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Oh god, I've already had to hear Peter Attia talk about this for years and now newsspam sites are catching on? Spoiler: pound it all you want, everyone still d

Oh god, I've already had to hear Peter Attia talk about this for years and now newsspam sites are catching on? Spoiler: pound it all you want, everyone still dying of chronic illness, diabetes, cancer, heart failure, etc. Eat clean and exercise it's your only chance.

prepend 3y ago
I think Attia’s spiel is that you eat clean, exercise, and take rapamycen. It’s not like those are exclusive options. In his book he also goes into how it would be silly to skip the important pieces like diet and exercise and only get to the med portions.
- adamgordonbell 3y ago
  Indeed, and in fact he called the risk profile of rapamycin as picking up a dime in front of a tricycle. It's low risk but low reward. He's also said if you can't deadhang for 2 minutes or farmers walk 2x your body weight, no longevity drugs are likely yo make more of a difference then getting stronger.
  - slily 3y ago
    I recall him saying he wouldn't recommend people younger than about 40 take mTOR inhibitors too, worth noting for young longevity enthusiasts. As I understand mTOR activation/inhibition is a tradeoff between promoting and inhibiting "growth" and the latter is counterproductive for young people. IIRC high meat/protein diets also activate mTOR, which might partially explain why primarily plant-based diets are associated with longer lifespans. Fasting also suppresses mTOR, so mTOR inhibitors are sometimes promoted as an easier way to achieve (some of) the same benefits more easily. On the other hand fasting elevates cortisol which inhibits testosterone. I don't know if mTOR inhibitors like rapamycin have the same effect, but it's also a health concern.
    - xk_id 3y ago
      Suppressing testosterone has important benefits for longevity. It reverses the atrophy of the thymus gland, therefore it makes the immune system more effective.
  - renewiltord 3y ago
    That's a high target. Farmer's walk 320 lb on 160 lb? Holy shit that's heavy. Longevity drugs don't make a difference till that point? Might as well be useless since I think very few people can 2x BW deadlift. If you lift you can do it but most people don't lift heavy.
    - adamgordonbell 3y ago
      I may have the numbers wrong. Maybe it was body weight? He had v02 max goals as well. The point was the you lose muscle and cardio fitness as you age, and that leads to decreased health span. You need headroom in those as you age and that will help more than anything else.
      - dsp 3y ago
        In “Outlive” Attia said the goal was for men to farmer’s carry their body weight for a minute (half BW per hand).
    - eightysixfour 3y ago
      Yeah, I’m not sure exactly what he is basing that one. A 1.5x farmers walk for 10-20m is exceptionally strong in my book.
  - CPLX 3y ago
    A normal 6' tall 200lb man should be able to farmers walk 400lbs? I don't think so.
  - jjtheblunt 3y ago
    > farmers walk 2x your body weight no way (no weigh) that's right. deadlifting 2x body weight is pretty significant and i've spent a ton of time around pro athletes.
derbOac 3y ago
I basically agree with your general sentiment but I think if society is going to really, actually fight mortality, something drastically different has to happen. I don't think rapamycin is that thing but at some point in the future something — or more likely, some things — outside of healthy living are going to find their way into our medical arsenal.
- vonnik 3y ago
  Yamanaka factor-based genetic and chemical treatments that remind your cells’ age. Already showing results on organs like eyes. They’ll come to the US slower than they come to medical tourism destinations.
  - xk_id 3y ago
    We are nowhere near being able to guarantee safety against teratoma formation after epigenetic reprogramming. If this type of intervention ever becomes practical, it will be in the distant future.
    - red-iron-pine 3y ago
      in other words, we refresh your genes but now that they're new and fresh again they may get cancerous?
FabHK 3y ago
I take it that you're not a fan of his book - could you outline why, or whether there are any better ones? Thanks.
riehwvfbk 3y ago
The whole longevity movement is also mostly driven by fear of death. OK, so you take every drug under the sun in the hope of living another day. In order to what? Be a wage slave for longer? Spend more time on Medicare?
- matheusmoreira 3y ago
  > In order to what? Survive until humans start colonizing space.
- unsupp0rted 3y ago
  Yeah why don’t we blow up the planet today instead of another day of wage slavery or Medicare? The idea is to keep living and stay healthier longer, because living is good and the future is bright.
  - riehwvfbk 3y ago
    That's quite a jump, and it's very telling. The planet would actually be much better off without humans living on it. Why blow it up? Leave it to squirrels and manatees and so on.
    - unsupp0rted 3y ago
      The planet doesn't care one way or the other
- fragmede 3y ago
  That's a depressing viewpoint, since that's true, even if you don't manage to find the fountain of youth. Life has joy and meaning. If you have a purpose, whatever it is, then every singlenday longer you're alive is another day you get to help people, to educate them, to heal them, to ease their suffering, do good for the world, spend time with friends and family; whatever!
  - keybored 3y ago
    It’s interesting how my one and only motivator for these things would be the things you mention. I could imagine discovering a zest for life where I decide to take on such longevity advice. On the other hand in the modern age there are now thousands of subcultures for all kinds of things where the people who practice them must surely treat it at least like a hobby (meaning a serious pursuit). So I wonder: are they doing it as a means to an end because life-is-great? Or has it taken on its own life and it’s now being done for the sake of it? There’s just an overwhelming amount of information and advice out there from all these subcultures.[1] What would I do if I found a burning meaning in life? Maybe adopt an eclectic set of advice and lifestyles from all these subcultures as a means to the end of living longer and better? [1] And I know: eat well, exercise... the basics are not complicated. Intellectually speaking.
nradov 3y ago
Peter Attia doesn't recommend rapamycin for most patients. https://peterattiamd.com/davidsabatini-mattkaeberlein/ https://peterattiamd.com/davidsabatini-mattkaeberlein/
deleted 3y ago
[deleted]

prepend 3y ago

I think Attia’s spiel is that you eat clean, exercise, and take rapamycen. It’s not like those are exclusive options. In his book he also goes into how it would be silly to skip the important pieces like diet and exercise and only get to the med portions.

