12 ms·
Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy
- mod 4y agoThere was an in depth discussion about this drug with a longevity researcher on a recent episode of the Tim Ferriss podcast, in case anyone wants to dive deeper.
- sndean 4y ago> a longevity researcher Probably Peter Attia? There's also some free to read review articles (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/). No idea about the quality of the journal Aging or the field in general, though.
- mod 4y agoNo, Matt Kaeberlein-- here's the transcript of the episode. https://tim.blog/2022/07/30/matt-kaeberlein-life-extension-transcript/ https://tim.blog/2022/07/30/matt-kaeberlein-life-extension-t...
- theplumber 4y agoThis part sounds familiar: "One step closer to applications"
- jjallen 4y agoI know and agree with this sentiment. However, you can take Rapamycin now. It is an existing drug.
- w10-1 4y ago"you can take Rapamycin now. It is an existing drug" No: your doctor can prescribe it for you if it's indicated, or when there's good evidence that you need what it can do more than the side effects you'll suffer. It's just like a gun: useful in some situations. But unlike guns, it's not you who decides.
- orangepurple 4y agoThe bigger story with rapamycin is that the mechanistic target of rapamycin (mTOR) plays an absolutely crucial role in major diseases of modern civilization. One of the ways to inhibit mTOR for free is to simply stop consuming nutrients for extended periods of time.
- Tepix 4y ago> ... to simply stop consuming nutrients for extended periods of time That is not simple for most people.
- chrisweekly 4y agosimple != easy
- orangepurple 4y agoAgree; it was very painful initially and not easy. But very simple conceptually!
- MisterTea 4y agoI did caloric restriction for a year and eased into it gradually until I was eating two small meals a day. I had no ailments but weighed upward of 230 lbs, 104kg. In a year I went down to near zero body fat and weighed 150lbs/68kg. Unfortunately for my build and frame that made me look sickly so I started eating again and Ive settled around 165 and working to put on a little muscle. Overall I'd say I did this whole thing over two years without much effort. Though yes, getting over the hunger pangs is very hard but once over them you quickly learn to ignore them.
- cbozeman 4y agoSupplementing with potassium, magnesium, and sodium can help alleviate the hunger pangs I've found.
- 4y ago
- meremortals 4y agoHow does one find a doctor willing to prescribe these kinds of drugs for anti aging?
- aaaaaaaaaaab 4y agoPool your money with others and order in bulk from Asian or Sourh American suppliers. No questions asked. There are specific subreddits/forums for this kind of stuff.
- jmhyer123 4y agoCould you point me to some of those subreddits/forums? A quick search didn't yield anything but I'm probably not familiar with the specific terminology they would use.
- nik_s 4y agoYou can order these drugs in bulk from chemical vendors for research purposes (i.e. non-human use). Chemscene, to name just one, sells Rapamacyn at 1440 USD for 5g. EDIT: I clearly don't recommend you buying this and taking it by the way. You're never quite sure about the purity nor about how to dose this effectively as a layperson without access to a lab. It's also possibly completely illegal, depending on your local laws.
- LorenPechtel 4y agoYeah. By the time you're looking at stuff in the milligram range it becomes quite problematic to ensure consistent doses. I would be confident that I could get an *average* of 1mg/day but I would not be confident I could ensure every day was in .9mg to 1.1mg.
- orangepurple 4y agoThe easiest way by safely and strongly inhibit mTOR is to simply stop eating for a while. Most people don't need the drug.
- 4y ago
- swayvil 4y agoWhat's the latest on bloodboys? That is : periodic blood transfusion from healthy young vegan donor. It works very well. Rejuvenates ancient billionaires. Surely it's superpopular among the oligarchs. Probably not the kind of thing you want in the news (vampires!). The technical term is Parabiosis. These guys offer the service : https://www.ambrosiaplasma.com/ https://www.ambrosiaplasma.com/
- isoprophlex 4y agoEvery day we stray further from god's light
- chimen 4y ago[1] - "The figures are staggering: out of 35,000 children in care, more than 2,000 were physically or sexually abused by priests between 1936 and 1999" (Ireland alone) [2] - French Church abuse: 216,000 children were victims of clergy - inquiry 1. https://www.justiceinfo.net/en/45133-sexual-abuse-church-map-justice-worldwide.html https://www.justiceinfo.net/en/45133-sexual-abuse-church-map... 2. https://www.bbc.com/news/world-europe-58801183 https://www.bbc.com/news/world-europe-58801183
- atdrummond 4y agoI saw no indication he was promoting the Church, rather than belief in G-d. (Not that it was a relevant reply anyway.)
