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The human genome, or a human genome?
by colordrops 5y ago
The human genome, or a human genome?
- deleted 5y ago[deleted]
- marcosdumay 5y agoA single one. But completely mapped.
- amelius 5y agoMan/woman?
- deleted 5y ago[deleted]
- Jailbird 5y agoAlmost certainly.
- mmmrtl 5y agoand yet neither "A complete hydatidiform mole (CHM)"
- tomjakubowski 5y agoThe answer is complicated. The molar pregnancy which CHM13 was made from had two copies of one man's X chromosome and, separately, the project sequenced another man's Y chromosome. https://www.science.org/content/article/most-complete-human-genome-yet-reveals-previously-indecipherable-dna https://www.science.org/content/article/most-complete-human-... The genome’s Y chromosome came from Peshkin, and the rest of the DNA sequenced by the Telomere-to-Telomere (T2T) Consortium comes from a so-called molar pregnancy, a uterine growth that results on rare occasions when a sperm enters an egg that has no chromosomes. The fertilized cell can copy the sperm’s 23 chromosomes, creating two identical sets, and begin to replicate. The question remains open of whether the owner of CHM13’s genome could be identified using public DNA sequences in genealogy databases. Phillippy thinks not because CHM13’s genome only represents one-half of that person’s DNA. Even if it were possible, NHGRI officials argue it would be unethical to reveal him for any reason, including to get consent. Because CHM13 has an X chromosome but no Y, the T2T Consortium added Peshkin’s DNA
- robwwilliams 5y agoNow that is a critical distinction—actually only one half of a single full human genome—one human “haplome”.