14 ms·

I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great a

by jmpman 3y ago

I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself to keep drinking, say if my good friends are in town and we’re going out all night? Sure, but there’s some reward center that’s no longer lighting up. I just get drunker, but it’s not more pleasurable. I was never a big drinker at home by myself. Maybe a glass of wine or two with dinner if my in-laws are coming over. Now I’ve literally had zero drinks at home by myself. Seems to have started changing about 3 month in. Work also seems more interesting, but my untreated ADHD seems to be getting worse.

raincom 3y ago
I heard Mounjaro is even more effective than Semaglutide.
yieldcrv 3y ago
the most surprising thing to me is how you’re describing normal behavior that I can relate to all my life, but the community of strugglers is so big that this is a whole testimonial people feel comfortable and exalted to share like thats not something I’m deriding its just news to me makes me wonder what this drug actually does, flush gut bacteria? just the right ones?
- andbberger 3y ago
  it's a GLP-1 agonist
  - 015UUZn8aEvW 3y ago
    Ozempic/Wegovy is a GLP-1 receptor agonist, but Mounjaro is a GLP-1 and GIP receptor agonist
- ramraj07 3y ago
  For a long time we have known the existence of a network of hormones controlling our apetite on the gut brain axis, with names like ghrelin, leptin, glp-1, orexin, somatostatin, list goes on [1]. Issue was the network was tres complicé and hard to perturb without getting the opposite effect than what we wanted. Finally with glp-1, sglt2 and pcsk9 inhibition we are starting to be able to correct in the right way. To answer your question, yeah turns out it was never about will power. Some people just had hormone drive to be healthier than others and finally we can pharmacologically start to level the field. 1. https://www.cell.com/cell/pdf/S0092-8674(14)01503-7.pdf https://www.cell.com/cell/pdf/S0092-8674(14)01503-7.pdf
  - yieldcrv 3y ago
    can we do this for working out and exercise? I’m lean but dont do that and can recognize the benefits. It would be cool if we could pharmacologically make that appealing too. What if we could just continually swap in states. Executive work mode, ah it feels so good to think and focus. Empath mode, ah it feels so good to build relationships. Brolic mode, ah it feels so good to think about working out, and actually work out!
    - Red_Leaves_Flyy 3y ago
      Do you want to live in the world of we happy few? This is what you’re suggesting with your rose colored glasses. What would really happen is companies would get the drug legalized so they can pump into their employees.
      - yieldcrv 3y ago
        Then some people would feel there is a lopsided power dynamic in their choice to take them. In the meantime I would like that choice from a purely self preservation interest in being good at other bodily health and resource appropriations
    - Earw0rm 3y ago
      Find the right exercise/workout for you and it'll be its own reward. Shouldn't take more than a bit of caffeine to get you moving at that point. As to empath mode, you've just described MDMA. But it'd be nice if there were something a little less intense. That you could take weekly without frying your brain & was mild enough for family/work social situations. (And no, alcohol doesn't fit the bill).
- reaperman 3y ago
  Any effects on gut bacteria will be very downstream of its primary effects, which are on: - GLP-1 (semaglutide) - optionally, that and also GIP (tirzepatide) - optionally, both of those and also glucagon receptor (retatrutide) But these hormones directly make you not hungry, among other things. They are probably some of the things that your gut bacteria manipulate to commandeer your behavior.
paulpauper 3y ago
Good job, nice to see it works on reducing alcohol consumption too. I do not need this drug but it's nice knowing the option exists it need be. It gives hope to others too.
remote_phone 3y ago
I heard that 2/3 of the weight loss is muscle, do you find that to be the case?
- paulpauper 3y ago
  this is likely incorrect because people are confusing lean body weight loss for muscle loss. lean body weight loss does not mean only muscle loss. lean weight includes non muscle like skin, organs, etc.
  - adamduren 3y ago
    Drugs that target the GLP-1 and GIP pathways can suppress appetite, potentially leading to a significant caloric deficit. This can lead to the body to break down muscle tissue to obtain protein for energy which could lead to a loss of lean muscle mass However, maintaining regular exercise and consuming sufficient protein can help to minimize the impact of lean muscle mass loss
    - sjtgraham 3y ago
      Protein is not what the body reaches for first in the absence of glucose/glycogen.
      - sn9 3y ago
        This is true but it's still extremely well established that you lose some muscle along with fat if you're in a prolonged caloric deficit without sufficient protein and strength training.
  - pasquinelli 3y ago
    not just lost muscle mass, but also lost organ mass?
    - imtringued 3y ago
      If that means visceral fat then it would be a godsend.
usernew 3y ago
