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The end of compounded GLP-1 drugs leaves many patients in a ‘lose-lose’ position
- pogue 1y agoAnyone have the full article? It's paywalled with no easy bypass.
- Scoundreller 1y agodrop the URL in here: https://search.google.com/test/rich-results https://search.google.com/test/rich-results Click "View Tested Page" and you'll have the raw HTML at the right to copy into an html file and open (or drop the text heavy parts into an AI to remove the formatting). If you selected the Desktop view, open the image in a new tab.
- pogue 1y agoInteresting! There is a link to access that in the Bypass Paywalls Clean extension, but I wasn't sure what that was for. Can you suggest a prompt that would quickly strip all the HTML formatting from a file? There's a lot of broken characters for quotation marks and etc, but I was able to read it. Thanks!
- Scoundreller 1y agoI've tried prompting once, but to be honest, just saving the .html and opening it got the full thing in my browser, so no prompt really needed. Prompts always worked... just was always worried about hallucinations, even when I said not to do those.
- albumen 1y agohttps://archive.ph/VFJ9b https://archive.ph/VFJ9b
- deleted 1y ago[deleted]
- CuriouslyC 1y agoI suspect medical tourism is going to get a big boost from this. You can travel to someplace like Thailand or Taiwan and bring back a 90 day supply, and the savings covers your airfare with some leftovers. If you were going to take a vacation anyhow, it's a win-win.
- HDThoreaun 1y agoYou can order all this stuff on the internet. There are now three extremely popular medical drugs that are illegal or out of reach due to price here. Steroids, abortions, and GLP-1s are more than enough to set up clear net sites that deliver these drugs from Europe or China.
- anovikov 1y ago$350 a month is already almost as much as we pay in EU. It won't get any cheaper than that. Compounded GLP-1 drugs were an intellectual property theft - and not against some evil megacorporation, but impacting a company that actually already saved millions of lives and has capacity to improve lives of billions of people so much more. It could have been probably justified for a short while because of shortages (a logic of "as long as you are unable to satisfy our demand, we will copycat your product ourselves" is cynical, but with some moral stretch, acceptable), but not anymore.
- raincom 1y agoIt is $500 a month after the first month, as El Lilly charges $350 during the first month for a starter dosage.
- ChemSpider 1y ago500 US$ = 442 euro. Does that include the higher doses? Than it is actually cheaper than in Europe. 15mg Zepbound is 489 euro in Germany for a month (4 shots).
- raincom 1y ago$499 per month "[f]or the Zepbound 5 mg, 7.5 mg, and 10 mg vial" [1]. So, I don't know how much they charge for 15 mg. [1] https://zepbound.lilly.com/coverage-savings https://zepbound.lilly.com/coverage-savings
- firecall 1y agoSimilar prices in AU$ here in Australia too. So around AU$300 to AU$400 for a months supply, or thereabouts. It varies - just going off my experience. Hopefully the market will correct the pricing situation once the goldrush calms down. Even my local pharmacist ranted about what a rort it is last time I asked LOL
- sneak 1y agoYou wouldn’t download an injection that makes you not fat… I doubt you will find many here who agree with your usage of “theft” here.
- raincom 1y agoBecome a compounded pharmacist yourself: get lyophilized powder of glp-1 drugs, bacteriostatic water, Leur Lock syringe with a needle, gloves and alcohol pads; make your own glp-1 compound in your home.
- Meekro 1y agoI'm concerned about what would happen if everyone started trying to do this. How many would put themselves in the emergency room, or worse?
- raincom 1y agoI see at least three sources of problems. 1. Test it for mass, purity, endotoxins, whether it is the real deal or not; this can be easily mitigated if one joins some testing group to share costs. 2. Calculate the dosage units properly, as it depends on how much bacteriostatic water is mixed with the powder. Here, many peptide calculators help. Some will end up making mistakes here; instead of taking 5 units, one will take 50 units--this leads to ER visits. 3. Hygiene: use gloves and alcohol wipes.
- Meekro 1y agoMost people's understanding of basic math, and ability to precisely follow directions, is terrible. What's to prevent you from ending up with a concentration that's 10x or 100x what you intended?
- raincom 1y agoRisks, there are risks everywhere. Late Philosopher of Science, Larry Laudan wrote a little book--The Book of Risks: Fascinating Facts About the Chances We Take Every Day
- skissane 1y agoI heard a story once about a research chemist who decided to synthesise LSD for his own use, miscalculated and gave himself a massive overdose-it didn’t kill him, but it rendered him non compos mentis for an extended period. Even domain experts can make dumb mistakes, especially when you separate them from formalised quality control systems aimed at catching those mistakes before anyone is harmed.
- feverzsj 1y agoWhy would FDA do that? Obesity is the biggest public health disaster in US. They should make it as cheap as ibuprofen.
