5 ms·

FTA: > For human subjects he would replace the sciatic nerve with a chemical cocktail known to stimulate neural growth. Anyone know what this "chemical cockta

FTA: > For human subjects he would replace the sciatic nerve with a chemical cocktail known to stimulate neural growth. Anyone know what this "chemical cocktail" is they're referring to?

xwdv 5y ago
Gotta be Lion’s Mane, or something with it. edit: haters will downvote me but look it up for yourself and upvote if you agree
- LinuxBender 5y ago
  It does appear that is one of the molecules that will help stimulate production [1] but to what degree I can not tell. This might make for some fun reading on PubMed. I take half of those things they list but have no way to measure it. I would avoid commenting on the people down-voting you, that typically just makes it worse. [1] - https://www.neomed-clinic.com/the-best-nerve-growth-factor-supplements-and-how-to-increase-ngf https://www.neomed-clinic.com/the-best-nerve-growth-factor-s...
  - xwdv 5y ago
    Has Lion’s Mane made demonstrable improvements in your intelligence???
    - throwanem 5y ago
      Has it in yours?
      - xwdv 5y ago
        Yes I score several points higher consistently in IQ tests, and I have very wild and vivid dreams.
        1024core 5y ago
        Sorry, meant to reply to you earlier. I got some Lion's Mane capsules from Amazon (though I'm not sure how pure they are; for all I know they crushed up some whitecaps and put those in there). I started with 1/3 the recommended daily dose and started having slight headaches. That was the end of that experiment. :-(
        throwanem 5y ago
        How do you avoid the practice effect as a confounder in frequent IQ testing? Don't get me wrong, if you feel like it helps you then go for it, but objective claims deserve objective evidence.
        jaoa 5y ago
        See https://nootritious.com/nootropics/lions-mane/ https://nootritious.com/nootropics/lions-mane/ Specifically, erinacines and hericenones.
        jiggunjer 5y ago
        That doesn't answer the question about the confounding factor.
        jaoa 5y ago
        You're right. My mistake.
    - LinuxBender 5y ago
      No idea. I really do not have a good way to measure this. I am also quite skeptical of things like IQ tests as a means for measuring such things. I've had some in depth discussions with a friend that is a psychoanalyst about these tests and have read up on them myself. My limited understanding is that they are mostly useful for putting a person into a range but getting exact numbers is not feasible, meaning that the tests giving a specific number is really just an approximation in a range and that also varies by which of the two standard tests is used. If I could get something that could measure exact interaction response times of synapses then perhaps that might be a starting point. The equipment exists but doubt I could even afford the grey-market gear nor do I have a place to put it. One might ask why I take these molecules if I can not measure efficacy. For me it's simple. They are relatively cheap and there are enough studied benefits that even if the gains are marginal I will find that an acceptable net gain in the big picture of my overall health.
- astrange 5y ago
  It's BDNF. Lion's mane is just a supplement which promotes that, but there's other more effective ones. And of course the artificial ones are stronger (Noopept, Semax, ketamine).
  - tux3 5y ago
    >Ketamine, an N-methyl-D-aspartate receptor antagonist and putative antidepressant, may increase synaptic plasticity in prefrontal cortex through higher expression of BDNF. Furthermore, ketamine was shown to change resting-state functional connectivity (RSFC) of dorsomedial prefrontal cortex (dmPFC). That is really fascinating! I wonder whether the lesions observed in chronic, heavy ketamine abuse are related to trophic effects. A glance at search results sugget BNDF seems tighlty regulated, and linked to lesions in other rare conditions (This makes me want to buy neuroscience books! Such an interesting field)
- Melatonic 5y ago
  That shit is tasty as hell too - definitely one of my favourite mushrooms.
- 1024core 5y ago
  I got some Lions Mane capsules, and tried taking them. The recommended dose is 3 capsules per day. I started with 1, but after a couple of days started having slight headaches. I didn't feel like continuing any more.
- jaoa 5y ago
  Maybe not in this case, however Lion's Mane is objectively helpful and has been shown in the literature to be so. Cultures have been eating it in dishes for centuries... As with all nootropics, it's usually better for those who are older. See science: https://nootritious.com/nootropics/lions-mane/ https://nootritious.com/nootropics/lions-mane/
WantonQuantum 5y ago
The Neurotrophic electrode (https://en.wikipedia.org/wiki/Neurotrophic_electrode https://en.wikipedia.org/wiki/Neurotrophic_electrode) wikipedia article says it's Nerve growth factor (https://en.wikipedia.org/wiki/Nerve_growth_factor https://en.wikipedia.org/wiki/Nerve_growth_factor).

