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Bone tissue reparation using coral and marine sponges
- warmedcookie 2y agoPart of the crew. Part of the ship.
- hinkley 2y agoI lost a tooth after the pandemic. To seat an implant they pack the void with one of several things, including sterilized cadaver bone, then wait for the oocytes to colonize and make new bone. I got a synthetic bone sand. Little bits of it migrated like glass slivers would but otherwise it wasn’t bad and at least I didn’t have dead people in my mouth. Obviously this is a bit of a different scenario given the fairly substantial differences in the shape of the wound, but I wonder how much longer we will need to use naturally occurring materials versus synthesized ones, made in a sterile environment.
- Scoundreller 2y agoI uhhh, don’t think oocyte is the right word. Osteoblast maybe?
- 77pt77 2y agodefinitely not oocyte
- jlund-molfese 2y agoOP probably meant to type osteocyte and it got autocorrected to something else
- shiroiushi 2y agoAutocorrect is one of the biggest misnomers in all of history, I think; in fact, it's downright Orwellian. It should be called "auto-incorrect".
- yieldcrv 2y agogenerative grammar
- TeMPOraL 2y agoRight. It's all fun and games until it decides to "correct" drug names in your doctor's notes.
- WilTimSon 2y agoI highly doubt software that doctors use for patient notes and prescriptions would even have the option to enable autocorrect. If it does, that’s a giant oversight on the devs’ part.
- hinkley 2y agoIf I could find the motherfucker who replaces “its” with “it’s” every goddamned time I mean its, his mother fucking days would be over.
- throwway120385 2y agoWe should also defenestrate whoever corrects the previous word or phrase based on what you just typed in iOS. The amount of times I've meant something very technical or specific to a field that a programmer in silicon valley has never heard of and then had that corrected to something else totally meaningless by the second or third word is an infuriating waste of time.
- hinkley 2y agoTyping on phone, late at night. Always a gamble.
- throwup238 2y agoThis is why I don't eat out.
- hinkley 2y agoI already made the “dead people in my mouth” comment so I can’t exactly fault you for this. But someone else can!
- hinkley 2y agoYes, that was supposed to be “osteocyte” but it’s far too late now.
- tuatoru 2y ago"Reparation"? That means the act of paying back, making amends, compensating a second party for a wrong done them. What happened to "repair" as a noun? "Bone tissue repair".
- ImHereToVote 2y agoOP is Scandinavian.
- tuatoru 2y agoYes, but OP is using a word and phrase taken directly from the introduction to the article. I expect better from Stanford.edu.
- viciousvoxel 2y agoIt's not a major error -- the words are etymological siblings and it's clear what was meant. Repair translates to something resembling "reparation" in most romance languages so it's an easy translation mistake to make.
- hinkley 2y agoI worked recently with a guy who learned all of his big words from books. Very, very old books. It was exhausting. And English is my first language. I felt sorry for my Indian coworkers. Jesus man, stop trying to look smart and just talk like a normal person. The intelligence is in the ideas not the words used to convey them.
- elric 2y ago> Jesus man, stop trying to look smart and just talk like a normal person. What is normal to one person may not be normal to another. Especially when someone learns a language from books without much human interaction.
- deleted 2y ago[deleted]
- entropyie 2y agoI suspected this page was written in MS FrontPage, and a quick peek at the source code seems to confirm it! I love to see old pages still online. Netscape Composer got me through the 90s/00s
- skhr0680 2y agoFrontpage 2002 or 2003 to be exact. I didn't know that it A) lasted that long and B) used that much CSS
- deleted 2y ago[deleted]
- db48x 2y agos/reparation/repair/g
- tpoacher 2y agoshame, the original title alludes to a far juicier article!
- birriel 2y agoFrom a cosmetic point of view, almost everybody exclusively focuses on the skin to counter aging, when they should be at least as concerned with bone density. Lots of people have perfect skin, but they still look old. Why? Bone morphology. The zygomatic bone erodes, and the orbital gaps widen. The mandible degrades and pivots down and backwards (jaw rotation). Issues like resorption are currently very challenging. Skin is comparatively much easier. Also (and besides well-known interventions like collagen, retinoids, HA, and dermarolling), Epidermal and Keratinocyte Growth Factors are already very cheap, and showing much promise.