- telesilla 4y agoThe article states effectiveness requires taking the drug as a young adult, precisely the time most people are not thinking about mortality.
- lbotos 4y agoI’d beg to differ. In the modern social media age youths are getting a lot more vain. Teen boys are doing skincare routines. So historically, I’d agree, but now that everyone can be a minor celeb in their own circle I think the youth are more focused on aging.
- noneeeed 4y ago> Teen boys are doing skincare routines. For context, there have been other periods in history when young men were as focused on their apperance as women, used makeup and obsessed about how they were seen. Social media gives an outlet for this to those who are not wealthy, but none of it is fundamentally new, it was just confined to those who were able to do it.
- yamtaddle 4y ago> Teen boys are doing skincare routines. Maybe, but I'd be careful about generalizing that kind of thing. Even stuff like consistently applying sunscreen is heavily dependent on class membership, i.e. it's "just what you do, obviously, any time you're going to be outside at all, of course we always have sunscreen on-hand and our kids have been taught to apply it as routinely and consistently as tooth-brushing—wait, why are you asking, doesn't everyone do that?" in some circles, while in other (larger) circles they only break it out for beach or lake days, if at all. I expect the described behavior is similarly unevenly distributed.
- junon 4y agoI'm not even 30 yet and I'm already thinking about my mortality.
- boredemployee 4y agogenuine question: why would someone want to live longer than the average? Edit: I ask because I personally don't see a reason to stay alive while people I love are dying, I don't see a reason to stay alive in an already fucked up planet, while we empty all the resources, etc. But you guys are so smart, intelligent and clever, why even bother.
- CalRobert 4y agoMore time to do the things you enjoy.
- sph 4y agoMore time to be a productive member of society, you mean.
- ryeights 4y agoWho wouldn’t want to be healthier than average at a given age?
- wolfram74 4y agoCuriosity? See where this ride is going and maybe have some hand however small to steer it?
- deeel 4y agoIt's not only "living longer" as a whole organism, but also your individual organs living longer (that ultimately impact aging). Take ovaries for example: Menopause causes major health problems (osteoporosis, cardiovascular disease, etc) for women and women now spend on average more time post-menopause than pre. There's a good writeup about this problem and the companies researching it here: https://spannr.com/articles/oviva-therapeutics-raises-11-5m-to-solve-ovarian-aging https://spannr.com/articles/oviva-therapeutics-raises-11-5m-...
- boredemployee 4y agothat's a nice catch, thanks!
- CalRobert 4y agothe gist of it """ The scientists have tested different time windows of short-term drug administration in fruit flies and found that a brief window of 2 weeks of rapamycin treatment in young, adult flies protected them against age-related pathology in the intestine and extended their lives. A corresponding short time window, 3 months of treatment starting at 3 months of age in young, adult mice, had similar beneficial effects on the health of the intestine when they were middle-aged. “These brief drug treatments in early adulthood produced just as strong protection as continuous treatment started at the same time. We also found that the rapamycin treatment had the strongest and best effects when given in early life as compared to middle age. When the flies were treated with rapamycin in late life, on the other hand, it had no effects at all. So, the rapamycin memory is activated primarily in early adulthood”, explains Dr. Thomas Leech, co-author of the paper. """ And here I am wondering what the cutoff is for middle age...
- deleted 4y ago[deleted]
- dsign 4y agoWhen somebody asks about what is the next big thing, I always think on anti-aging. If you think that you don’t want to live forever, imagine that today when you arrive home you find a note saying that you will die exactly 1531[^1] days from today. How would you feel? With that said, I would stay away from miracle drugs, because no two human beings have the same physiology. But that’s not an unsolvable problem. [^1]: It’s a random number to “erase hope”. Not knowing when we are going to die keep us slightly hopeful and perky, our mind away from the problem.