- TylerE 1y agoBecause it’s under patent. There was a temporary allowance for compounding it due to sustained manufacturer shortages but that is in the process of expiring.
- digianarchist 1y agoWasn’t GLP-1 discovered in 1984?
- TylerE 1y agoNot the newer ones that have lower risks of lifetime digestive issues.
- mac-mc 1y agoAs far as we know.
- raincom 1y agoThe first generation drug Exenatide's patent was filed in 1992, but got approved in 2005. The latest one is Tirzepatide, a dual agonist, approved in 2022. Expect soon for Retaglutide, a triple agnonist, in the market.
- apwell23 1y agohopefully to protect my investment in lily
- wyager 1y agoDo you want them to keep spending money on drug R&D to solve all the other problems that still exist?
- foobarkey 1y agoCompounded: 200 USD month; Lilly/Novo Discounted: 350 USD month Seems alright?
- cubefox 1y agoThe article and, indeed, its title, talk about "The end of compounded GLP-1 drugs".
- psgdev 1y agoMost will simply go to the gray/black market. A 2 year supply of Ozempic (Semaglutide) lyophilized in sterile vials is ~$120USD (300mg of Semaglutide, 2.4mg a week at max dose so 125 weeks) on the black/gray market and that's with at least 2 middlemen making a profit so realistically the cost might be closer to $70USD?. Anyone can pay to get it HPLC tested to confirm the quantity, purity, sterility etc not to mention people (bodybuilders) have been using gray market peptides for 10+years and you never hear any stories about something going wrong (Things go wrong with oil based steroids for bodybuilders commonly not peptides in BAC water). Meanwhile that same ~$120USD 2 year supply of Ozempic is $8400 in Europe, $9600 in Canada and $24000 in the USA.
- pogue 1y agoWhile you might be able to get the purity of the compound itself tested, the user buying it ready for injection or even homebrewing it themselves can still have serious sterility issues, heavy metals contaminates and other nasty leftovers in the batch itself from shady companies that sell these "peptides" and etc. When a low quality lab in China is producing something that normally costs such a high amount there are always corners cut, quality issues and people manufacturing it that are not using the same quality control and standards you would even get from a compounding pharmacy. Author William Llewellyn's talk on how the black market of anabolic steroids evolved over the years explains how things like this are made and what sort of contaminates get into gray/black market injectables (regardless of oil or water based). Anabolic Steroids: an evolving black market (28mins) https://youtu.be/0LL7bL4F9G4 https://youtu.be/0LL7bL4F9G4
- psgdev 1y agoPeople regularly test black/gray market peptides in labs for both heavy metals and sterility (USP 61 or 71 I believe). The production of something like Testosterone/anabolic steroids is completely different has higher risks of contamination than peptides which use recombinant DNA or solid phase peptide synthesis. That video is literally about anabolic steroids not peptides. Not to mention there was 0 testing labs in 2012 that users could send their items to, to get tested while there is many now a days. Back then in 2012 unless you had a friend at a University lab that knew analytical chemistry you were out of luck to get anything tested. You aren't wrong about a lab in China cutting corners, having quality issues and low quality control standards but people don't care if they see 10,000+ people using peptides for decades without a single complaint about infection or real problems. "is producing something that normally costs such a high amount" the cost has very little to do with the chemicals themself, the cost is about recouping R&D costs and having a 90% profit margin.
- cmckn 1y agoI’m regularly shown ads on Instagram for a company called “Willow”, which openly markets itself as a source of GLP-1’s for people who don’t meet the medical criteria. “I just want to lose 15 pounds before my beach vacation!” That type of thing. I’m not that upset to see the compounded GLP-1 market reigned in a bit.
- DidYaWipe 1y agoFYI, it's "lose/lose."
- rekabis 1y agoRadical idea: Have the government step in and say, “if you want to sell your drugs in America, you can only sell them to me.” Then the government hammers that price down as low as it can go, and buys in bulk. A small rider is added to everyone’s federal taxes - a few dollars at most - to pay for it all, and the drugs are provided for free with any prescription. It’s called single-payer healthcare, and most any advanced country uses that method to turn a $2,000/mo drug that the end user would pay either directly or through income-reducing insurance, into a $50/mo drug that is paid indirectly through federal taxes at less than 1/100 the cost. But nooooooo… America can’t do this because “socialism is evil”.
- glp1guide 1y agoThis is certainly a problem, but there just isn't much that many can do about the laws as they are written (and the whole incentives of the pharmaceutical industry as we know it). That said, there is some hope on the horizon, some patent expirations have already happened (i.e. liraglutide which is less effective) and some are coming: https://glp1.guide/content/patent-expirations-for-glp1-receptor-agonists/ https://glp1.guide/content/patent-expirations-for-glp1-recep...