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Ask HN: What is your experience with Nano-Hydroxyapatite toothpaste?
I have really bad tooth sensitivity and I recently learned about n-Ha toothpaste being a solid treatment for it (mainly the one Boka sells) The fact that n-Ha is the compound that enamel is made of seems really promising but I don’t know enough about it to know if it’ll work and it’s really hard to trust product reviews. Money is in short supply so I really want to make sure I’m not buying into a fad.
I know you all are not dentists or chemists (I’m assuming anyway), but we’ll have the same teeth, so if you happened to use it for a similar purpose and saw good results, I want to know about your experience.
Thank you all.
- linsomniac 3y agoI spoke with my dentist yesterday a bit about nano-Hydroxyapatite. It didn't sound like he had heard about products using it, which I find a little odd because he's the one that mentioned Mi Paste to me 5 years ago. But he's a pretty old guy, he may not be keeping up with the latest. He said chemically it makes sense, and it probably won't do any harm, but he couldn't back it up with any science other than Hydroxyapatite being a component of your enamel. He thought it was probably made from bovine bone, hydroxyapatite being a component of bones as well, but that was just a guess. Seems like Mi Paste has the best science behind it, from what he is aware of. Which again, may not be the most recent. He also recommended Pronamel toothpaste because it's got a lower grit, he said it was 46 where some toothpastes go up to 250. Just a more gentle daily process, if you keep up on your cleanings and everything.
- abrichr 3y agoI use MI Paste. I don't brush with it. Instead I place it in custom teeth whitening trays and let it sit for an hour or so. It's very helpful for reducing sensitivity! I also have Curodont Protect, but haven't tried it yet. Curious to hear others' experiences!
- j-bos 3y agoI'm curious too, so this is more a piggybacking question: Silver diamine is said to be the perfect cavity treatment, cheap, fast, and effective with the only downside being staining of the teeth. Does anyone on HN have silver diamine experiences to share?
- saalweachter 3y agoWhen my oldest daughter began developing cavities in her baby molars, our dentist used silver diamine to stave off putting in a filling until she was older. It was a stopgap measure; it only slowed the decay, not prevent or reverse it, and we had to switch to a three month checkup cycle to monitor the situation and reapply the silver diamine.
- Moldoteck 3y agoBought both apagard royal and apagard premio. I like the taste much more compared to classic ones, but I can't say I've seen some improvements in my teeth, looks the same as when I used Splat or Sesnsodyne protect&repair. Also, consider that apagard usually doesn't have compounds that make your teeth less sensible like other toothpaste Also, fyi- you should not wash your mouth after brushing, just spit the extra paste and wash after ~10-20 mins, this is valid for fluoride variations too Anyway, just buy a tube (start with premio) and see how it goes
- lumb63 3y agoHave tried Boka, Apagard, David’s, and Elims. I have come to much prefer the lack of foaming (I think due to SLS) and they’ve helped my sensitivity slightly. I would recommend them to anyone over fluoride toothpastes due to the possible neurotoxicity of the latter, especially for children.
- Moldoteck 3y agoAfaik boka's concentration of nhap is smaller compared to apagard royal and may offer less protection
- anizan 3y agoUse GC tooth Mousse which is a Japanese product and a well kept secret. My dentist suggested it as the only product with actual results on rebuilding enamel. Most Dentists in USA don't promote this keeping in mind their incentives and it's a 30 year old technology with great results. Pubmed has loads of studies you can pursue. It worked wonders for me. https://www.amazon.com/TOOTH-MOUSSE-X40GM-DENTAL-PRODUCT/dp/B09TB96JMD/ref=sr_1_1?crid=3OUBLNUNKUWZM&keywords=gc+tooth+mousse&qid=1697368903&sprefix=gc+tooth%2Caps%2C595&sr=8-1 https://www.amazon.com/TOOTH-MOUSSE-X40GM-DENTAL-PRODUCT/dp/... There's a newer version called Mi paste which is distributed. https://www.gc.dental/america/products/operatory/preventive/mi-paste-one-perio https://www.gc.dental/america/products/operatory/preventive/...
