14 ms·

I’m glad people are enjoying Ozempic. My experience from seeing a family member on it, is I would not touch it if I were a 500-pound alcoholic smoking two packs

by lumb63 3y ago

I’m glad people are enjoying Ozempic. My experience from seeing a family member on it, is I would not touch it if I were a 500-pound alcoholic smoking two packs of cigarettes a day. That’s an exaggeration since it probably outweighs the health issues there, but only slightly. The person I know taking Ozempic has only lost weight (35 lbs) due to the fact that eating now makes her sick. She has been sapped of all energy and has developed issues with her bladder, circulatory system, joints, thyroid, and digestive system since starting Ozempic. I’m not saying it’s due to Ozempic, but I am saying all these issues have cropped up in the few months since she started taking it, and she never had any chronic health issues prior. At least she lost some weight, I guess.

ikekkdcjkfke 3y ago
Same experience here, gallstone attacks
- shrimp_emoji 3y ago
  You can get those from rapid weight loss, I thought. Maybe it's working TOO well if that's the case.
  - jjeaff 3y ago
    Ya, rapid weight loss is one of the most common triggers of gall stones. Lots of weight loss surgery patients get them as well.
    - winocm 3y ago
      Happened to me too from just generally not eating much at the time. Ended up getting acute cholecystitis and a dead gallbladder plus sepsis after. Not too pleasant of an experience.
burnte 3y ago
I take it, and when I started I got violently nauseous and had GI issues. I wasn't informed I needed to slowly ramp up. I still have pretty big appetite suppression, and only minimal nausea sometimes if I eat too much, but what it's done to my blood glucose is AMAZING. And I lost some weight when I started which was a great bonus. It can be hard to start but it's truly worth it, just adjust the dose. I take 0.5mg as I can't handle the larger 1.0mg dose.
- reaperman 3y ago
  > I wasn't informed I needed to slowly ramp up. In a fair world that would be considered severe malpractice :-( It's nearly common knowledge. A huge number of people are suffering under these medications because of starting at a dose to high or raising doses too quickly / too much at a time. LY3437943 looks even more promising, with fewer side effects. Semaglutide will probably have the most side effects because it only has one action (GLP-1 agonist). Tirzepatide has slightly lower side effects because it adds a dual action (GLP-1 agonist + GIP analogue) so it can act at a lower magnitude on the GLP-1 receptors to avoid strong side effects, while still having higher efficacy due to its additional, separate, GIP action. LY3437943 retains both the actions of Tirzepatide but adds a third action, glucagon receptor agonist. So it should be able to have higher efficacy at a lower equivalent dose than the other two (less action on GLP-1 and GIP mechanisms, fewer side effects).
kristofferR 3y ago
While others have none or barely any side effects, it is a drug after all. For those people who tolerate the drug well, it can be revolutionary in their lives, but it's unfortunately not a good fit for everyone. I hope your family member gets better soon.
ortusdux 3y ago
>>due to the fact that eating now makes her sick. Reminds me of the first FDA approved weight loss drug, Alli, that basically just gastrointestinally punishes you if you eat more than a few grams of fat. https://en.wikipedia.org/wiki/Orlistat#Side_effects https://en.wikipedia.org/wiki/Orlistat#Side_effects
- spondylosaurus 3y ago
  > The manual for Alli makes it clear that orlistat treatment involves aversion therapy, encouraging the user to associate eating fat with unpleasant treatment effects. Christ. This is like Crohn's disease in pill form. One too many teaspoons of olive oil and you're in for an unpleasant evening...
  - ortusdux 3y ago
    I remember grabbing a pamphlet when it was new and reading their recommendation to wear dark colored pants and bring a change of clothes to work.
    - op00to 3y ago
      [flagged]
      - aidenn0 3y ago
        I want to frame this comment as an example of (the generalized form of) Poe's law.
        op00to 3y ago
        It’s better to not know.
    - znpy 3y ago
      Jesus Christ on a bike, that’s beyond dystopian, that’s completely f—-ked up. Does the fda allow that?
MandieD 3y ago
Your relative’s sad story reminds me of a short story I read a few years ago about a miracle pill that leaves about 90% of its takers perfectly slim and able to stay that way eating anything, after a few truly disgusting initial days of elimination, but kills the other 10% gruesomely. Because it’s so wonderfully effective for the majority, there ends up being a ton of social and economic pressure for anyone even slightly overweight to take it, despite said 10% risk of death. (Edited to add): “The Pill,” by Meg Elison https://escapepod.org/2022/11/03/escape-pod-861-the-pill-part-1-of-2/ https://escapepod.org/2022/11/03/escape-pod-861-the-pill-par... https://escapepod.org/2022/11/10/escape-pod-862-the-pill-part-2-of-2/ https://escapepod.org/2022/11/10/escape-pod-862-the-pill-par...
- Dan42 3y ago
  Thank you, thank you so much for sharing that. It's been a while since the last time my mind was blown away that much.
- hayst4ck 3y ago
  I have to admit, I would probably have taken the pill depending on how gruesome (or mitigatible) the death is. I've been obese and I've been thin, and life is not worth living when obese. 10 years ago, I was reading about nootropics and ran across an interesting piece on the ethics of drugs (that has probably been lost to time). The question it was asking was "why can we take drugs to bring us to normal, but we can't take drugs that make us better than normal?" The interesting consequence is that it de facto forces people who don't need drugs to take them or be at a disadvantage. (think adderall at a competitive college or testosterone for lifting).