- abcc8 4y agoI would argue that a miracle anti aging drug would work well for the majority of the population, much like NSAIDs work well for the majority of the population. Bonus points for being cheap and easy to synthesize.
- lijogdfljk 4y agoHonestly, at peace lol. I don't really care about living. My primary desire for living atm is keeping my family safe, providing for them, etc. Beyond that, i am living just because i am - and i enjoy life as much as i don't want to _not_ enjoy time i'm here anyway.
- rr888 4y agoI agree. But would be interested in staying younger/stronger/healthier for the same lifespan.
- fatuna 4y agoI think this is a great example of "what's good for the individual, is bad for humanity as a whole". Imagine we'd discovered a drug that adds 100 years to a persons natural life. Now imagine this drug was discovered 100 years ago. J.D. Rockefeller and the likes would still be alive and influencing politics. I can't even begin to think how much humanity would stagnate after such an invention. See also the Planck principle: "A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die and a new generation grows up that is familiar with it" https://en.wikipedia.org/wiki/Planck%27s_principle https://en.wikipedia.org/wiki/Planck%27s_principle
- criddell 4y agoIf you sign your dog up for the Dog Aging Project[1], you can get rapamycin for your dog. [1]: https://dogagingproject.org/ https://dogagingproject.org/
- ilaksh 4y agoThe idea that you could just take a pill one time and be "protected from aging" or something sounds ludicrous. Would be interested to see people reproduce these results and have them supposedly transfer over to humans. Humans are a much longer time scale. I always go back to the SENS concept of having several different problems to solve related to built up damage, cells that won't die, etc.
- sdenton4 4y agoIt's definitely not a one-time thing... There's a fascinating Radiolab episode on the the history of Rapomycin, including discussions of the mechanism of action: https://radiolab.org/episodes/dirty-drug-and-ice-cream-tub https://radiolab.org/episodes/dirty-drug-and-ice-cream-tub The basic hypothesis is that cells operate in two modes, one storing up stuff in times of plenty, and a second mode which uses up the stores and cleans up, active during lean times. mTor is supposed to be the chemical signal which indicates which mode to act in; it's inhibited by both fasting and rapomycin.
- Teever 4y agoPeople used to feel the same way about vaccines. Now we have vaccines that eliminate a specific form of cancer. Perhaps we will find a way to pack all the different treatments for the various SENS forms of aging into a single one-time pill. Maybe it will just be self-replicating nanobots. What a fascinating time we live in where we can actually start to make educated guesses about the viability and timeframe for these kinds of things.
- hericium 4y agoThis isn't new. David Sinclair wrote about rapamycin in Lifespan[1][2] (I keep linking this book on HN a lot; no relation) [1] https://en.wikipedia.org/wiki/Lifespan_(book) https://en.wikipedia.org/wiki/Lifespan_(book) [2] https://lifespanbook.com/ https://lifespanbook.com/
- shuntress 4y agoAnything David Sinclair has endorsed should be considered with at least double the normal skeptical scrutiny.
- dennis_jeeves1 4y agoLol, why do say that? I had the same impression of him. It appears that people fall for his niceness is my theory about him. And no doubt he is a nice guy. It's just that his explanations lacked the rigor I generally look for.
- emit_time 4y agoA lot of his earlier work with resveratrol was extremely sloppy and it fell apart in time. I believe it's a lot of what gained him earlier popularity, and has effectively been debunked to a very large degree.
- hericium 4y agoI don't think he _endorsed_ rapamycin or metformin. If he endorsed anything, I'd say it was NMN. Everything people like Sinclair state should be taken with a grain of salt (as even his peers say he's guilty of making excessive claims) but it's forward-thinkers who change the world, not people following others' steps and afraid to take peek outside their box. Maybe the guy will achieve something real in the field and maybe it'll be the next guy. No way to know. But I'm far from dismissing someone just because their opinions are not in line with popular knowledge. Boltzmann, Galileo, Copernicus and Wright brothers were discredited or ridiculed.