- Waterluvian 3y agoNow I’m suddenly curious: does enamel regrow the way a precipitate mineral will fill in gaps of a porous rock, or is it a more biological process? Anyways, thanks for the link. I’m going to read then probably try this out.
- bionhoward 3y agoYou got me curious about tooth osteoblasts, some links: https://www.ncbi.nlm.nih.gov/books/NBK572055/#:~:text=The%20enamel%20is%20composed%20mainly,non%2Dvital%20and%20not%20sensitive https://www.ncbi.nlm.nih.gov/books/NBK572055/#:~:text=The%20.... They’re actually called ameloblasts and it seems they do not persist long term (according to our current understanding) “ The cells are part of the reduced enamel epithelium after enamel maturation and then subsequently undergo apoptosis before or after tooth eruption.” from: https://en.wikipedia.org/wiki/Ameloblast?wprov=sfti1#1._Morphogenic_Stage https://en.wikipedia.org/wiki/Ameloblast?wprov=sfti1#1._Morp... However anecdotally, I feel like my teeth did recover from a crack without any dental work
- speedylight 3y agoI think its the former because enamel is a mineral and not living tissue—This is just my uneducated opinion though.
- 3y ago
- ahoka 3y agoIt cured my baldness.
- speedylight 3y agoSilly me, I should’ve looked in the mirror before making this thread.
- bionhoward 3y agoMechanistically, it makes sense. Fluoride is intended to perform a similar role of strengthening the enamel, so it makes sense to directly use the enamel substance as a paste to provide tooth regrowth materials at the site they’re needed. It has helped me with some tooth issues. Research hydroxyapatite toothpaste prevents cavities: https://www.frontiersin.org/articles/10.3389/fpubh.2023.1199728 https://www.frontiersin.org/articles/10.3389/fpubh.2023.1199... In kids: https://www.nature.com/articles/s41598-021-81112-y https://www.nature.com/articles/s41598-021-81112-y Research the same regenerates tooth enamel: https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-019-0454-6 https://jnanobiotechnology.biomedcentral.com/articles/10.118... Another thing which is extremely helpful and I wish I had begun much earlier in life is night mouthguards because grinding your teeth in your sleep even in a subtle way does add up over years and years.
- iforgotpassword 3y ago> Another thing which is extremely helpful and I wish I had begun much earlier in life is night mouthguards because grinding your teeth in your sleep even in a subtle way does add up over years and years. I use one too and usually need replacement about every 18 months. I'm wondering how bad it is to swallow all the plastic. I guess most of it is too big and just moves through the digestive system as is, but I wonder if that grinding also creates particles that are small enough to stay around in the body.
- Ensorceled 3y ago18 months? Wow, mine has lasted 15 years so far. At this point the food chain is so contaminated with microplastics that the amount we are getting from our mouth guards is probably the least of our problems.
- speedylight 3y agoAdd it to the massive pile of other sources of microplastics entering the body, including the air we breathe and food we eat. I’m inhaling microplastics as I write this comment because of my shirt, we’re all fucked!
- 3y ago
- Podgajski 3y agoHey, you know what fixed my tooth sensitivity? Sucking on calcium carbonate tablets, like Tums. The calcium will enter the microtubules and remineralize the teeth. https://www.sciencedirect.com/science/article/pii/S1991790213001360 https://www.sciencedirect.com/science/article/pii/S199179021...
- speedylight 3y agoInteresting idea, is it a permanent fix or do you have to keep doing it?
- Podgajski 3y agoI sometimes have to come back to it, but rarely now, maybe once a year. But I changed many things about my oral and physical health so hard to say what is keeping them mineralized.
- speedylight 3y agoUnderstood. I’ll give it a shot and see how it goes, here’s to eating Ice Cream painfree.
- Podgajski 3y agoPlease let me know if it worked!
- speedylight 3y agoWill do, thank you.