If you're interested - not pushing an agenda. Here's what worked for this weird dude to not drink and stay fit. I used to lift and be real fit till about 40. Like bulky-lean looking, bench 400 10x with a 6pack. Had a lot to do with being on the road for work all over the world, and you sit at the gym at the hotel for an hour every night because of nothing else to do, and there are girls there also on business who you'll never see again. I drank A Lot, ate anything I wanted, and did lots of blo on weekends. It was getting out of control, so I did months of google-foo, went to a pharmacy in eastern europe, got like a thousand 150mg disulfiram pills under the counter for fifty bucks, and took one pill every morning for 2 years. You don't drink, you can't drink or you die, you forget drinking exists and after a couple of months don't even think about it, yet still do all the same stuff you used to - like dancing and clubs if that's your thing. And it's even more fun. There were no side effects. Then things changed with age, testosterone went to crap, joints hurt. I got married and settled down. Can't work out too much now - just a couple of hours per week, and no heavy weights. Within 2 years I couldn't fit into my clothes and had high blood pressure and high cholesterol. I realized I don't eat because I'm hungry, but because it keeps away sadness. So I changed my diet so I could eat however much I want. I now have a 4-pack instead of 6, fit into my pants, and eat however much I want. I cut out fat completely. No oil when I cook besides a light spray on the frying pan. No nuts. Tuna - not salmon. Real expensive lean filet if I want cow in my mouth. Only white meat from birds. All the pasta, rice, and potatoes I want, but zero sugar added to anything. Lots of splenda and sweet n low. Fat free fairlife milk (lactose filtered out = less sugar calories). I eat normal sized meals. Then, I have fruit and berries, and I eat as much of that as I want. I'm stuffing my face the whole day. Today, I had a pint of blueberries, 5 medium apples, 2 mangoes, and a pound of grapes. Speaking of gastrointestinal issues, my poo is now soft and gentle, and smells delicious.
- tysam_and 3y ago
  That last line does not belong on most respectable websites on the internet.
  - water9 3y ago
    If he hasn't learned by now, your post isn't going to teach him
helsinkiandrew 3y ago
> but there’s some reward center that’s no longer lighting up. Do you find other pleasures (non food and drink) as enjoyable? Interesting to hear if it’s selective or dampens everything.
- jmpman 3y ago
  Sex, sure. Video games - maybe.
rblatz 3y ago
I started taking it in November and I’m down 30 pounds and my retina has detached 2x for no apparent reason since then. My drinking is unchanged, except I get full sooner and drink slower. Because of the discomfort.
- ShadowBanThis01 3y ago
  "my retina has detached 2x for no apparent reason since then" I'd say that's a pretty huge deal. Did you report that?
- eshack94 3y ago
  Oh my, is retinal detachment a known potential side effect of the drug? Or is that a complication of diabetic retinopathy or some other condition that you already had? This sounds frightening. Hope they were able to reattach it, and hope you're doing alright.
  - cmcaleer 3y ago
    I can’t find the specific study this website cites, but it mentions: > In a 2-year trial among patients with type 2 diabetes and high cardiovascular risk, patients treated with this drug experienced a great incidence of diabetic retinopathy complications (3% vs 1.8%). The absolute risk was greater in patients with a history of diabetic retinopathy at baseline (8.2%[drug] vs 5.2%[placebo]) than those without (0.7%[drug] vs 0.4%[placebo]). https://www.drugs.com/sfx/semaglutide-side-effects.html https://www.drugs.com/sfx/semaglutide-side-effects.html Would be very interested in knowing the commenter’s diabetes status.
    - rblatz 3y ago
      Non diabetic, didn’t/don’t have diabetic retinopathy. I had assumed that the detachments were unrelated to Semaglutide but just happened as a freak coincidence in time. The no apparent reason was a bit of hyperbole, since my vitreous was pulling away from the retina and brought some pieces with it during the process. But as to why that was happening at my current age is unknown. Second was likely related to stress in the eye from healing from the first surgery. But the point was I didn’t take any blows to the head or eye, or any other common cause of retinal detachments.
CapstanRoller 3y ago
>I feel great and my brain seems to be functioning as well as when I was in my 20’s >but my untreated ADHD seems to be getting worse. I had very similar results after taking ketamine for treatment-resistant depression. It eliminated all my compulsive tendencies for getting cheap dopamine hits (food, doomscrolling, etc), reset my tolerance to everything (caffeine, ADHD meds, alcohol), and made my ADHD worse while improving throughput and ability to Get Shit Done. I wonder if they affect the same parts of the brain in a roundabout way? Ketamine is also used to treat addiction (opioids, primarily). Do you experience any anhedonia while using Mounjaro? Did your overall pleasure response get blunted?
- 36933 3y ago
  Ketamine treatments help people, because ketamine is a dissociative drug. It makes you not feel your suffering, also makes you not feel the positive feelings. That’s why you’re not eg doomscrolling. It doesn’t feel good for you anymore. If you’re not getting treatments regularly, you will be back to suffering in a few months likely. In my opinion, there are better alternatives and more effective treatments than living a life of disassociation.
  - valec 3y ago
    this is not true at all. the dissociative effects only last a few hours. the clinical benefit is because ketamine stimulates neurogenesis in the mPFC and hippocampus, restoring plasticity lost in depressed patients. don't make unsubstantiated leaps :-)
    - deleted 3y ago
      [deleted]
    - 36933 3y ago
      Yes the immediate effects last for a few hours. I didn’t say otherwise. The current scientific literature paints a mixed picture of ketamine. While it can stimulate neurogenesis, there is a definite potential for neurotoxicity. Not to mention that there are no long term studies out there. There are countless people reporting being anhedonic after treatments. Only a few people have been reported to not relapse before 24 weeks. I’m not making unsubstantiated claims. Don’t accuse me of that, because you don’t like my answer.
c7DJTLrn 3y ago
Based on what you've said it sounds like the drug may have an effect on release of dopamine, though I'm sure the trials would have caught that if so.