adamgordonbell 3y ago
Indeed, and in fact he called the risk profile of rapamycin as picking up a dime in front of a tricycle. It's low risk but low reward. He's also said if you can't deadhang for 2 minutes or farmers walk 2x your body weight, no longevity drugs are likely yo make more of a difference then getting stronger.
- slily 3y ago
  I recall him saying he wouldn't recommend people younger than about 40 take mTOR inhibitors too, worth noting for young longevity enthusiasts. As I understand mTOR activation/inhibition is a tradeoff between promoting and inhibiting "growth" and the latter is counterproductive for young people. IIRC high meat/protein diets also activate mTOR, which might partially explain why primarily plant-based diets are associated with longer lifespans. Fasting also suppresses mTOR, so mTOR inhibitors are sometimes promoted as an easier way to achieve (some of) the same benefits more easily. On the other hand fasting elevates cortisol which inhibits testosterone. I don't know if mTOR inhibitors like rapamycin have the same effect, but it's also a health concern.
  - xk_id 3y ago
    Suppressing testosterone has important benefits for longevity. It reverses the atrophy of the thymus gland, therefore it makes the immune system more effective.
- renewiltord 3y ago
  That's a high target. Farmer's walk 320 lb on 160 lb? Holy shit that's heavy. Longevity drugs don't make a difference till that point? Might as well be useless since I think very few people can 2x BW deadlift. If you lift you can do it but most people don't lift heavy.
  - adamgordonbell 3y ago
    I may have the numbers wrong. Maybe it was body weight? He had v02 max goals as well. The point was the you lose muscle and cardio fitness as you age, and that leads to decreased health span. You need headroom in those as you age and that will help more than anything else.
    - dsp 3y ago
      In “Outlive” Attia said the goal was for men to farmer’s carry their body weight for a minute (half BW per hand).
  - eightysixfour 3y ago
    Yeah, I’m not sure exactly what he is basing that one. A 1.5x farmers walk for 10-20m is exceptionally strong in my book.
- CPLX 3y ago
  A normal 6' tall 200lb man should be able to farmers walk 400lbs? I don't think so.
- jjtheblunt 3y ago
  > farmers walk 2x your body weight no way (no weigh) that's right. deadlifting 2x body weight is pretty significant and i've spent a ton of time around pro athletes.

derbOac 3y ago

I basically agree with your general sentiment but I think if society is going to really, actually fight mortality, something drastically different has to happen. I don't think rapamycin is that thing but at some point in the future something — or more likely, some things — outside of healthy living are going to find their way into our medical arsenal.

vonnik 3y ago
Yamanaka factor-based genetic and chemical treatments that remind your cells’ age. Already showing results on organs like eyes. They’ll come to the US slower than they come to medical tourism destinations.
- xk_id 3y ago
  We are nowhere near being able to guarantee safety against teratoma formation after epigenetic reprogramming. If this type of intervention ever becomes practical, it will be in the distant future.
  - red-iron-pine 3y ago
    in other words, we refresh your genes but now that they're new and fresh again they may get cancerous?

FabHK 3y ago

I take it that you're not a fan of his book - could you outline why, or whether there are any better ones? Thanks.

riehwvfbk 3y ago

The whole longevity movement is also mostly driven by fear of death. OK, so you take every drug under the sun in the hope of living another day. In order to what? Be a wage slave for longer? Spend more time on Medicare?

matheusmoreira 3y ago
> In order to what? Survive until humans start colonizing space.
unsupp0rted 3y ago
Yeah why don’t we blow up the planet today instead of another day of wage slavery or Medicare? The idea is to keep living and stay healthier longer, because living is good and the future is bright.
- riehwvfbk 3y ago
  That's quite a jump, and it's very telling. The planet would actually be much better off without humans living on it. Why blow it up? Leave it to squirrels and manatees and so on.
  - unsupp0rted 3y ago
    The planet doesn't care one way or the other
fragmede 3y ago
That's a depressing viewpoint, since that's true, even if you don't manage to find the fountain of youth. Life has joy and meaning. If you have a purpose, whatever it is, then every singlenday longer you're alive is another day you get to help people, to educate them, to heal them, to ease their suffering, do good for the world, spend time with friends and family; whatever!
- keybored 3y ago
  It’s interesting how my one and only motivator for these things would be the things you mention. I could imagine discovering a zest for life where I decide to take on such longevity advice. On the other hand in the modern age there are now thousands of subcultures for all kinds of things where the people who practice them must surely treat it at least like a hobby (meaning a serious pursuit). So I wonder: are they doing it as a means to an end because life-is-great? Or has it taken on its own life and it’s now being done for the sake of it? There’s just an overwhelming amount of information and advice out there from all these subcultures.[1] What would I do if I found a burning meaning in life? Maybe adopt an eclectic set of advice and lifestyles from all these subcultures as a means to the end of living longer and better? [1] And I know: eat well, exercise... the basics are not complicated. Intellectually speaking.

nradov 3y ago

Peter Attia doesn't recommend rapamycin for most patients. https://peterattiamd.com/davidsabatini-mattkaeberlein/ https://peterattiamd.com/davidsabatini-mattkaeberlein/

deleted 3y ago

[deleted]