- nradov 4y agoDr. Peter Attia did a thorough summary several months ago of what we know about rapamycin as an anti-aging therapy. There are plausible reasons to think it might be safe and effective, but human studies are lacking. This is a promising area for future research. https://peterattiamd.com/ama35/ https://peterattiamd.com/ama35/
- derbOac 4y agoMaybe I missed this, but 2 weeks in fruit flies and 3 months in mice probably translates into something much longer in humans, on the order of a year or two maybe, if not longer? That's a pretty long time to be on an immune-suppressing drug with pretty significant side effects. It's still an important bit of information if it replicates, but I think it might not be as clinically practical as it sounds from the press release.
- pstuart 4y agoNot just the quantity of extended time, but the quality of that time matters too. Even if life wasn't extended a day but one had greater vigor/vitality/cognition it would still likely be a worthy pursuit.
- adamgordonbell 4y agoAnyone taking or have taken Rapamycin or things that change mTor? How did that go? Is there risk of infections? David Sinclair got me interested in this topic. Also people who fast for a long time: How do you do that? I get super hangry and find it really a struggle past a certain point of not eating.
- colechristensen 4y agoThe super unpleasant part of fasting is a phase that ends.
- kubami 4y agoI fast a lot, right now I do 36 - 72h every 6 - 8 weeks. The hardest moment is right when your body is about to switch from using glucose to using ketone bodies for energy. After that the hunger, feeling anxious, etc stops. The time it takes to get to that point (when feeling "bad" intensifies) and how long the transition takes can be influenced. Primarily, by what you eat before you fast. In general, avoid eating carbohydrates, especially simple carbohydrates like sugar, fruits, past, bread, etc. I usually eat more protein and fat before fasting. Another "trick" during fasting is to cheat your stomach a bit by filling it with liquids - I drink lots of water and tea. The main thing to remember - it will pass, and you will feel great after your body switches. Your mind will tell you that it will just progressively get worse the deeper you get into the fast - it's not true :)
- yazaddaruvala 4y agoOh I forgot about the tricks. Thanks. I also use the tricks mentioned above. They are very useful. Additional tricks: - Use fiber supplements in your water sometime in the middle of your fast (simplest time is in the morning in lieu of breakfast). I use psyllium husk. - Soup (or rather broth) is a fasting bff. Remember miso, herbs, spices, salt, do not have calories. Flavor your water liberally. Change up the consistency with stuff in it (green onions, seaweed). Change up the temperature (hot, cold, whatever). I even add psyllium husk to my soups to change up the texture and consistency just for the variety. Remember you can “eat” a lot of tasty stuff while still technically fasting. - Actively (rather than passively) deplete your glycogen stores. Do a workout ideally including cardio, then do your best to immediately fall asleep to recover. I can sleep through anything, if you can too you’ll be in keto by the morning and no real feelings of difficulty. - Remember to take a multi-vitamin daily while fasting. Make sure it doesn’t have sugar like those “vitamin C hangover powders” or “electrolyte water stuff like Gatorade”.
- ve55 4y agoI have been taking rapamycin for many years now. It's obviously not ready for anywhere near the general public and is never something I'd suggest to someone at this point, but my own results have been wonderful and my blood panels and energy levels are great. If I had to guess, when properly used, this would probably add a full 5-10 years onto the lifespan of a lot of people. When combined with many other promising treatments, I think we could easily add 10-15 years onto most peoples' health+lifespans.
- jesuscript 4y agoHow do you get it?
- ve55 4y agomost people either find a rare doctor that will prescribe it to you or purchase it without a subscription online
- jesuscript 4y agoWhat area are these rare doctors lol. Anti aging ain’t no joke, hook us up bro.
- ve55 4y agodon't know anyone personally taking new patients atm
- jesuscript 4y agoWhat a drug, huh?
- bigmattystyles 4y agoHopefully they mean aging remedy not anti-aging remedy...