  - grugagag 3y ago
    > The question it was asking was "why can we take drugs to bring us to normal, but we can't take drugs that make us better than normal?" Because ultimately drugs make you pay one way or another, eg dependency, liver toxicity, numbness of some other facet and so on. When none of those will be true it’s the day they become the new norm
ex3ndr 3y ago
Super weird since once you get thyroid problems, you have to drop this medication.
renewiltord 3y ago
[flagged]
- TeMPOraL 3y ago
  Not helpful. Drugs are drugs. Side effect happens. Sometimes not even related to the drug. I don't know how you folks do it in the US, but I imagine there is a leaflet attached to the medication, and somewhere in it should be a phone number, physical address and/or an e-mail address of an institution that tracks drug side effects. If you're unlucky enough to have some weird reaction to a drug, it's good to let them know.
- rafaelero 3y ago
  Right? For god sake folks, trust the randomized trials, not Internet nocebo screamers.
- dasfdslj 3y ago
  [flagged]
vrc 3y ago
The risk of pancreatitis is also increased substantially [0]. And for people who may already be predisposed to pancreatitis but haven’t had an attack, severe pancreatitis has a 10-30% mortality rate [1]. But even mild acute pancreatitis will make you want to crawl out of your own skin in pain. [0] https://www.hopkinsmedicine.org/news/media/releases/johns_hopkins_scientists_say_risk_of_pancreatitis_doubles_for_those_taking_new_class_of_diabetes_drugs_ https://www.hopkinsmedicine.org/news/media/releases/johns_ho... [1] https://www.aafp.org/pubs/afp/issues/2007/0515/p1513.html https://www.aafp.org/pubs/afp/issues/2007/0515/p1513.html
- mattzito 3y ago
  So I was able to find an aggregate of the study results: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294388/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294388/ out of an n of >3000 patients getting medication, 34 ended up having some form of pancreatitis. At least 12 people on placebo got pancreatitis. That's a much higher rate, but the odds are still pretty low.
- nullc 3y ago
  I'm somewhat dubious of the severe pancreatitis mortality rates-- the issue is that most cases of severe pancreatitis are caused by very severe alcoholism, and by the time the pancreatitis shows up everything else is already failing.
  - vrc 3y ago
    That’s not entirely true. Pancreatitis, especially necrotizing pancreatitis, actually causes the broad systemic organ dysfunction. So even alcoholics with fine organs can end up with liver, lung, heart, kidney, etc complications from a severe bout of pancreatitis. Even basic things like fluid balance and endocrine function can be thrown way off by both the disease and treatment (large amounts of fluid resuscitation). I recently had severe bouts of non-alcoholic pancreatitis, the worst of which ended in a 3 month hospital stay with various periods on ventilators and various organ dysfunction. My imaging and bloodwork from 3 weeks prior were clean (I do them routinely since the pancreatitis is recurring).
crazygringo 3y ago
Yeah, that's definitely always been my challenge with weight loss. I have zero problem with self control -- I can easily cut calories in half or less (e.g. 1000-1200 cal/day), but it's simply that my body suffers immensely. I lose all energy, can't concentrate on anything, and my immune system weakens so I start getting colds constantly. I'm sure I'd easily lose weight with Ozempic but I'd still be suffering health issues. Not because of Ozempic itself but just because I wouldn't be getting enough calories, despite still being above a healthy weight.
- skulk 3y ago
  > my body suffers immensely Does the same thing happen if you slowly wean yourself down? Are you cutting out essential nutrients that your body needs to function properly rather than the unnecessary carbs/junk? The reason I'm asking these things is that people I know who have reduced their caloric intake usually report feeling better, not worse.
- lumb63 3y ago
  You may have better success in a smaller caloric deficit. 1000-1200 calories a day is very few and that’s a very fast pace of weight loss. Try removing 500 calories or 10% of your calories. Progress will be slower, but you may feel much better. Also, as a sibling comment alluded to, when you have fewer calories to eat, the micronutrients in the few foods you do eat matter that much more. The nutritional quality of food you need to stay healthy increases greatly when in a caloric deficit. Fruits and veggies are great for helping that, and multivitamins are cheap insurance policies to make sure you aren’t deficient in anything important, IMO. YMMV. Best of luck with your goals!
- jjeaff 3y ago
  That reaction may have to do with too much cutting, as another commenter alluded to, but it may also have to do with the types of nutrients you are missing when cutting.
- kika 3y ago
  Calories are not created equal. They are equal in physics sense, but your body is not a "bomb calorimeter" (device to measure caloric content of whatever). So maybe instead of cutting your calories in half, you cut less and replace carb calories with fat calories or protein calories. Or maybe you can even cut to 1000-1200 by replacing your calorie source with something else. For some weird reason carrots with butter work very well for me and I love the taste :-)
