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Epigenetics is not just DNA, think of it more like the (hidden) state of DNA. Histone modifications and open chromatin and other epigenetic readouts are like e
by pfisherman 3y ago
Epigenetics is not just DNA, think of it more like the (hidden) state of DNA. Histone modifications and open chromatin and other epigenetic readouts are like emissions / indicators of the hidden state.
The relationship is like that between the words in a book and the page that is actively being read. I know that is a hackneyed analogy; but coffee is wearing off :)
- dekhn 3y agoThose are all readable using standard DNA sequencing techniques, so again, it's just state attributes of the DNA. (I've worked in genomics for 30+ years. I'm not just spitballing here).
- pfisherman 3y agoDNA libraries are read out using sequencing techniques. But I doubt anyone would say they are just measuring DNA. It’s kind of like saying a luciferase based assay is just measuring the intensity of light.
- dekhn 3y agoyes, that is the terminology we use.