- evo_9 4y agoI'm a month into taking rapa and already I feel like it's having a noticeable effect. I'm curious what others on this threads dosage looks like. If you prefer to keep it private, you can email me directly (my email is on my profile). I'm currently taking 2mg once a week on my rest day; I started with 1mg and after 1 month added another MG. I'll continue each month until I reach 8MG once a week, which is the dosage the doc I worked with in Texas to get my prescription recommended and most people seem to take. Also - I would say that NMN + Rapa is a completely life altering combination for anyone 50+. I feel like I can lift harder and longer now than when I was in my 40's and things seem to be getting easier the farther into my rapa routine I get. Also also - you can find rapamycin online / overseas under its other name - Sirolimus - and the cost is a little lower than getting a proper US prescription.
- pstuart 4y agoFinding a doctor who's up to "non-traditional" support can be a challenge, but you've inspired me to start that search.
- Traubenfuchs 4y agoBesides satisfying their altruism they have nothing to gain and everything to lose if this miracle drug causes cancer in 5 years. I read up ok it. It can literally cause cancer.
- SkyMarshal 4y agoWhich one, NMN or Rapa?
- cbozeman 4y agoDepending on where you are, everything can cause cancer. This website is known to the State of California to cause cancer.
- jaggederest 4y agoOne of the additives I work with in pottery is labeled with a prop 65 warning. The only ingredient is silicon dioxide, aka sand.
- rdedev 4y agoAfter reading the following article I've tempered my expectations from ramapycin https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-a-mouse/ https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-... The drug has been known for a long time but human trials always seems elusive
- phkahler 4y ago>> The drug has been known for a long time but human trials always seems elusive Human trials of this will likely never happen. At least not publicly.
- ltbarcly3 4y agoWhy is that? Literally nobody will do the research in any country in the world because the Illuminati are everywhere?
- GordonS 4y agoMoney and perverse incentives. Clinical trials are expensive, and rapamycin can't be patented. My guess is that, some time in the future, a pharma company will produce and patent an analogue, and then there will be trials.
- LorenPechtel 4y agoWho will fund it (it would be *very* expensive) when they have no hope of recouping the expenses? Consider: We have a likely candidate for a male birth control pill. It's considered quite safe, infertility (while taking it) is a known side effect. All that needs testing is whether it's reliable enough to be used for birth control. Unfortunately, there's a big headache with that--it does *not* stop sperm production so you can't test by having men jack off in a test tube and do a sperm count. Thus testing will be expensive. It's been known about for quite a while and nobody has funded it.
- bookofjoe 4y agohttps://news.ycombinator.com/item?id=32653737 https://news.ycombinator.com/item?id=32653737
- yasp 4y agoFYI one study shows that rapamycin increases amyloid-beta protein plaques in the brains of mice. https://neurosciencenews.com/rapamycin-amyloid-beta-20770/ https://neurosciencenews.com/rapamycin-amyloid-beta-20770/
- shiftpgdn 4y agoAll of the original data around amloyd-beta protein data was faked. A lot of it was even just outright photoshopped. https://www.science.org/content/blog-post/faked-beta-amyloid-data-what-does-it-mean https://www.science.org/content/blog-post/faked-beta-amyloid...
- yasp 4y agoFFS. I forgot about that.
- tptacek 4y agoThat seems like an extremely oversimplified summary of the article you've linked to.
- resoluteteeth 4y agoAmyloid beta may not cause alzheimer's disease, but you still don't want amyloid beta plaques in your brain. They may not themselves be causing damage but they are almost definitely a sign of damage to the brain, so anything that appears to increase them should be handled with extreme caution.
- Traubenfuchs 4y agoSide effects can be pretty serious, bordering into "probably deadly for a few people" territory. https://en.m.wikipedia.org/wiki/Sirolimus https://en.m.wikipedia.org/wiki/Sirolimus
- globular-toast 4y agoThere seems to be a growing trend of generally healthy people looking for drugs/supplements to provide marginal improvements. I can't help thinking it's a sign of a vacuous and unfulfilling life. Instead of spending time and money on drugs to increase your life span, why not spend that time/money on actually living your life? I think this probably comes down to the general boredom that comes from not having a family and not having enough time off work to do anything else worthwhile.
- gruturo 4y ago> There seems to be a growing trend of generally healthy people looking for drugs/supplements to provide marginal improvements. I can't help thinking it's a sign of a vacuous and unfulfilling life. Not sure I agree with your analysis. If I had a vacuous and unfulfilling life, I wouldn't strive to prolong it.