smith7018 3y ago
I know someone that took it and his gallbladder burst. Doctors couldn’t say if it was related to the drug, though.
cameronh90 3y ago
As a counterpoint, I've been using it for several months and have had no side effects to speak of other than occasionally some mild reflux. If anything, my energy levels actually went up immediately after starting it. Normally I was pretty sluggish but it felt like some extra firepower was unlocked. Everything has risks and benefits, and might harm some people. I hope your family member gets better soon.
- mgarfias 3y ago
  I’ve been on it (at 1mg, then 2mg doses) for 3-4 years now. Worst side effect for me is the tendency to have sulfur smelling burps if I have any kind of stomach upset.
  - desmosxxx 3y ago
    did the weight stay off? Do you notice tolerance
    - mgarfias 3y ago
      Didn’t lose weight at 1mg. Down about 20# since the 2mg was approved. But, also doing CrossFit 3D/wk. and now have a CGM so I can easily track blood glucose.
  - runsWphotons 3y ago
    Second the question about tolerance! Wondering why this doesnt happen it is interesting. Most everything else causes some tolerance over time but no one mentions it for this
reaperman 3y ago
As a counter-counter-point I've read most (~90%) of the papers that come out of trials registered at http://clinicaltrials.gov/ http://clinicaltrials.gov/ for all GLP-1 agonists, including ones that haven't been approved. The vast, vast, vast majority of secondary outcomes, for things like - blood pressure - lipids (HDL, LDL) - insulin sensitivity - blood glucose - strokes - cardiovascular events + deaths - myocardial infarctions - hemoglobin A1C, - revascularization, - etc, etc, etc are literally all affected positively (to the benefit of the imaginary "mean" patient) in bulk. Note though, that doesn't mean 100% of patients are have positive results, just that each of these are, in bulk, positive across the tested subjects when averaged together. There's little in the data to suggest that cases like your family member aren't happening or couldn't happen. There's also evidence that GLP-1 agonists increase the rate of glucose use in the brain, accelerating learning rates. (The brain accounts for 2% of body weight but up to 25% of glucose consumption, it really is fueled by glucose) https://clinicaltrials.gov/ct2/show/NCT00256256?term=stroke&cond=glp-1&draw=2&rank=4 https://clinicaltrials.gov/ct2/show/NCT00256256?term=stroke&...
- atkailash 3y ago
  [dead]
ESTheComposer 3y ago
I started Wegovy about 5 months ago. The first couple months you feel sick but after it passes your appetite is extremely curbed (in a good way). Would highly recommend people to try it as it's made me healthier in pretty much every way.
- transcriptase 3y ago
  Bold move to name their pharmaceutical like a Chinese Amazon “brand” of AliExpress-sourced electronics.
SystemOut 3y ago
My story / anecdata. About 6 months ago there was a posting about Ozempic and I had said something to the effect that it wasn't worth it watching some of the side effects my wife had from it. And then I went to the doctor for a check-up and lo and behold I had diabetes. Asymptomatic, but an A1C of 11. My doctor re-ran the test because he didn't believe it and it doesn't run in my family. My cholesterol had also jumped and he said he was going to put me on a statin after the initial 3 months of adjusting to the diabetes medication. My Dr. puts me on Ozempic and I grumble about it but with that test results I had, I knew I had to do something. Fast forward 3 months, I dropped 20 pounds, and every other measurement is back in the green, including my A1C. Now, I made some serious lifestyle changes and ate a diabetic diet (limiting carbs, the types of carbs, etc), and have been keeping up with being more active but my entire relationship with food has changed because of Ozempic. Before I had a near compulsion to eat more than I should. Now, I don't because one, I feel fuller quicker and two, I know I'll feel horrible for hours if I over-eat. It only took one of those events to never want to do that again. I can't really explain why but I also don't have as strong of a desire to eat foods that are bad for me. I really thought I'd battle the cravings more after going cold turkey from "bad" foods. I can't say why it is but it's true. Side note, going to the grocery story was really difficult at first....there is so much sugar in the American food supply. Energy wise I will say that I did struggle with low energy initially as my body adapted to lower calorie intake but I also learned that when I found the right balance of protein/complex carbs for me that my energy levels came back up and I now feel better than ever. My doctor was shocked. I've never seen him that animated when I came back in for the 3 month follow-up. I didn't need to add any additional medications and they're slowly adjusting me back towards a single medication.
- justinclift 3y ago
  Out of curiosity, do you drink much water each day? I'm kind of wondering if the people having a bad result don't drink enough water each day to clear out their systems? Yeah, that's a simplistic take... but still, curiosity. :)
  - SystemOut 3y ago
    Yeah, most of the time I think I do. I suspect it has to do more with diet and maybe water as well. Since Ozempic slows down your digestive process my current thought is that fiber / gut bacteria might have more affect on things but I haven't done a food diary to try and track what impacts me more.
etchasketch 3y ago
I know this isn't your family member, but if they were a 500-pound alcoholic smoking two packs of cigarettes a day, I suspect they probably felt like crap before the ozempic.