by jmpman 3y ago

raincom 3y ago

I heard Mounjaro is even more effective than Semaglutide.

yieldcrv 3y ago

the most surprising thing to me is how you’re describing normal behavior that I can relate to all my life, but the community of strugglers is so big that this is a whole testimonial people feel comfortable and exalted to share like thats not something I’m deriding its just news to me makes me wonder what this drug actually does, flush gut bacteria? just the right ones?

andbberger 3y ago
it's a GLP-1 agonist
- 015UUZn8aEvW 3y ago
  Ozempic/Wegovy is a GLP-1 receptor agonist, but Mounjaro is a GLP-1 and GIP receptor agonist
ramraj07 3y ago
For a long time we have known the existence of a network of hormones controlling our apetite on the gut brain axis, with names like ghrelin, leptin, glp-1, orexin, somatostatin, list goes on [1]. Issue was the network was tres complicé and hard to perturb without getting the opposite effect than what we wanted. Finally with glp-1, sglt2 and pcsk9 inhibition we are starting to be able to correct in the right way. To answer your question, yeah turns out it was never about will power. Some people just had hormone drive to be healthier than others and finally we can pharmacologically start to level the field. 1. https://www.cell.com/cell/pdf/S0092-8674(14)01503-7.pdf https://www.cell.com/cell/pdf/S0092-8674(14)01503-7.pdf
- yieldcrv 3y ago
  can we do this for working out and exercise? I’m lean but dont do that and can recognize the benefits. It would be cool if we could pharmacologically make that appealing too. What if we could just continually swap in states. Executive work mode, ah it feels so good to think and focus. Empath mode, ah it feels so good to build relationships. Brolic mode, ah it feels so good to think about working out, and actually work out!
  - Red_Leaves_Flyy 3y ago
    Do you want to live in the world of we happy few? This is what you’re suggesting with your rose colored glasses. What would really happen is companies would get the drug legalized so they can pump into their employees.
    - yieldcrv 3y ago
      Then some people would feel there is a lopsided power dynamic in their choice to take them. In the meantime I would like that choice from a purely self preservation interest in being good at other bodily health and resource appropriations
  - Earw0rm 3y ago
    Find the right exercise/workout for you and it'll be its own reward. Shouldn't take more than a bit of caffeine to get you moving at that point. As to empath mode, you've just described MDMA. But it'd be nice if there were something a little less intense. That you could take weekly without frying your brain & was mild enough for family/work social situations. (And no, alcohol doesn't fit the bill).
reaperman 3y ago
Any effects on gut bacteria will be very downstream of its primary effects, which are on: - GLP-1 (semaglutide) - optionally, that and also GIP (tirzepatide) - optionally, both of those and also glucagon receptor (retatrutide) But these hormones directly make you not hungry, among other things. They are probably some of the things that your gut bacteria manipulate to commandeer your behavior.