- user_7832 3y agoFWIW if you want a "quick and easy" (not necessarily great/long term) solution, toothpastes like sensodyne do work pretty decently. I had very painful teeth as a kid, reducing (gum/tooth) inflammation + a few weeks of those tooth-sensitivity toothpaste has reduced my sensitivity permanently by a good bit, maybe 60%.
- Faaak 3y agoYou should also try Sensodyne repair and protect. I heard it's not available in the US, but the EU ones contain Novamin which really helps sensitive tooth.
- treecrypto 3y agoMy dentist recommended the same when he thought the issue was just sensitivity.
- rjzzleep 3y agoIn the US and Germany they say there is no solid evidence suggesting that they keep what they promise. I personally use what seems to be an Italian brand called Biorepair and they clearly help with my tooth sensitivities(I have a bad habit of chewing on my nails when stressed). Biorepair seems to have split into an Italian version and a German version with less active ingredients called Bioniq. The Italian versions seems to add xylitol. https://www.amazon.com/s?k=biorepair&i=hpc&crid=3BEZX0VR8DUDG&sprefix=biorepair%2Chpc%2C337&ref=nb_sb_noss_1 https://www.amazon.com/s?k=biorepair&i=hpc&crid=3BEZX0VR8DUD...
- deleted 3y ago[deleted]
- rasz 3y agoRelative bought this toothpaste recently and it looks sketchy AF. No ingredients listed anywhere (clearly violating EU regulations) plus snake oil name. I looked into company and they started making this toothpaste very recently so its not even like they have any experience.
- pps 3y agohttps://www.apacare.com/Remineralising-Toothpaste/1001619 https://www.apacare.com/Remineralising-Toothpaste/1001619 I’ve been using this toothpaste for years and it completely cured my tooth sensitivity issues. I buy it online from the Polish equivalent of Amazon. Looking at people’s reviews, the overwhelming majority are positive, but there are also some negative ones, so it’s definitely not a miracle product.
- DantesKite 3y agoLots of Vitamin D and Vitamin K2 removed most if not all of my tooth sensitivity over the course of a month. About 5 normal Vitamin D pills every few days so. I was trying to treat something else out of desperation and noticed my tooth sensitivity more or less vanished. Which makes sense when considering their role. But as always, n=1.
- speedylight 3y agoThis is really interesting to me because D helps in Calcium and Phosphate (building blocks of enamel) absorption, and K2 helps in using them to build bone. If they really were the only culprit in ridding you of your sensitivity than that means your body regenerated Enamel on its own. n=1 aside your comment gives me renewed faith in the human body. What brand of K2 and Vitamin D did you use?
- DantesKite 3y agoBulk Supplements, but mostly because they're the cheapest per gram I can find. I don't think you need anything fancy per se.
- FleursDuMal 3y agoI found the same thing, taking K2 (the Carlson labs MK-4 version) with some D3 drops helped hugely.
- tomatocracy 3y agoBe careful with very high doses of vitamin D supplements if you have a family history of heart disease - over the long term it can increase calcium buildup elsewhere as well, which can damage the heart (amongst other things).
- Perceval 3y agoI have been using Dr. Jen's Super Paste: https://drjennatural.com/products/dr-jen-super-paste-with-nano-hydroxyapatite-fluoride https://drjennatural.com/products/dr-jen-super-paste-with-na... I landed on this one out of all the N-Ha brands because it also has flouride. Also, it doesn't have SLS, which I feel good about. I used to need Sensodyne to manage tooth sensitivity. I would go out of my way to buy Canadian or UK Sensodyne with Novamin, since the Novamin formulations aren't sold in the U.S. However, Jen's has eliminated the tooth sensitivity without needing a numbing agent like Sensodyne, which was surprising to me. I've stuck with Jen's even though it's more expensive. I can't speak to whether it's strengthened my enamel appreciably, but my teeth feel much better.