by lumb63 3y ago

ikekkdcjkfke 3y ago

Same experience here, gallstone attacks

shrimp_emoji 3y ago
You can get those from rapid weight loss, I thought. Maybe it's working TOO well if that's the case.
- jjeaff 3y ago
  Ya, rapid weight loss is one of the most common triggers of gall stones. Lots of weight loss surgery patients get them as well.
  - winocm 3y ago
    Happened to me too from just generally not eating much at the time. Ended up getting acute cholecystitis and a dead gallbladder plus sepsis after. Not too pleasant of an experience.

burnte 3y ago

I take it, and when I started I got violently nauseous and had GI issues. I wasn't informed I needed to slowly ramp up. I still have pretty big appetite suppression, and only minimal nausea sometimes if I eat too much, but what it's done to my blood glucose is AMAZING. And I lost some weight when I started which was a great bonus. It can be hard to start but it's truly worth it, just adjust the dose. I take 0.5mg as I can't handle the larger 1.0mg dose.

reaperman 3y ago
> I wasn't informed I needed to slowly ramp up. In a fair world that would be considered severe malpractice :-( It's nearly common knowledge. A huge number of people are suffering under these medications because of starting at a dose to high or raising doses too quickly / too much at a time. LY3437943 looks even more promising, with fewer side effects. Semaglutide will probably have the most side effects because it only has one action (GLP-1 agonist). Tirzepatide has slightly lower side effects because it adds a dual action (GLP-1 agonist + GIP analogue) so it can act at a lower magnitude on the GLP-1 receptors to avoid strong side effects, while still having higher efficacy due to its additional, separate, GIP action. LY3437943 retains both the actions of Tirzepatide but adds a third action, glucagon receptor agonist. So it should be able to have higher efficacy at a lower equivalent dose than the other two (less action on GLP-1 and GIP mechanisms, fewer side effects).