paulpauper 3y ago

Good job, nice to see it works on reducing alcohol consumption too. I do not need this drug but it's nice knowing the option exists it need be. It gives hope to others too.

remote_phone 3y ago

I heard that 2/3 of the weight loss is muscle, do you find that to be the case?

paulpauper 3y ago
this is likely incorrect because people are confusing lean body weight loss for muscle loss. lean body weight loss does not mean only muscle loss. lean weight includes non muscle like skin, organs, etc.
- adamduren 3y ago
  Drugs that target the GLP-1 and GIP pathways can suppress appetite, potentially leading to a significant caloric deficit. This can lead to the body to break down muscle tissue to obtain protein for energy which could lead to a loss of lean muscle mass However, maintaining regular exercise and consuming sufficient protein can help to minimize the impact of lean muscle mass loss
  - sjtgraham 3y ago
    Protein is not what the body reaches for first in the absence of glucose/glycogen.
    - sn9 3y ago
      This is true but it's still extremely well established that you lose some muscle along with fat if you're in a prolonged caloric deficit without sufficient protein and strength training.
- pasquinelli 3y ago
  not just lost muscle mass, but also lost organ mass?
  - imtringued 3y ago
    If that means visceral fat then it would be a godsend.

usernew 3y ago

If you're interested - not pushing an agenda. Here's what worked for this weird dude to not drink and stay fit. I used to lift and be real fit till about 40. Like bulky-lean looking, bench 400 10x with a 6pack. Had a lot to do with being on the road for work all over the world, and you sit at the gym at the hotel for an hour every night because of nothing else to do, and there are girls there also on business who you'll never see again. I drank A Lot, ate anything I wanted, and did lots of blo on weekends. It was getting out of control, so I did months of google-foo, went to a pharmacy in eastern europe, got like a thousand 150mg disulfiram pills under the counter for fifty bucks, and took one pill every morning for 2 years. You don't drink, you can't drink or you die, you forget drinking exists and after a couple of months don't even think about it, yet still do all the same stuff you used to - like dancing and clubs if that's your thing. And it's even more fun. There were no side effects. Then things changed with age, testosterone went to crap, joints hurt. I got married and settled down. Can't work out too much now - just a couple of hours per week, and no heavy weights. Within 2 years I couldn't fit into my clothes and had high blood pressure and high cholesterol. I realized I don't eat because I'm hungry, but because it keeps away sadness. So I changed my diet so I could eat however much I want. I now have a 4-pack instead of 6, fit into my pants, and eat however much I want. I cut out fat completely. No oil when I cook besides a light spray on the frying pan. No nuts. Tuna - not salmon. Real expensive lean filet if I want cow in my mouth. Only white meat from birds. All the pasta, rice, and potatoes I want, but zero sugar added to anything. Lots of splenda and sweet n low. Fat free fairlife milk (lactose filtered out = less sugar calories). I eat normal sized meals. Then, I have fruit and berries, and I eat as much of that as I want. I'm stuffing my face the whole day. Today, I had a pint of blueberries, 5 medium apples, 2 mangoes, and a pound of grapes. Speaking of gastrointestinal issues, my poo is now soft and gentle, and smells delicious.

