7 ms·

This is coming from David Sinclair, who claimed resveratrol was the fountain of youth (it wasn't, but he still managed to sell his resveratrol company for hundr

by jkarni 4y ago

This is coming from David Sinclair, who claimed resveratrol was the fountain of youth (it wasn't, but he still managed to sell his resveratrol company for hundreds of millions), and pushed rather hard also on NAD/NMN despite only very preliminary and limited results (he also has interests in NMN companies, and has been involved in removing it from the supplement market in favor of that company's right to market it as a drug). More likely than a cure for aging, Sinclair just found another cure for too few cars in his garage. https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-a-mouse/ https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-... https://www.nutraingredients-usa.com/Article/2022/11/15/FDA-s-takedown-of-NMN-raises-fairness-transparency-concerns https://www.nutraingredients-usa.com/Article/2022/11/15/FDA-...

jjallen 4y ago
He also says this in the article: “ This is the first study showing that we can have precise control of the biological age of a complex animal; that we can drive it forwards and backwards at will” And the paper doesn’t show that at all. The paper does not show them reversing the aging of anything.
- generalizations 4y ago
  I couldn't get access to the paper, but the abstract and the article both claimed they were able to reverse organ damage caused by the aging. Is that not backed up in the paper?
ShredKazoo 4y ago
Who in the anti-aging space do HN users consider credible?
- robwwilliams 4y ago
  Without any doubt—The NIA Interventions Testing Program. They have 20 years of experience on effects of dietary interventions supporting longer lifespan. https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/about-itp https://www.nia.nih.gov/research/dab/interventions-testing-p...
  - trinsic2 4y ago
    Does anybody write articles on the stuff that is released from this org that lay people can understand?
    - sinenomine 4y ago
      There is Reason who runs a successful biotech company, and his corpus of writing at https://fightaging.org https://fightaging.org His commentary on new papers in ageing is pretty good, in my opinion. He has a good coverage of NIA ITP trials as well: https://duckduckgo.com/?q=site%3Afightaging.org+NIA&ia=web https://duckduckgo.com/?q=site%3Afightaging.org+NIA&ia=web
- jjallen 4y ago
  Dr. Kaeberlein and Dr. Attia.
kaczordon 4y ago
Idk why selling something you believe in disqualifies you as a scientist. He’s also helped pioneer and make credible the entire field of aging research to reform people’s idea of how to look at aging. Don’t be so cynical dude.
- nradov 4y ago
  It's generally still not considered a credible field. Mostly hucksters and grifters.
k2xl 4y ago
He is a professor at Harvard - I imagine he wouldn't get to that role if the science didn't have some merit. Where did he ever say that resveratol was the fountain of youth? Interviews I've seen with him seem more reasonable then I always hear people make him out to be. NMN does have some promising results based on recent studies- what do you mean he pushed hard? Where did he actually do that?
- jkarni 4y ago
  Resveratrol is "as close to a miraculous molecule as you can find." NAD+ “is the closest we’ve gotten to a fountain of youth.” Both quoted in an excellent article on Sinclair: https://www.bostonmagazine.com/health/2019/10/29/david-sinclair/ https://www.bostonmagazine.com/health/2019/10/29/david-sincl...
- icelancer 4y ago
  >> He is a professor at Harvard - I imagine he wouldn't get to that role if the science didn't have some merit. You should see what Huberman often shills and he's a prestigious professor as well. Would also add that until recently - and by his own hand - Jordan Peterson was a professor at first Harvard, then the University of Toronto.
  - gmadsen 4y ago
    what exactly does Huberman shill? As far as I can tell, he has done an extemely commendable service bringing academic literature to the masses.
  - elektrontamer 4y ago
    Don't know about Huberman but how did JP "shill" anything? Can you give a few examples of deceptive statements by him?
    - worik 4y ago
      > Can you give a few examples of deceptive statements by him? Joking, are we?

by jkarni 4y ago

jjallen 4y ago

He also says this in the article: “ This is the first study showing that we can have precise control of the biological age of a complex animal; that we can drive it forwards and backwards at will” And the paper doesn’t show that at all. The paper does not show them reversing the aging of anything.

generalizations 4y ago
I couldn't get access to the paper, but the abstract and the article both claimed they were able to reverse organ damage caused by the aging. Is that not backed up in the paper?

ShredKazoo 4y ago

Who in the anti-aging space do HN users consider credible?

robwwilliams 4y ago
Without any doubt—The NIA Interventions Testing Program. They have 20 years of experience on effects of dietary interventions supporting longer lifespan. https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/about-itp https://www.nia.nih.gov/research/dab/interventions-testing-p...
- trinsic2 4y ago
  Does anybody write articles on the stuff that is released from this org that lay people can understand?
  - sinenomine 4y ago
    There is Reason who runs a successful biotech company, and his corpus of writing at https://fightaging.org https://fightaging.org His commentary on new papers in ageing is pretty good, in my opinion. He has a good coverage of NIA ITP trials as well: https://duckduckgo.com/?q=site%3Afightaging.org+NIA&ia=web https://duckduckgo.com/?q=site%3Afightaging.org+NIA&ia=web
jjallen 4y ago
Dr. Kaeberlein and Dr. Attia.

kaczordon 4y ago

Idk why selling something you believe in disqualifies you as a scientist. He’s also helped pioneer and make credible the entire field of aging research to reform people’s idea of how to look at aging. Don’t be so cynical dude.

nradov 4y ago
It's generally still not considered a credible field. Mostly hucksters and grifters.

k2xl 4y ago

He is a professor at Harvard - I imagine he wouldn't get to that role if the science didn't have some merit. Where did he ever say that resveratol was the fountain of youth? Interviews I've seen with him seem more reasonable then I always hear people make him out to be. NMN does have some promising results based on recent studies- what do you mean he pushed hard? Where did he actually do that?

jkarni 4y ago
Resveratrol is "as close to a miraculous molecule as you can find." NAD+ “is the closest we’ve gotten to a fountain of youth.” Both quoted in an excellent article on Sinclair: https://www.bostonmagazine.com/health/2019/10/29/david-sinclair/ https://www.bostonmagazine.com/health/2019/10/29/david-sincl...
icelancer 4y ago
>> He is a professor at Harvard - I imagine he wouldn't get to that role if the science didn't have some merit. You should see what Huberman often shills and he's a prestigious professor as well. Would also add that until recently - and by his own hand - Jordan Peterson was a professor at first Harvard, then the University of Toronto.
- gmadsen 4y ago
  what exactly does Huberman shill? As far as I can tell, he has done an extemely commendable service bringing academic literature to the masses.
- elektrontamer 4y ago
  Don't know about Huberman but how did JP "shill" anything? Can you give a few examples of deceptive statements by him?
  - worik 4y ago
    > Can you give a few examples of deceptive statements by him? Joking, are we?