- jonathan-adly 4y agoJust putting this out there, I am a PharmD and this is totally real and the traditional medical establishment is really behind. It is positive effects are beyond doubt - the argument against it is usually "we don't know what the side effects if 100m+ went on it for 20+ years". (which is also 100% true, but that's where patient autonomy comes in). Also, there are some questions about how much are really the positive effects. Anyway, I am tinkering with something in that space - feel free to reach out if you want explore being a co-founder. (email in about)
- Traubenfuchs 4y agoDo you have a personal comment on the long and scary list of side effects it causes?
- actually_a_dog 4y agoOne of the big confounders there is that it typically is given to people undergoing chemotherapy, not otherwise generally healthy people.
- jonathan-adly 4y agoAs someone already said - rapamycin literature is mostly in cancer and transplant patients and with relatively high-doses. The risks are real, but my clinical judgement would lead me to believe that for at least some people the benefits would far outweigh the risks
- BiteCode_dev 4y agoWhat makes me scared about this is that it's immunosuppressive. The immune system is a very important part of the human body, and I worry that taking it could have terrible health impact after years of acting on your body lines of defense. What can you tell me about it?
- jonathan-adly 4y agoYour concern is correct. Suppressing the immune system is a 2-edged sword - a little suppression in the right setting, is extremely beneficial, but go overboard and it is harmful. That's why in a perfect world, we would have large human trials with different dosages and iterate until we can get the maximum benefit and the least harm. The problem is, no one wants to do those trials because rapamycin is cheap and generic. Why would Pharma spend money on something that they can't patent? Also, these kind of trials have to go on for 10+ years at a minimum - which is cost-prohibitive even if it is patentable (not to go in the weeds, but long trials count in the period of exclusivity given to pharma patents). I believe the right approach is to use it off-label, be upfront about the potential risks, and collect lots of data so you can improve as you go. Practical anti-aging so to speak. Another approach is through the NIH grant pathway, but that has a lot of road-blocks as well.
- woshea901 4y agoSome good discussions on rapamycin and longevity on Reddit at https://www.reddit.com/r/Rapamycin/ https://www.reddit.com/r/Rapamycin/
- kvetching 4y ago
- volkfish55 4y agoRead the article. Very depressing. Had no idea about this in Canada.
- varajelle 4y ago> Is it more profitable / money saving to let someone die? "Old" people are expensive because as they age, their body degrade and gets harder and harder to "maintain". If you can prevent aging, then you pay a bit upfront for prevention, but then it get cheaper later. If you want to compare with COVID, it is cheaper to vaccinate everyone than treat the bad cases in a non-vaccinated population
- LordDragonfang 4y ago>People are coerced into killing themselves over the most benign conditions (allergies/depression/etc). That claim is notably absent from your source.
- gavinmckenzie 4y agoA discussion around the numbers of medically-assisted death and what can be done to reduce those numbers through better treatments and services would be a worthy discussion. But it’s inaccurate and needlessly provocative to say that the government is killing people through euthanasia. The government made it possible for people to seek medical assistance in ending their own lives.
- born-jre 4y agohmm science. I wonder what happens if someone overdosed in anti-ageing drug, do they turn into baby.
- firecraker 4y agoNo
- fnordpiglet 4y agoI just have this painting of myself that keeps getting older
- deegles 4y agoI'm 35, have been taking 6mg of rapamycin per week for about a year. It's hard to assign the effects directly to it since I've been taking other supplements and also fixing up my diet + exercise. That being said, I am quite sure that it has reduced general aches and pains, reduced visceral fat and I now have less gray hair compared to when I started. It did slightly increase my glucose and lipids, but still within safe ranges AFAICT. I'll continue to take it until I notice real adverse effects.
- WastingMyTime89 4y agoThis comment is quintessential to the issue with HN. So you are quite young, just had a complete change of lifestyle and your take away is that the beneficial effect comes from the drug you take randomly amongst a cocktail of other things. Interesting.
- deegles 4y agoIt was not a "complete change" in lifestyle. Please don't make assumptions beyond what is written.
- WastingMyTime89 4y ago> fixing up my diet + exercise That’s definitely a complete change in lifestyle. Sorry but not sorry.