- theNewMicrosoft 3y ago> Also, it doesn't have SLS, which I feel good about. Fwiw, the jury is still out regarding SLS. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506142/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506142/
- novia 3y agoAnecdota: SLS always causes mouth sores aka canker sores for me. My inner cheeks and gums were covered in them before I figured it out. It was a very painful existence. Other people online reporting that cutting it out helped them saved me. I'm sure there are people who can tolerate SLS just fine, but I am not one of them, and the evidence has been clear cut enough for me that an inconclusive NIH study will do nothing to move the needle. For anyone reading this suffering the same fate, benzocaine, which is commonly sold near the toothpastes, is an absolute lifesaver when you have a canker sore. It's sold under the name "Kanka" but any store brand alternatives should work just as well.
- bilsbie 3y agoIs this the same as novamin? If not which might be better?
- rsync 3y agoNovamin is Bioglass 45S5 or calcium sodium phosphosilicate[1] which is not the same thing. [1] https://en.wikipedia.org/wiki/Bioglass_45S5 https://en.wikipedia.org/wiki/Bioglass_45S5
- darkhorn 3y agoDon't drink soda. Drink water.It will create a protective layer for few hours.
- fallinghawks 3y agoTo be fair I don't really have any real problems with my teeth apart from having had an overeager/greedy childhood dentist who put in a ton of fillings, making for a lifetime of occasionally having to redo one and needing 2 crowns. I switched to Apagard about 8 months ago. My hygienist seemed happy about it. I like the fact that it's not overwhelmingly minty like most American toothpastes and doesn't foam up too much. I think if I manage to avoid needing new fillings or a redo for 6-7 years (about the frequency at which I need one) I would consider it a good switch.
- speedylight 3y agoDamn greedy dentists are some of worst kinds of people imo. It’s like in their head they swore to do harm, not the opposite.
- ProjectArcturis 3y agoDentists don't even take the Hippocratic Oath in the first place.
- ravenstine 3y agoKnowing what I know now about dentistry, I would only ever let a dentist drill a tooth where I can actually see decay. If I can't see it, and the X-ray looks dubious, I'd just outright refuse. And then I'd see another dentist.
- fallinghawks 3y agoExactly. One time I skipped out in 2-3 years of cleaning while dithering on finding a dentist in the new area I moved to. She presented me with an estimate involving about 8 fillings. (I had specifically asked her to keep to the necessary ones.) Shocked, I went back to my old dentist for a second opinion. He told me most of them must be just replacing amalgams with porcelain because he couldn't find any actual new decay.
- theNJR 3y agoSince we are talking dental health, any insights into gingival recession? I think my gums have receded due to brushing them too hard over the years. You can’t tell unless you flip my gums back.
- speedylight 3y agoOh boy that’s another beast I am trying to slay. All I keep hearing is that once gums start receding there’s no regenerating it, only stopping it from getting worse and I just have a hard time buying such a simple explanation. It could be hubris talking, I can’t really tell you one way or the other. Uneducated Speculation: My theory is that the gums can regenerate and regain attachment loss but only in the right conditions -> in practice that would mean that they are not inflamed, and clean underneath the gum line (you can do that by flossing and getting a deep cleaning at a dentist if you need one), as well as doing your best to eliminate harmful bacteria that turn into calculus, and having a healthy diet. The trickiest part is probably selectively eliminating the bad bacteria while retaining the good ones The mouth is full of both and mouthwashes like Listarine, or any Alcohol based ones are sledgehammers. Some washes are too harsh on the tissue itself too which I imagine impairs healing of any kind.
- manmal 3y agoXylitol does selectively inhibit some bad strains, and some oral probiotics (K2 BLIS, L. Sakei, B. Subtilis) are quite aggressive in killing off other species. Might also be worth looking into all the substrates required for bone and connective tissue building, apart from the obvious (calcium, magnesium), e.g. silica, iron and copper.
- speedylight 3y agoDo you think the Xylitol in gum is good enough for that?
- manmal 3y agoProbably yes? Avoid fructose for a while before and after because that allows bacteria to avoid xylitol uptake.