tysam_and 3y ago
That last line does not belong on most respectable websites on the internet.
- water9 3y ago
  If he hasn't learned by now, your post isn't going to teach him

helsinkiandrew 3y ago

> but there’s some reward center that’s no longer lighting up. Do you find other pleasures (non food and drink) as enjoyable? Interesting to hear if it’s selective or dampens everything.

jmpman 3y ago
Sex, sure. Video games - maybe.

rblatz 3y ago

I started taking it in November and I’m down 30 pounds and my retina has detached 2x for no apparent reason since then. My drinking is unchanged, except I get full sooner and drink slower. Because of the discomfort.

ShadowBanThis01 3y ago
"my retina has detached 2x for no apparent reason since then" I'd say that's a pretty huge deal. Did you report that?
eshack94 3y ago
Oh my, is retinal detachment a known potential side effect of the drug? Or is that a complication of diabetic retinopathy or some other condition that you already had? This sounds frightening. Hope they were able to reattach it, and hope you're doing alright.
- cmcaleer 3y ago
  I can’t find the specific study this website cites, but it mentions: > In a 2-year trial among patients with type 2 diabetes and high cardiovascular risk, patients treated with this drug experienced a great incidence of diabetic retinopathy complications (3% vs 1.8%). The absolute risk was greater in patients with a history of diabetic retinopathy at baseline (8.2%[drug] vs 5.2%[placebo]) than those without (0.7%[drug] vs 0.4%[placebo]). https://www.drugs.com/sfx/semaglutide-side-effects.html https://www.drugs.com/sfx/semaglutide-side-effects.html Would be very interested in knowing the commenter’s diabetes status.
  - rblatz 3y ago
    Non diabetic, didn’t/don’t have diabetic retinopathy. I had assumed that the detachments were unrelated to Semaglutide but just happened as a freak coincidence in time. The no apparent reason was a bit of hyperbole, since my vitreous was pulling away from the retina and brought some pieces with it during the process. But as to why that was happening at my current age is unknown. Second was likely related to stress in the eye from healing from the first surgery. But the point was I didn’t take any blows to the head or eye, or any other common cause of retinal detachments.

CapstanRoller 3y ago

>I feel great and my brain seems to be functioning as well as when I was in my 20’s >but my untreated ADHD seems to be getting worse. I had very similar results after taking ketamine for treatment-resistant depression. It eliminated all my compulsive tendencies for getting cheap dopamine hits (food, doomscrolling, etc), reset my tolerance to everything (caffeine, ADHD meds, alcohol), and made my ADHD worse while improving throughput and ability to Get Shit Done. I wonder if they affect the same parts of the brain in a roundabout way? Ketamine is also used to treat addiction (opioids, primarily). Do you experience any anhedonia while using Mounjaro? Did your overall pleasure response get blunted?

36933 3y ago
Ketamine treatments help people, because ketamine is a dissociative drug. It makes you not feel your suffering, also makes you not feel the positive feelings. That’s why you’re not eg doomscrolling. It doesn’t feel good for you anymore. If you’re not getting treatments regularly, you will be back to suffering in a few months likely. In my opinion, there are better alternatives and more effective treatments than living a life of disassociation.
- valec 3y ago
  this is not true at all. the dissociative effects only last a few hours. the clinical benefit is because ketamine stimulates neurogenesis in the mPFC and hippocampus, restoring plasticity lost in depressed patients. don't make unsubstantiated leaps :-)
  - deleted 3y ago
    [deleted]
  - 36933 3y ago
    Yes the immediate effects last for a few hours. I didn’t say otherwise. The current scientific literature paints a mixed picture of ketamine. While it can stimulate neurogenesis, there is a definite potential for neurotoxicity. Not to mention that there are no long term studies out there. There are countless people reporting being anhedonic after treatments. Only a few people have been reported to not relapse before 24 weeks. I’m not making unsubstantiated claims. Don’t accuse me of that, because you don’t like my answer.

c7DJTLrn 3y ago

Based on what you've said it sounds like the drug may have an effect on release of dopamine, though I'm sure the trials would have caught that if so.