5 ms·

I am very skeptical about these side effect claims. Do you have hard data supporting this or doctor hearsay. Years ago I remember watching Charlie Rose Brain se

I am very skeptical about these side effect claims. Do you have hard data supporting this or doctor hearsay. Years ago I remember watching Charlie Rose Brain series where one of the professors said something like “ we know of two drugs that we are certain are very safe for human beings: alcohol and aspirin.”

voisin 3y ago
> “ we know of two drugs that we are certain are very safe for human beings: alcohol and aspirin.” I am not sure I understand. We know alcohol isn’t safe, let alone very safe, in any quantity. So immediately this seems contradictory?
- ergonaught 3y ago
  That appears to have been the point.
nomel 3y ago
Aspirin's bleeding risk is very well studied. You can find many papers showing between around 30% increase in the brain, and around 60% for the gut.
pinko 3y ago
Anecdata: even a few days of low-dose aspirin causes me terrible GI pain and exacerbates an otherwise 30-year dormant ulcer. I would love to be able to take it, but I can't tolerate it at all.
- throwaway290 3y ago
  What was your dosage? Tried dissolving in water?
- Turing_Machine 3y ago
  Have you tried the "enteric coated" aspirin? The coating is supposed to resist dissolving until the pill is well past your stomach.
_yb2s 3y ago
Those are both drugs with very significant risks
mvkel 3y ago
Alcohol has a bunch of recent studies showing that no amount is good, and as little as two drinks per week yield measurable negative impacts.
- Scoundreller 3y ago
  what if I do all the other things that go along with drinking for health, like speak Italian or French while I drink?
  - robocat 3y ago
    First search hit: They report preventable deaths caused by alcohol is higher in France than anywhere else in Europe. Speaking French doesn't appear to help you. Maybe Italian is better.
    - Scoundreller 3y ago
      meh, I just care about all-cause mortality. I'll accept some preventable death risk if it's outweighed by non-preventable death risk improvement. I think the French hit a good sweet spot between high alcohol consumption and high life expectancy. Quite a male-female disparity though. Maybe Irish do better at 0.2years reduction for an extra 0.4l of alcohol per year https://en.wikipedia.org/wiki/List_of_countries_by_life_expectancy https://en.wikipedia.org/wiki/List_of_countries_by_life_expe... https://en.wikipedia.org/wiki/List_of_countries_by_alcohol_consumption_per_capita https://en.wikipedia.org/wiki/List_of_countries_by_alcohol_c...
    - mk67 3y ago
      Sounds like bs if you look at Russian numbers.

voisin 3y ago

> “ we know of two drugs that we are certain are very safe for human beings: alcohol and aspirin.” I am not sure I understand. We know alcohol isn’t safe, let alone very safe, in any quantity. So immediately this seems contradictory?

ergonaught 3y ago
That appears to have been the point.

nomel 3y ago

Aspirin's bleeding risk is very well studied. You can find many papers showing between around 30% increase in the brain, and around 60% for the gut.

pinko 3y ago

Anecdata: even a few days of low-dose aspirin causes me terrible GI pain and exacerbates an otherwise 30-year dormant ulcer. I would love to be able to take it, but I can't tolerate it at all.

throwaway290 3y ago
What was your dosage? Tried dissolving in water?
Turing_Machine 3y ago
Have you tried the "enteric coated" aspirin? The coating is supposed to resist dissolving until the pill is well past your stomach.

_yb2s 3y ago

Those are both drugs with very significant risks

mvkel 3y ago

Alcohol has a bunch of recent studies showing that no amount is good, and as little as two drinks per week yield measurable negative impacts.

Scoundreller 3y ago
what if I do all the other things that go along with drinking for health, like speak Italian or French while I drink?
- robocat 3y ago
  First search hit: They report preventable deaths caused by alcohol is higher in France than anywhere else in Europe. Speaking French doesn't appear to help you. Maybe Italian is better.
  - Scoundreller 3y ago
    meh, I just care about all-cause mortality. I'll accept some preventable death risk if it's outweighed by non-preventable death risk improvement. I think the French hit a good sweet spot between high alcohol consumption and high life expectancy. Quite a male-female disparity though. Maybe Irish do better at 0.2years reduction for an extra 0.4l of alcohol per year https://en.wikipedia.org/wiki/List_of_countries_by_life_expectancy https://en.wikipedia.org/wiki/List_of_countries_by_life_expe... https://en.wikipedia.org/wiki/List_of_countries_by_alcohol_consumption_per_capita https://en.wikipedia.org/wiki/List_of_countries_by_alcohol_c...
  - mk67 3y ago
    Sounds like bs if you look at Russian numbers.