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but epigenetics is just DNA. it's state information stored directly in the DNA, or in directly attached machinery. from the perspective of learned models, tho
by dekhn 3y ago
but epigenetics is just DNA. it's state information stored directly in the DNA, or in directly attached machinery. from the perspective of learned models, those are just other features.
But realistically, the right source for transcription is the RNA in the cell, not the epigenetics. Nearly all cell type profiling is based on RNA. It's far easier and more reliable to interrogate the transcriptome than to try to gain info from epigenetic states.
- pfisherman 3y agoEpigenetics is not just DNA, think of it more like the (hidden) state of DNA. Histone modifications and open chromatin and other epigenetic readouts are like emissions / indicators of the hidden state. The relationship is like that between the words in a book and the page that is actively being read. I know that is a hackneyed analogy; but coffee is wearing off :)
- dekhn 3y agoThose are all readable using standard DNA sequencing techniques, so again, it's just state attributes of the DNA. (I've worked in genomics for 30+ years. I'm not just spitballing here).
- pfisherman 3y agoDNA libraries are read out using sequencing techniques. But I doubt anyone would say they are just measuring DNA. It’s kind of like saying a luciferase based assay is just measuring the intensity of light.
- dekhn 3y agoyes, that is the terminology we use.