kristofferR 3y ago

While others have none or barely any side effects, it is a drug after all. For those people who tolerate the drug well, it can be revolutionary in their lives, but it's unfortunately not a good fit for everyone. I hope your family member gets better soon.

ortusdux 3y ago

>>due to the fact that eating now makes her sick. Reminds me of the first FDA approved weight loss drug, Alli, that basically just gastrointestinally punishes you if you eat more than a few grams of fat. https://en.wikipedia.org/wiki/Orlistat#Side_effects https://en.wikipedia.org/wiki/Orlistat#Side_effects

spondylosaurus 3y ago
> The manual for Alli makes it clear that orlistat treatment involves aversion therapy, encouraging the user to associate eating fat with unpleasant treatment effects. Christ. This is like Crohn's disease in pill form. One too many teaspoons of olive oil and you're in for an unpleasant evening...
- ortusdux 3y ago
  I remember grabbing a pamphlet when it was new and reading their recommendation to wear dark colored pants and bring a change of clothes to work.
  - op00to 3y ago
    [flagged]
    - aidenn0 3y ago
      I want to frame this comment as an example of (the generalized form of) Poe's law.
      - op00to 3y ago
        It’s better to not know.
  - znpy 3y ago
    Jesus Christ on a bike, that’s beyond dystopian, that’s completely f—-ked up. Does the fda allow that?

MandieD 3y ago

Your relative’s sad story reminds me of a short story I read a few years ago about a miracle pill that leaves about 90% of its takers perfectly slim and able to stay that way eating anything, after a few truly disgusting initial days of elimination, but kills the other 10% gruesomely. Because it’s so wonderfully effective for the majority, there ends up being a ton of social and economic pressure for anyone even slightly overweight to take it, despite said 10% risk of death. (Edited to add): “The Pill,” by Meg Elison https://escapepod.org/2022/11/03/escape-pod-861-the-pill-part-1-of-2/ https://escapepod.org/2022/11/03/escape-pod-861-the-pill-par... https://escapepod.org/2022/11/10/escape-pod-862-the-pill-part-2-of-2/ https://escapepod.org/2022/11/10/escape-pod-862-the-pill-par...

Dan42 3y ago
Thank you, thank you so much for sharing that. It's been a while since the last time my mind was blown away that much.
hayst4ck 3y ago
I have to admit, I would probably have taken the pill depending on how gruesome (or mitigatible) the death is. I've been obese and I've been thin, and life is not worth living when obese. 10 years ago, I was reading about nootropics and ran across an interesting piece on the ethics of drugs (that has probably been lost to time). The question it was asking was "why can we take drugs to bring us to normal, but we can't take drugs that make us better than normal?" The interesting consequence is that it de facto forces people who don't need drugs to take them or be at a disadvantage. (think adderall at a competitive college or testosterone for lifting).
- grugagag 3y ago
  > The question it was asking was "why can we take drugs to bring us to normal, but we can't take drugs that make us better than normal?" Because ultimately drugs make you pay one way or another, eg dependency, liver toxicity, numbness of some other facet and so on. When none of those will be true it’s the day they become the new norm

ex3ndr 3y ago

Super weird since once you get thyroid problems, you have to drop this medication.

renewiltord 3y ago

[flagged]

TeMPOraL 3y ago
Not helpful. Drugs are drugs. Side effect happens. Sometimes not even related to the drug. I don't know how you folks do it in the US, but I imagine there is a leaflet attached to the medication, and somewhere in it should be a phone number, physical address and/or an e-mail address of an institution that tracks drug side effects. If you're unlucky enough to have some weird reaction to a drug, it's good to let them know.
rafaelero 3y ago
Right? For god sake folks, trust the randomized trials, not Internet nocebo screamers.
dasfdslj 3y ago
[flagged]