- Luc 2y agoThis interested me, but I had to look up some of it: Zygomatic bone: cheeck bone, https://en.wikipedia.org/wiki/Zygomatic_bone https://en.wikipedia.org/wiki/Zygomatic_bone Orbital gaps: hollow areas around the eyes Mandible: lower jaw, https://en.wikipedia.org/wiki/Mandible https://en.wikipedia.org/wiki/Mandible Resorption: a process in which a substance is lost by being destroyed and then absorbed by the body. HA: hyaluronic acid
- dustypotato 2y agoThank you. I thought i was dumb
- utensil4778 2y agoFor anyone else wondering: your body is continually pulling calcium from your bones for metabolic processes. Usually it gets replaced when you consume something with calcium in it. It makes sense to have somewhere to store extra nutrients so you can keep functioning for a long time between taking in those specific nutrients again. Your body does this with a lot of your organs. Fat is obviously calorie storage, but muscles can also be resorbed for energy under starvation conditions (or just when they're under used). Your kidneys can resorb water from stored urine, and your intestines pull most water out of what you consume. Most neurotransmitters and hormones get recycled at various rates and turned into new molecules. I'm sure there's more, but that's all I know of offhand.
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- hggh 2y ago(2014) [0] [0] https://web.archive.org/web/20141013021330/https://web.stanford.edu/group/mota/education/Physics%2087N%20Final%20Projects/Group%20Gamma/bone.htm https://web.archive.org/web/20141013021330/https://web.stanf...
- jwilk 2y ago(2005) according to the HTTP headers: Last-Modified: Fri, 09 Dec 2005 22:37:30 GMT
- whizzter 2y agoThese kinds of ideas to use stem-cells with foreign materials seemed in vogue back then, no idea how feasible they are in reality but an improvised similar technique for tracheae was how Paolo Macchiarini first got hyped and then convicted (He went on to try it on humans despite skipping animal trials of the technique). https://en.wikipedia.org/wiki/Paolo_Macchiarini https://en.wikipedia.org/wiki/Paolo_Macchiarini
- hinkley 2y ago> Macchiarini was convicted of unethically performing experimental surgeries, even on relatively healthy patients, resulting in fatalities for seven of the eight patients who received one of his synthetic trachea transplants. Fuuuuck. I think I heard about this guy before he went mad scientist, but not after.
- whizzter 2y agoYeah, the early hopeful news spread widely but the scandal and fallout certainly kept things in the news over here for a long time. There's a Netflix pop-documentary called "Bad Surgeon" with a that does cover the viewpoint of the colleagues that turned whistleblowers (and the persecution they endured before media and prosecutors started looking into it) even if much of the focus is on his many concurrent women (the main one believing she's going to be wed by the pope).
- nonameiguess 2y agoIt's a shame Nature seems to keep these articles locked up forever. I found the first reference, which is a study from 2000, which is still paywalled and I can't read it. I'd be curious to know how state of the art has changed since this. I had a two level lumbar interbody fusion seven years ago, the procedure in which discs are removed and replaced by metal spacers that get seeded with a bone graft. Within about 18 months, you've got one solid bone. They seeded it with my own bone, sawed off of my pelvis, plus some kind of growth-stimulating protein. Beats me whether that was coral-derived or synthetic or what. I didn't think to ask. In any case, it certainly worked. It takes a while, but x-rays today look ridiculous. The bone is enormous, effectively growing around the original screws and rods that held everything in place while the bone was growing. I guess the scaffold matrix in me must have been of the coating variety. As far as I was told, the spacers were just the same titanium alloy as the screws and rods, which for some reason don't set off metal detectors, which makes me wonder why nobody makes knives and guns out of the same material. It'd be nice if they put a date on this page. The other references I could find were from 2011 and 1987.
- failrate 2y agoMy left thumb was reconstructed with coral fragments about 27 years ago. The bone exploded due to the growth of a benign cyst. 6 weeks in a cast to stabilize, then surgery to scoop out the cyst and replace the material. Then 6 more weeks in a cast. When discussing replacement materials, my doctor offered cadaver graft or self transplant (surgically removing bone from my wrist or hip to build a graft). I was deep into Steve Haworth at the time, who was experimenting with implant materials including coral, so I asked about coral. Without missing a beat, the doctor said they could definitely do that. I asked if it was expensive, and he said no. I asked if it had a high rate of rejection, and he said it was comparable to self transplant. Why was it not the first suggestion? Why did he not even mention it in the first place? Sadly, I forgot to ask these questions. Tl;dr I had a coral graft, and it worked great.
- alexandrehtrb 2y agoThat's very interesting! Good to hear it!
- Izikiel43 2y agoSo you have a sea thumb?
- spondylosaurus 2y agoI went to school with a kid who got some scoliosis surgery that involved coral but can't remember exactly how. It seemed to go well though!