- speedylight 3y agoI’m so glad I made this thread, a wealth of information and recommendations from many people. I no longer feel my situation is hopeless, thank you guys.
- esaym 3y agoUse Sensodyne with novamin. You can get the Canadian version on ebay.
- shmde 3y agoDoes the canadian version say "thank you" after you brush with it ?
- navjack27 3y agoI use a sensodyne toothpaste that has biomin in it. I'm not good about brushing and every once in a while the right side of my face hurts around my upper or lower molars or something and I'll remember to brush again and take an Aleve and it goes away within a day or two.
- Freak_NL 3y agoDo you have an electric toothbrush? It helps with timing and is generally considered to brush better. But really, get back into the habit of brushing your teeth twice daily. It's one investment that pays of hugely in avoided trouble and costs.
- TheAdamist 3y agoWhich sensodyne and which country is it from? Their product lines seems intentionally opaque.
- 34823054950 3y agoSince no one's mentioned it yet - I had really sensitive gums for a while, and it was because I was very anemic, after the anemia was dealt with the sensitivity was gone. So if you have other symptoms of anemia also (fatigue, random dizziness, wanting to chew ice, etc) & haven't had it checked in a while maybe ask your doctor about it.
- speedylight 3y agoCan anemia be detected with the blood tests you get at annual check up?
- bookmtn 3y agoCBC - Complete Blood Count is a common, routine test that detects anemia. https://www.healthline.com/health/anemia/anemia-blood-test#blood-tests https://www.healthline.com/health/anemia/anemia-blood-test#b...
- hackily 3y agoI use apagard premio, came across it while doing research a couple of years ago (4-5) on nano hydroxyapatite. I've never really had problems with my adult teeth and I continue to not have problems, so at the very least, in my case, is not any worse than fluoride toothpaste. My dentist loves my teeth :D she told me whatever I'm doing, don't change a single thing.
- Anaid__ 3y agoI've been using a tooth paste with hydroxypatite for a little more than one year. Mostly for the enamel in my front teeth. I can see it works to some extend. The corrosion from the upper side of the teeth have stopped and I can see improvement of the already eroded side but I am talking about less than a milimiter. It is not a quick solution, and it requires dental higyne routinely. As for the price, I found that of you get the tooth paste in bulk it is more affordable.
- bookmtn 3y agoOn the topic of toothpaste, I developed a reaction to SLS - Sodium Laurel Sulfate. That's when I switched to Sensodyne, because it doesn't contain SLS. For awhile, Sensodyne was a problem and I began using Baking Soda. Then returned to Sensodyne after a few weeks. Before this sensitivity, someone asked if I whitened my teeth because they were whiter. Using an electric toothbrush changed the color of my teeth for the better. A Water-Pik helps the gums rejuvenate as does flossing.
- ddmf 3y agoSLS - as well as being the thing that makes orange juice taste rank after you've brushed your teeth - also gives me huge mouth ulcers (canker sores). Sensodyne has been amazing for this. Someone also mentioned a water pik is great for tonsililiths too.
- electrondood 3y agoWhile we're here, I'd like to point out that the medium chain triglycerides in coconut oil are AS EFFECTIVE of an antimicrobial as the most common prescription dental mouthwash Chlorhexidine [0]. [0] https://pubmed.ncbi.nlm.nih.gov/27891311/#:~:text=The%20study%20also%20showed%20that%20in%20comparison%20of%20coconut%20oil%20and%20chlorhexidine%20there%20is%20no%20statistically%20significant%20change%20regarding%20the%20antibacterial%20efficacy https://pubmed.ncbi.nlm.nih.gov/27891311/#:~:text=The%20stud....
- speedylight 3y agoIs the design of the study good? I don’t really know how to tell one way or the other.
