6 ms·
Breast cancer drug trial: Woman given months to live told she is cancer free
- krageon 4y ago
- oneoff786 4y agoIntellectual curiosity
- amluto 4y agoIt would be nice if the article said which experimental drug was used.
- Gordonjcp 4y agoIt does. It's right there. Did you read the article?
- amluto 4y agoYes. > experimental medicine combined with Atezolizumab, an immunotherapy drug Atezolizumab is an approved anti-PD-L1 monoclonal antibody. What’s the experimental medicine?
- Gordonjcp 4y agoSeems to have been ninja-edited. It was there earlier.
- elromulous 4y agoIt doesn't. Did _you_ read the article? > an experimental medicine combined with Atezolizumab, an immunotherapy drug. Atezolizumab is not the experimental drug, it's an already approved drug. The drug in question is the unnamed drug it was combined with.
- Gordonjcp 4y agoHuh. It was there earlier. I can't remember what it said, a something-mab, so monoclonal antibody. I wonder why the BBC did a wee ninja-edit? Legal reasons?
- ok123456 4y agoA monocolony antibody.
- ma2t 4y agoThe article doesn't give details, but one of the quoted authors has participated in trials testing anti-ICOS antibody alone or in combination with atezolizumab, with results presented at an ASCO meeting: https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.15_suppl.2624 https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.15_suppl.26... Describes one complete response in TNBC (and 4 partial responses in TNBC and other cancers). Couldn't find a related peer-reviewed journal article on very quick search.
- adamredwoods 4y agoI have not heard of anti-ICOS (Inducible costimulatory receptor) before. Seems specific to TME. KY1044 with mouse models (different authors): https://aacrjournals.org/cancerimmunolres/article/8/12/1568/469583/An-Antibody-Targeting-ICOS-Increases-Intratumoral https://aacrjournals.org/cancerimmunolres/article/8/12/1568/... KY1044 I think is Kymab in Cambridge: https://www.kymab.com/pipeline/ky1044/ https://www.kymab.com/pipeline/ky1044/
- ma2t 4y agoYes, Sanofi licensed from Kymab. There are a few groups targeting ICOS/ICOSL to modulate immune response to tumor (either alone or in combo with PD-1, CTLA-4, etc approaches previously mentioned on HN). Here's one reasonably recent backgrounder on rationale: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003380/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003380/ Still not clear that KY1044 really is the "experimental drug" mentioned in the linked BBC article, since as others have noted the article is pretty thin on detail.
- randcraw 4y agoI agree. There are zillions of stories like this every day. This one does not belong on HN.
- more_corn 4y agoZillions?
- otikik 4y agoThey might be self-reproducing at an uncontrolled rate.
- entropicgravity 4y agoBBC probably has a good reason for publishing this article as opposed to just another cancer spontaneous remission piece.
- krageon 4y agoI wasn't making this statement, because I was assuming good faith on everyone that voted on this article. I genuinely believe I missed what was interesting about the article, which from other responses appears to be the type of experimental drug that was used to cure this lady.
- xeromal 4y agoThe best way to remove something you disagree with is to flag it. If enough have flagged, it will go away. If not, you're probably in the minority.
- bbarn 4y agoWhat to Submit On-Topic: Anything that good hackers would find interesting. That includes more than hacking and startups. If you had to reduce it to a sentence, the answer might be: anything that gratifies one's intellectual curiosity. Off-Topic: Most stories about politics, or crime, or sports, unless they're evidence of some interesting new phenomenon. Videos of pratfalls or disasters, or cute animal pictures. If they'd cover it on TV news, it's probably off-topic.
- krageon 4y agoI was asking what I was missing, not what the rules are. If you'd care to re-read what I ask charitably you will see I am asking for assistance in understanding.
- deleted 4y ago[deleted]
- aaron695 4y ago
- Namari 4y agoShe underwent six months of chemotherapy and a mastectomy in April 2018, followed by 15 cycles of radiotherapy which cleared her body of cancer. But in October 2019 the cancer returned, and scans showed it had spread to her lung, lymph nodes and chest bone and she was told she had a poor prognosis. 'Horrible side effects' Two months later, the mother-of-two was offered a two-year trial at The Christie of an experimental medicine combined with Atezolizumab, an immunotherapy drug. Doctors have told her she is now showing no evidence of the disease.
- jsorrel 4y agoWorth noting that "no evidence of disease" is not the same as cured. My mother was diagnosed with a moderately-aggressive terminal metastatic breast cancer and given months to live, but enjoyed a few years of high quality of life after her doctor cleared her with "no evidence of disease" thanks to an aggressive chemotherapy protocol. That was about 15 years ago. She passed just under 7 years from diagnosis.
- missedthecue 4y agoIs it even possible to prove you are completely cancer free? Or is that like proving a negative?
- florbo 4y agoPossible? Sure! Individual evaluation of every cell in your body is possible. Our capability to do so, however...
- elbigbad 4y agoSo it’s not possible?
- nradov 4y agoAbout 100% of older people have cancer. It's just that many of those cancers are tiny and slow growing, such that they don't cause any serious clinical symptoms and often aren't even detectible with routine screening tests.
- adamredwoods 4y agoNews site at The Christie: https://www.christie.nhs.uk/about-us/news-at-the-christie/latest-news-stories https://www.christie.nhs.uk/about-us/news-at-the-christie/la... Article (no specifics): https://www.christie.nhs.uk/about-us/news-at-the-christie/latest-news-stories/clinical-trial-at-the-christie-cleared-patient-of-cancer https://www.christie.nhs.uk/about-us/news-at-the-christie/la...
- squarefoot 4y agoAny specifics about the drugs involved and availability in the EU for patients willing to try the treatment on themselves? My girlfriend works as a psycho-oncologist; she's in contact with terminal patients on a daily basis.
- nikolay 4y agoI wonder what happened with the Doxycycline, Azithromycin and Vitamin C therapy plus fasting plus exogenous ketones therapy, which was bringing hopes a few years ago.