4 ms·
Isn’t this just eating less food is good for everything?
by mentos 2y ago
Isn’t this just eating less food is good for everything?
- api 2y agoDo we know? I think that's the question being asked here. Using these drugs seems to improve a bunch of indicators and we're not sure why. It's really interesting to me that there's some evidence for Metformin -- a diabetes drug that suppresses glucose production and appears to do other things we don't fully understand -- having general health benefits and possible life extending benefits in healthy people. Normally it's just used to treat some forms of diabetes. Feels like we're on the cusp of figuring something out about inflammation, aging, and metabolism.
- breck 2y agoYes. Turns out everyone should have just been eating fats all along.
- fredgrott 2y agohmm, ahem no! veg fats okay, animal fats no so much as if you limit them you tend to live longer due to the decrease in oxidative damage.
- greenavocado 2y agoPolyunsaturated fatty acids (PUFAs), whether from plants or animals, are most susceptible to oxidative damage because they have multiple double bonds that can react with oxygen. Each double bond creates a potential site for oxidation. Societies consuming high amounts of oxidized oils (repeatedly heated cooking oils, whether plant or animal) show increased rates of cardiovascular disease Mediterranean populations consuming fresh, minimally processed olive oil show better cardiovascular outcomes Populations with high fresh fish consumption (like traditional Japanese diets) show better health outcomes despite high PUFA intake, likely due to immediate consumption and minimal oxidation Modern food processing/storage methods increase exposure to oxidized fats Fast food consumption correlates with higher intake of oxidized fats due to repeated oil heating Socioeconomic factors influence exposure - processed foods with oxidized fats are often cheaper and more accessible Oxidation status of fats may be as important as the traditional saturated/unsaturated classification
- david-gpu 2y ago> if you limit them you tend to live longer due to the decrease in oxidative damage Can you elaborate on that? Aren't animal fats, particularly dairy, rather rich in saturated fats? And saturated fats oxidize less easily than unsaturated fats precisely because they lack weak double bonds.
- Etheryte 2y agoThere is no known link between how much you eat and Alzheimers, substance abuse, etc. If it was as simple as eating less makes these issues go away, we would've figured that out a long long time ago.
- dmicah 2y agoThere have previously been associations between caloric intake and Alzheimer Disease or Cognitive Aging, for example: https://jamanetwork.com/journals/jamaneurology/fullarticle/782575 https://jamanetwork.com/journals/jamaneurology/fullarticle/7... https://www.pnas.org/doi/10.1073/pnas.0808587106 https://www.pnas.org/doi/10.1073/pnas.0808587106
- Etheryte 2y agoI think it's a fair bit of a stretch to broadly say that this study shows an association. > Conclusion: Higher intake of calories and fats may be associated with higher risk of [Alzheimer Disease] in individuals carrying the apolipoprotein E ϵ4 allele. > The hazard ratios of [Alzheimer Disease] for the highest quartiles of calorie and fat intake compared with the lowest quartiles in individuals without the apolipoprotein E ϵ4 allele were close to 1 and were not statistically significant. For the general population, there was no correlation. Identifying specific genetic outliers where there may be a connection is still useful, but far from a general result.
- arijo 2y agoAlzheimer's is now being referred as type 3 diabetes for a reason. Human metabolism is sensitive to the type of food you eat. Check https://www.metabolicmind.org/ https://www.metabolicmind.org/ as a starting point and follow the rabbit hole to understand the link between what you eat and mental and metabolic illness. Also, GLP-1 also eliminates muscle - your heart is a muscle.
- phil21 2y agoGLP-1 reduces calorie intake and puts many people on a deficit (typically on purpose). This of course will reduce muscle just like any other calorie deficit anyone runs long term.
- slaymaker1907 2y agoDepends on who you are and if you have an eating disorder.
- didgeoridoo 2y agoEating less food and keeping your body from knowing it seems to be a big part of why it works. On GLP-1 agonists, you don’t get nearly the counterbalancing reduction in energy expenditure you usually see with caloric restriction. Your body keeps happily releasing lipid stores, assuming they will be replenished, but they aren’t. Hunger hormones remain untriggered, cortisol stays low, and insulin keeps shuttling glucose into cells to be burned. If you aren’t metabolically deranged, your body does this anyway. But many people have totally decompensated metabolically due to excess energy intake over time, and essentially cannot recover without some kind of treatment. GLP-1 is just the beginning — future compounds will do a better job maintaining muscle mass, for example. But this is looking like an absolute miracle, and once patent protection ends (especially for oral formulations), we’re going to be living in a very different world health-wise.
- arijo 2y agoAssuming you're going to fix a extremely complex system like the human body by just taking a pill is what some people call the bias of Illusion of Control. https://en.wikipedia.org/wiki/Illusion_of_control https://en.wikipedia.org/wiki/Illusion_of_control
- didgeoridoo 2y agoYou’re going to have to be more specific, because I am sure you are not arguing against the concept of medicine.
- david-gpu 2y agoDoes eating less food reduce addiction to tobacco, alcohol and other substances? Because there is mounting (but not conclusive) evidence that GLP-1 agonists do just that.
- phil21 2y agoSample of only a half dozen people close enough to me to talk intimately about it - but for drinking it’s been absolutely proven in my mind for some people. I have one friend in particular who started a GLP-1 drug solely to assist in drinking less - she certainly does not need to lose any weight. It worked like a light switch for her and turned moderately problematic drinking into easily achieved light social drinking. No impact on appetite since she is on a very low dose. I have had the same experience, even though I took it for weight loss to start with. I do know that drinking can be downright unpleasant for me if I push through the aversion after my first drink and try to go for a few more. I have noticed a strong correlation to drinking and my blood sugar crashing rapidly afterwards while on Tirzepatide while wearing a glucose monitor. A single cold beer on hot day with friends is still quite pleasant. Sitting in a bar for hours on end drinking heavily is simply downright uninteresting now before you get into any unpleasant side effects.
- herval 2y agoAdd me to that sample set, I drink far, far less with it
- akira2501 2y ago> turned moderately problematic drinking into easily achieved light social drinking. Is this based on your survey or her self assessment? > Sitting in a bar for hours on end drinking heavily is simply downright uninteresting Yet it used to be? You don't find this situation suspect?
- phil21 2y ago> Is this based on your survey or her self assessment? Both? Being around her, and her self-assessment. Not sure how else one could interpret such a statement. This is all anecdotal evidence and should be taken as such. > Yet it used to be? You don't find this situation suspect? Yes, it used to be moderately interesting sometimes with the right people. Suspect in what manner? That it removes the desire to get inebriated? Perhaps so, since we do not understand the mechanism at play. What we don't know can certainly hurt us. Overall the desire to drink less seems very similar to the impact it has on appetite and hunger levels. In that way, it is not so surprising to me.
- loeg 2y agoI don't think we know conclusively yet. That probably explains quite a lot of it, yes. It's unclear how that would lead to the substance (ab)use results, though.
- ZYbCRq22HbJ2y7 2y agoNo, there are a number of effects of GLP-1 RAs that are not directly related to their initial research and development associated with insulin response, beta cells, etc or recent research associated with appetite suppression. For instance, there is growing research and speculation around dopamine systems in humans. It might be awhile before the research propagates to the realm of popular science. IMO, it kind of represents how incredibly blind we are to supposedly safe compounds, and how arrogant others are for calling for less regulation. When attention is high, suddenly so much more is revealed.