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> to bypass the difficulties of working with membrane proteins in the laboratory, the team used AlphaFold to predict interactions between proteins > AlphaFold
by sandwichsphinx 2y ago
> to bypass the difficulties of working with membrane proteins in the laboratory, the team used AlphaFold to predict interactions between proteins
> AlphaFold predicted that three sperm proteins work together to form a complex. Two of these proteins were previously known to be important for fertility.
https://www.nature.com/articles/nature18448 https://www.nature.com/articles/nature18448
Here’s the paper linked in the article.
Does anyone have experience using AlphaFold? I don’t have a Nature subscription to see how they specifically accomplished this, but I glanced at the AlphaFold GitHub, and I can’t quite wrap my head around getting it to predict something like this. I’m sure it’s not as simple as prompting ChatGPT with a verbal question.
- timr 2y agoThat's not actually the paper discussed in the article. They didn't even bother to link the paper they're discussing. The URL you've linked to is a summary of two other papers from Cell, which solved crystal structures of 2 of the 3 proteins involved. Edit - here is the paper in question: https://www.cell.com/cell/fulltext/S0092-8674(24)01093-6 https://www.cell.com/cell/fulltext/S0092-8674(24)01093-6
- dekhn 2y agoThe link to the paper is at the bottom of this article. Or more correctly they put the text of a link address at the bottom of the article (it's not actually a link); the DOI address itself resolves to the Cell article.
- colejhudson 2y agoThey use AlphaFold Multimer [0]. Demo here [1]. [0]: https://cosmic-cryoem.org/tools/alphafoldmultimer/ https://cosmic-cryoem.org/tools/alphafoldmultimer/ [1]: https://www.youtube.com/watch?v=iGhdrPo6XQM https://www.youtube.com/watch?v=iGhdrPo6XQM