4 ms·

This has been beaten to death in high quality randomized controlled trials in sepsis. Don’t believe a university press release lol. HN is a pretty poor source o

• olliej 3y ago
  Look, if you can't trust university press releases posted to a tech forum for health advice, who can you trust?
  • callalex 3y ago
    I take all of my health advice exclusively from statistical language models.
    • serf 3y ago
      joking aside, I have met a few GPs in my life that were just about at that caliber of expertise.
    • fuyrsvbg 3y ago
      There are several reasons why you may take all of your health advice from statistical language models.
  • nradov 3y ago
    I usually trust podcasts hosted by comedians and retired athletes.
• deeviant 3y ago
  Beaten to death as in proven, or disproven?
• letmevoteplease 3y ago
  The study says: "Randomized controlled trials, however, have shown variable results or even possible harm [10,11,12]. Moreover, current guidelines and a Bayesian re-analysis of a previous trial have led to recommendations not to use intravenous vitamin C in patients with sepsis because of possible harm [13, 14]. Regrettably, these studies used ascorbic acid, a compound associated with the induction of metabolic acidosis and acidemia [15]. This makes it uncertain whether the unclear effects in human sepsis were due to the administration of a suboptimal preparation of the study medication. In contrast, sodium ascorbate (NaAscorbate) has a physiological pH, does not contribute to acidosis, can be given at a much greater dose, and may carry a different efficacy profile [16]." https://ccforum.biomedcentral.com/articles/10.1186/s13054-023-04644-x https://ccforum.biomedcentral.com/articles/10.1186/s13054-02...