, or too frequently.
Ey7NFZ3P0nzAe 1y ago
It's terrible that you are counting in tablets instead of actual amount of acetaminophen
- hgomersall 1y ago
  It's for this reason in the UK paracetamol (as we call acetaminophen) is only ever manufactured to 500mg tablets. I don't know if that is global.
  - pasc1878 1y ago
    You can get 1000mg tablets but only if prescribed by a doctor
    - Ylpertnodi 1y ago
      My doc wouldn't prescribe 1000s for me. I took two 600s (severe pain was kept at bay).
  - masklinn 1y ago
    1000mg is readily available around here, and although 500s are splittable you’ll find the odd 200~250 (mostly for children I assume).
  - dmckeon 1y ago
    Tylenol markets a 650mg Extended Release for Arthritis and Joint Pain: https://www.tylenol.com/products/arthritis/tylenol-8hr-arthritis-pain https://www.tylenol.com/products/arthritis/tylenol-8hr-arthr... It is effective for me for general analgesia. Trigger warning for self harm. The real tragedies with acetaminophen are "cry-for-help" situations where someone thinks it is the same as aspirin, and swallows a handful, perhaps washing it down with alcohol. What might have been a suicide hesitation mark becomes an entry on a liver transplant list - if they are lucky. If you have children, make sure they know which one can be deadly, especially before going off to college.
  - pests 1y ago
    I don’t think it is. Many combinations available in the USA.
dogtorwoof 1y ago
You die from liver failure. Which is a horrible way to die. You’re bleeding and clotting at the same time. Your abdomen swells with fluid. Then your legs and your whole body. Your skin turns yellow and you’re itching constantly. You become increasingly confused and violent. Infections start brewing in that pool of fluid in your abdomen.
- andai 1y ago
  I am going to cancel my internet subscription...
  - Waterluvian 1y ago
    You should sign up for Nautilus. Monthly compact discs mailed to your door containing 650MB of assorted interactive multimedia. It was the original broadband (with very large packet size.) (You might need a Time Machine first)
- deleted 1y ago
  [deleted]

chistev 1y ago

The maximum single dose of paracetamol is 1000 mg, and four doses (4000 mg) in 24 hours. Any more and it's liver damage.

deleted 1y ago
[deleted]
johnisgood 1y ago
I will respond here with links, because my comments regarding NAC and silymarin are getting down-voted. https://emedicine.medscape.com/article/820200-treatment https://emedicine.medscape.com/article/820200-treatment - Treatment for liver damage is NAC (N-acetylcysteine) which is available as a supplement. > N-acetylcysteine (NAC) is the mainstay of therapy for acetaminophen toxicity https://www.ncbi.nlm.nih.gov/books/NBK537183/ https://www.ncbi.nlm.nih.gov/books/NBK537183/ Again, NAC is readily available without prescription. Additionally, see https://www.medscape.com/viewarticle/422884 https://www.medscape.com/viewarticle/422884 for Silymarin (which is found in Milk Thistle). That said, do not exceed the maximum dose. Try ibuprofen, diclofenac, or whatever else, but they are not without risks either. For the record, acetaminophen is the only painkiller you can take on an empty stomach without it causing any GI issues.
- oliwarner 1y ago
  Acetylcysteine isn't magic though. It needs to be administered within 12h and 5% will have a severe anaphylactic-type reaction with risk of respiratory arrest. And the liver can still have been irreparably damaged due to other factors. In the context of this being a miserable way to kill yourself, it's absolutely awful because there is very much a cut off point where you will still be suffering immeasurable pain and no amount of NAC will save you.
  - johnisgood 1y ago
    I did not say it is magic. At any rate, silymarin is actually "magic". It may help you regenerate parts of your liver. See the link I mentioned. Ultimately, what one needs to do is just... not consume high amounts, or too frequently.

Ey7NFZ3P0nzAe 1y ago

It's terrible that you are counting in tablets instead of actual amount of acetaminophen

hgomersall 1y ago
It's for this reason in the UK paracetamol (as we call acetaminophen) is only ever manufactured to 500mg tablets. I don't know if that is global.
- pasc1878 1y ago
  You can get 1000mg tablets but only if prescribed by a doctor
  - Ylpertnodi 1y ago
    My doc wouldn't prescribe 1000s for me. I took two 600s (severe pain was kept at bay).
- masklinn 1y ago
  1000mg is readily available around here, and although 500s are splittable you’ll find the odd 200~250 (mostly for children I assume).
- dmckeon 1y ago
  Tylenol markets a 650mg Extended Release for Arthritis and Joint Pain: https://www.tylenol.com/products/arthritis/tylenol-8hr-arthritis-pain https://www.tylenol.com/products/arthritis/tylenol-8hr-arthr... It is effective for me for general analgesia. Trigger warning for self harm. The real tragedies with acetaminophen are "cry-for-help" situations where someone thinks it is the same as aspirin, and swallows a handful, perhaps washing it down with alcohol. What might have been a suicide hesitation mark becomes an entry on a liver transplant list - if they are lucky. If you have children, make sure they know which one can be deadly, especially before going off to college.
- pests 1y ago
  I don’t think it is. Many combinations available in the USA.

dogtorwoof 1y ago

You die from liver failure. Which is a horrible way to die. You’re bleeding and clotting at the same time. Your abdomen swells with fluid. Then your legs and your whole body. Your skin turns yellow and you’re itching constantly. You become increasingly confused and violent. Infections start brewing in that pool of fluid in your abdomen.

andai 1y ago
I am going to cancel my internet subscription...
- Waterluvian 1y ago
  You should sign up for Nautilus. Monthly compact discs mailed to your door containing 650MB of assorted interactive multimedia. It was the original broadband (with very large packet size.) (You might need a Time Machine first)
deleted 1y ago
[deleted]