vrc 3y ago

The risk of pancreatitis is also increased substantially [0]. And for people who may already be predisposed to pancreatitis but haven’t had an attack, severe pancreatitis has a 10-30% mortality rate [1]. But even mild acute pancreatitis will make you want to crawl out of your own skin in pain. [0] https://www.hopkinsmedicine.org/news/media/releases/johns_hopkins_scientists_say_risk_of_pancreatitis_doubles_for_those_taking_new_class_of_diabetes_drugs_ https://www.hopkinsmedicine.org/news/media/releases/johns_ho... [1] https://www.aafp.org/pubs/afp/issues/2007/0515/p1513.html https://www.aafp.org/pubs/afp/issues/2007/0515/p1513.html

mattzito 3y ago
So I was able to find an aggregate of the study results: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294388/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294388/ out of an n of >3000 patients getting medication, 34 ended up having some form of pancreatitis. At least 12 people on placebo got pancreatitis. That's a much higher rate, but the odds are still pretty low.
nullc 3y ago
I'm somewhat dubious of the severe pancreatitis mortality rates-- the issue is that most cases of severe pancreatitis are caused by very severe alcoholism, and by the time the pancreatitis shows up everything else is already failing.
- vrc 3y ago
  That’s not entirely true. Pancreatitis, especially necrotizing pancreatitis, actually causes the broad systemic organ dysfunction. So even alcoholics with fine organs can end up with liver, lung, heart, kidney, etc complications from a severe bout of pancreatitis. Even basic things like fluid balance and endocrine function can be thrown way off by both the disease and treatment (large amounts of fluid resuscitation). I recently had severe bouts of non-alcoholic pancreatitis, the worst of which ended in a 3 month hospital stay with various periods on ventilators and various organ dysfunction. My imaging and bloodwork from 3 weeks prior were clean (I do them routinely since the pancreatitis is recurring).

crazygringo 3y ago

Yeah, that's definitely always been my challenge with weight loss. I have zero problem with self control -- I can easily cut calories in half or less (e.g. 1000-1200 cal/day), but it's simply that my body suffers immensely. I lose all energy, can't concentrate on anything, and my immune system weakens so I start getting colds constantly. I'm sure I'd easily lose weight with Ozempic but I'd still be suffering health issues. Not because of Ozempic itself but just because I wouldn't be getting enough calories, despite still being above a healthy weight.

skulk 3y ago
> my body suffers immensely Does the same thing happen if you slowly wean yourself down? Are you cutting out essential nutrients that your body needs to function properly rather than the unnecessary carbs/junk? The reason I'm asking these things is that people I know who have reduced their caloric intake usually report feeling better, not worse.
lumb63 3y ago
You may have better success in a smaller caloric deficit. 1000-1200 calories a day is very few and that’s a very fast pace of weight loss. Try removing 500 calories or 10% of your calories. Progress will be slower, but you may feel much better. Also, as a sibling comment alluded to, when you have fewer calories to eat, the micronutrients in the few foods you do eat matter that much more. The nutritional quality of food you need to stay healthy increases greatly when in a caloric deficit. Fruits and veggies are great for helping that, and multivitamins are cheap insurance policies to make sure you aren’t deficient in anything important, IMO. YMMV. Best of luck with your goals!
jjeaff 3y ago
That reaction may have to do with too much cutting, as another commenter alluded to, but it may also have to do with the types of nutrients you are missing when cutting.
kika 3y ago
Calories are not created equal. They are equal in physics sense, but your body is not a "bomb calorimeter" (device to measure caloric content of whatever). So maybe instead of cutting your calories in half, you cut less and replace carb calories with fat calories or protein calories. Or maybe you can even cut to 1000-1200 by replacing your calorie source with something else. For some weird reason carrots with butter work very well for me and I love the taste :-)

smith7018 3y ago

I know someone that took it and his gallbladder burst. Doctors couldn’t say if it was related to the drug, though.

cameronh90 3y ago

As a counterpoint, I've been using it for several months and have had no side effects to speak of other than occasionally some mild reflux. If anything, my energy levels actually went up immediately after starting it. Normally I was pretty sluggish but it felt like some extra firepower was unlocked. Everything has risks and benefits, and might harm some people. I hope your family member gets better soon.