FTA: > For human subjects he would replace the sciatic nerve with a chemical cocktail known to stimulate neural growth. Anyone know what this "chemical cocktail" is they're referring to?

xwdv 5y ago

Gotta be Lion’s Mane, or something with it. edit: haters will downvote me but look it up for yourself and upvote if you agree

LinuxBender 5y ago
It does appear that is one of the molecules that will help stimulate production [1] but to what degree I can not tell. This might make for some fun reading on PubMed. I take half of those things they list but have no way to measure it. I would avoid commenting on the people down-voting you, that typically just makes it worse. [1] - https://www.neomed-clinic.com/the-best-nerve-growth-factor-supplements-and-how-to-increase-ngf https://www.neomed-clinic.com/the-best-nerve-growth-factor-s...
- xwdv 5y ago
  Has Lion’s Mane made demonstrable improvements in your intelligence???
  - throwanem 5y ago
    Has it in yours?
    - xwdv 5y ago
      Yes I score several points higher consistently in IQ tests, and I have very wild and vivid dreams.
      - 1024core 5y ago
        Sorry, meant to reply to you earlier. I got some Lion's Mane capsules from Amazon (though I'm not sure how pure they are; for all I know they crushed up some whitecaps and put those in there). I started with 1/3 the recommended daily dose and started having slight headaches. That was the end of that experiment. :-(
      - throwanem 5y ago
        How do you avoid the practice effect as a confounder in frequent IQ testing? Don't get me wrong, if you feel like it helps you then go for it, but objective claims deserve objective evidence.
        jaoa 5y ago
        See https://nootritious.com/nootropics/lions-mane/ https://nootritious.com/nootropics/lions-mane/ Specifically, erinacines and hericenones.
        jiggunjer 5y ago
        That doesn't answer the question about the confounding factor.
        jaoa 5y ago
        You're right. My mistake.
  - LinuxBender 5y ago
    No idea. I really do not have a good way to measure this. I am also quite skeptical of things like IQ tests as a means for measuring such things. I've had some in depth discussions with a friend that is a psychoanalyst about these tests and have read up on them myself. My limited understanding is that they are mostly useful for putting a person into a range but getting exact numbers is not feasible, meaning that the tests giving a specific number is really just an approximation in a range and that also varies by which of the two standard tests is used. If I could get something that could measure exact interaction response times of synapses then perhaps that might be a starting point. The equipment exists but doubt I could even afford the grey-market gear nor do I have a place to put it. One might ask why I take these molecules if I can not measure efficacy. For me it's simple. They are relatively cheap and there are enough studied benefits that even if the gains are marginal I will find that an acceptable net gain in the big picture of my overall health.
astrange 5y ago
It's BDNF. Lion's mane is just a supplement which promotes that, but there's other more effective ones. And of course the artificial ones are stronger (Noopept, Semax, ketamine).
- tux3 5y ago
  >Ketamine, an N-methyl-D-aspartate receptor antagonist and putative antidepressant, may increase synaptic plasticity in prefrontal cortex through higher expression of BDNF. Furthermore, ketamine was shown to change resting-state functional connectivity (RSFC) of dorsomedial prefrontal cortex (dmPFC). That is really fascinating! I wonder whether the lesions observed in chronic, heavy ketamine abuse are related to trophic effects. A glance at search results sugget BNDF seems tighlty regulated, and linked to lesions in other rare conditions (This makes me want to buy neuroscience books! Such an interesting field)
Melatonic 5y ago
That shit is tasty as hell too - definitely one of my favourite mushrooms.
1024core 5y ago
I got some Lions Mane capsules, and tried taking them. The recommended dose is 3 capsules per day. I started with 1, but after a couple of days started having slight headaches. I didn't feel like continuing any more.
jaoa 5y ago
Maybe not in this case, however Lion's Mane is objectively helpful and has been shown in the literature to be so. Cultures have been eating it in dishes for centuries... As with all nootropics, it's usually better for those who are older. See science: https://nootritious.com/nootropics/lions-mane/ https://nootritious.com/nootropics/lions-mane/

WantonQuantum 5y ago

The Neurotrophic electrode (https://en.wikipedia.org/wiki/Neurotrophic_electrode https://en.wikipedia.org/wiki/Neurotrophic_electrode) wikipedia article says it's Nerve growth factor (https://en.wikipedia.org/wiki/Nerve_growth_factor https://en.wikipedia.org/wiki/Nerve_growth_factor).