- pas 3y agoImportant things to check when it comes to experiments - preregistration (it helps to counter fishing-for-signal bias, ie. maybe there were 1000 kids, and they only picked this 50 young girls, because this is where there's a big positive effect; also statistical significance levels, how much "sigma" is needed to say that the null hypothesis can be rejected) - control group (here there's a nice direct comparison group, but there's no no-treatment group) - blinding (did the kids know which one they were using? of course, but let's say it's not really relevant here, and they even mention that "no concealment was possible") - power analysis (if we want to demonstrate a small effect we need a large sample size, power analysis can tell us was the experiment even capable of producing significant results or not, because it was underpowered? this requires an estimation of the effect size from the hypothesis) - basics causal inference sanity checks (are they making claims/conclusions that are actually supported by the data? is the experiment even capable of showing any kind of causal direction? due to the lack of no-treatment group we don't really know if the decrease in the numbers is due to weather or the treatments, so in this regard if we want to be very pedantic, it's a bit of a stretch to say that the treatments caused the decrease, but it's true that there was a significant decrease) - stats check (they are using "Wilcoxon matched pairs signed ranks test" ... which is good for exactly this kind of "is there an effect at all" hypothesis testing (and arguably better than a t-test, because this is ranked data, not pulled from some nice normal distributions), basically it says that how likely it is that the day 0 and day 30 numbers are "really different", and we see that they got p-values smaller than 0.001, which indicates that it's very unlikely that they are from the same distribution; and then there's also a test for comparing the groups, but I haven't checked that) Also, we can look at the full-text to see the numbers: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109859/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109859/ it's interesting that there's a typo in deviation in Table 1, but not in the others, but there's also one in Whitney in Table 6 :) all in all seems okay, though I think a nice chart would have been good with error bars and effect sizes (because then you can see that the treatment arms leave the null hypothesis region, and by how much, like with this one https://cdn.the-scientist.com/assets/articleNo/69229/iImg/43670/mrna-vaccine-infection-comparison-o.jpg https://cdn.the-scientist.com/assets/articleNo/69229/iImg/43... ) of course, it's just one study ... https://slatestarcodex.com/2014/12/12/beware-the-man-of-one-study/ https://slatestarcodex.com/2014/12/12/beware-the-man-of-one-...
- artificialLimbs 3y agoWhen my teeth get too sensitive I swish with clove oil and that works well. I put a couple drops of oil in the bottom of a glass and fill it with about a cup of water.
- deleted 3y ago[deleted]
- beaugunderson 3y agoHad been using Apagard Premio n-Ha toothpaste since 2020. Ended up with 8 cavities in early 2023, largely due to two factors: consistently drinking one sugar free Red Bull in the morning, my critical error here was in drinking it SLOWLY over the course of one hour... no one ever taught me about the Stephan curve or why keeping your mouth in an acidic state could be disastrous for your teeth. The other factor was grinding my teeth at night, and a bite guard has somewhat helped there. Ideal would be not grinding but I don't have a magic solution there. Dentist prescribed fluoride toothpaste and MI paste. My tooth sensitivity is now gone.
- imhoguy 3y agoAnegdotal, but my grinding went almost away when I stopped eating a few hours before sleep, started cardio exercising and in general reducing daily stress. My wife tells me it rarely comes back but with some really bad stress or drinking too much before, then snoring also hits.
- stevenae 3y agoI started using Uncle Harry's, after having a sensitive crisis and being told by a dentist that I would need extensive crowns. That was... 7 years ago? Got one cavity done last year. Surprised no one else had mentioned them. American, reputable, easy to find.
- kukkeliskuu 3y agoI have tried Boka, but ultimately decided to stop using it. Don’t really have enough data to recommend or not recommend it. I have used BioPure ozone ooth paste and that is excellent, just dfficult to get to the EU. https://store.biopureus.com/products/tooth-and-gum-paste?variant=41574367756477 https://store.biopureus.com/products/tooth-and-gum-paste?var...
- an_aparallel 3y agoThere are spot treatments which general dentists do not have access to - which you must go to a periodontist for. My back molar had some bad sensitivity - and i could not risk loosing it before a major dental surgery - so i had this treatment done. These spot treatments (topical) last for 4-6 months. Going to a perio will cost you though (obviously)