- DoreenMichele 4y agoI now have less gray hair compared to when I started. I've never taken rapamycin nor even heard of it before today. I have less gray hair than I had twenty years ago. My understanding is that gray hair suggests a B vitamin deficiency, especially PABA, and a need for adrenal support.
- lps41 4y agoI have less gray hair today than 5 years ago - I think that’s pretty easy for aging men to achieve. ;)
- coolstepa 4y agoThere is a super interesting Radiolab episode on the scientist who discovered Rapamycin, and how he himself was taking it to combat colon cancer. It's really good, and the ending has you quite puzzled. https://radiolab.org/episodes/dirty-drug-and-ice-cream-tub https://radiolab.org/episodes/dirty-drug-and-ice-cream-tub
- tootie 4y agoYeah, the story is absolutely bananas. Not just the personal effort of the scientist, but what in the world even made them think to try any of this. The "Rapa" in the name is from Rapa Nui because this was a chemical found in a random soil sample from Easter Island. This deserves some conspiracy theories.
- enviclash 4y agoIf it is a reliable alternative to a medicine with similar effects, I advocate for fasting. I try doing it once per week until 2pm, and once per month till dinner. At some point (years in my case) it became a pleasure.
- w10-1 4y agoPlease, people. It's bonkers to jump from fruit fly results to humans. Before you take any drug chronically - particularly something KNOWN to block a gene cascade receptor - be sure there are good studies (sufficiently powered, peer-reviewed, phase-III studies in humans with actual endpoints and significant positive results). And be sure the "researchers" you're relying are not just PhD's or retired doctors regurgitating dubious studies. Remember: the essence of a good scam is that it is partly true. Readers will get more longevity from walking instead of reading these studies. Avoiding toenail fungus will improve your lives more. Those have real data behind them.
- quanum_burrito 4y agoI have taken this drug several times of the past 10 years. Each time it had a different effect on my immune system and body systems. The first attempt, it really helped with ridding my body of sustained fluid in my lungs. In more recent times it had helped with the same thing. I have a lung disease and it's not a simple thing to treat so they take care to treat it with some new treatments like rapamycin. I am simply stating that I had different and somewhat difficult times while being on the drug. The lung disease that I have is not common and I am immunocompromised, so being on an immunosuppressant drug like this really made me feel ill. I had the influenza A one year while being on it, as well as a couple of cases of pneumonia that put me into a funk. I am glad I was on it, though because it got me to where I need to be. The liquid form tastes disgusting( ya gonna need a chaser) but the pill is not so bad. It did really effect my joints and muscle systems, I was taking from 2 mg down to .5 mg and each time the doses made me feel extremely tired. I am glad that this med is helping people and I hope all that are taking it, are taking this medication seriously. It is no easy task to be on. Drink lots of water. Best wishes
- mlinksva 4y agohttps://rapamycinstudy.org/ https://rapamycinstudy.org/ is collecting data on off-label use according to https://www.fightaging.org/archives/2022/04/collecting-data-on-people-using-rapamycin-off-label-in-the-context-of-aging/ https://www.fightaging.org/archives/2022/04/collecting-data-... (reasonatllm who runs that site hasn't commented on this site recently, perhaps they are busy running https://www.repairbiotechnologies.com/ https://www.repairbiotechnologies.com/)
- mlinksva 4y agoWhoops, I meant reasonattllm.
- nikolay 4y agoThere are other natural mTOR inhibitors: - EGCG (found in green tea) - Vitamin D3 - Curcumin - Resveratrol - Genistein, an isoflavone found in soybeans - 3,3-Diindolylmethane (DIM), found in cruciferous vegetables - Caffeine
- Fezzik 4y agoTangentially related - it seems there are other things that, if experienced early enough in life, have significant health benefits that are triggered if-and-only-if the catalyst occurs at the right time. For example, pregnancy at a young age is associated with a significant decrease in breast cancer risk. My recollection is this benefit of pregnancy disappears once a women is in her late teens. Our bodies are wildly interesting. https://pubmed.ncbi.nlm.nih.gov/24355762/ https://pubmed.ncbi.nlm.nih.gov/24355762/