mgarfias 3y ago
I’ve been on it (at 1mg, then 2mg doses) for 3-4 years now. Worst side effect for me is the tendency to have sulfur smelling burps if I have any kind of stomach upset.
- desmosxxx 3y ago
  did the weight stay off? Do you notice tolerance
  - mgarfias 3y ago
    Didn’t lose weight at 1mg. Down about 20# since the 2mg was approved. But, also doing CrossFit 3D/wk. and now have a CGM so I can easily track blood glucose.
- runsWphotons 3y ago
  Second the question about tolerance! Wondering why this doesnt happen it is interesting. Most everything else causes some tolerance over time but no one mentions it for this

reaperman 3y ago

As a counter-counter-point I've read most (~90%) of the papers that come out of trials registered at http://clinicaltrials.gov/ http://clinicaltrials.gov/ for all GLP-1 agonists, including ones that haven't been approved. The vast, vast, vast majority of secondary outcomes, for things like - blood pressure - lipids (HDL, LDL) - insulin sensitivity - blood glucose - strokes - cardiovascular events + deaths - myocardial infarctions - hemoglobin A1C, - revascularization, - etc, etc, etc are literally all affected positively (to the benefit of the imaginary "mean" patient) in bulk. Note though, that doesn't mean 100% of patients are have positive results, just that each of these are, in bulk, positive across the tested subjects when averaged together. There's little in the data to suggest that cases like your family member aren't happening or couldn't happen. There's also evidence that GLP-1 agonists increase the rate of glucose use in the brain, accelerating learning rates. (The brain accounts for 2% of body weight but up to 25% of glucose consumption, it really is fueled by glucose) https://clinicaltrials.gov/ct2/show/NCT00256256?term=stroke&cond=glp-1&draw=2&rank=4 https://clinicaltrials.gov/ct2/show/NCT00256256?term=stroke&...

atkailash 3y ago
[dead]

ESTheComposer 3y ago

I started Wegovy about 5 months ago. The first couple months you feel sick but after it passes your appetite is extremely curbed (in a good way). Would highly recommend people to try it as it's made me healthier in pretty much every way.

transcriptase 3y ago
Bold move to name their pharmaceutical like a Chinese Amazon “brand” of AliExpress-sourced electronics.

SystemOut 3y ago

My story / anecdata. About 6 months ago there was a posting about Ozempic and I had said something to the effect that it wasn't worth it watching some of the side effects my wife had from it. And then I went to the doctor for a check-up and lo and behold I had diabetes. Asymptomatic, but an A1C of 11. My doctor re-ran the test because he didn't believe it and it doesn't run in my family. My cholesterol had also jumped and he said he was going to put me on a statin after the initial 3 months of adjusting to the diabetes medication. My Dr. puts me on Ozempic and I grumble about it but with that test results I had, I knew I had to do something. Fast forward 3 months, I dropped 20 pounds, and every other measurement is back in the green, including my A1C. Now, I made some serious lifestyle changes and ate a diabetic diet (limiting carbs, the types of carbs, etc), and have been keeping up with being more active but my entire relationship with food has changed because of Ozempic. Before I had a near compulsion to eat more than I should. Now, I don't because one, I feel fuller quicker and two, I know I'll feel horrible for hours if I over-eat. It only took one of those events to never want to do that again. I can't really explain why but I also don't have as strong of a desire to eat foods that are bad for me. I really thought I'd battle the cravings more after going cold turkey from "bad" foods. I can't say why it is but it's true. Side note, going to the grocery story was really difficult at first....there is so much sugar in the American food supply. Energy wise I will say that I did struggle with low energy initially as my body adapted to lower calorie intake but I also learned that when I found the right balance of protein/complex carbs for me that my energy levels came back up and I now feel better than ever. My doctor was shocked. I've never seen him that animated when I came back in for the 3 month follow-up. I didn't need to add any additional medications and they're slowly adjusting me back towards a single medication.

justinclift 3y ago
Out of curiosity, do you drink much water each day? I'm kind of wondering if the people having a bad result don't drink enough water each day to clear out their systems? Yeah, that's a simplistic take... but still, curiosity. :)
- SystemOut 3y ago
  Yeah, most of the time I think I do. I suspect it has to do more with diet and maybe water as well. Since Ozempic slows down your digestive process my current thought is that fiber / gut bacteria might have more affect on things but I haven't done a food diary to try and track what impacts me more.

etchasketch 3y ago

I know this isn't your family member, but if they were a 500-pound alcoholic smoking two packs of cigarettes a day, I suspect they probably felt like crap before the ozempic.