5 ms·

Hydroxychloroquine was only conclusively proven to have no effect on already hospitalized patients with severe covid. It is now known that this is the point in

Hydroxychloroquine was only conclusively proven to have no effect on already hospitalized patients with severe covid. It is now known that this is the point in the disease where the significant portion of viral activity has already taken place, so it would make sense that an anti-viral would no longer do anything at this point. Last I checked there were no large trials for its use as early treatment, but some small trials do show that it can be effective if used early. Here’s a summary: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534595/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534595/

tamaharbor 5y ago
Sorry Dude, this was a Trump thing, and you are probably getting a lot of down votes for it. But I agree we do need to treat early, acquire natural immunity, and not worry so much about continual vaccines and boosters.
- jjeaff 5y ago
  I don't think there is any immunologist, virologist, or infectious disease doctor out there that agrees with your idea that you are better off getting infected with a disease than getting immunized for that disease.
  - wsc981 5y ago
    > with your idea that you are better off getting infected with a disease than getting immunized for that disease. With regards to COVID, no one is getting immunised through the vaccines right now as I understand?
    - kadoban 5y ago
      Immunization: A process by which a person becomes protected against a disease through vaccination. This term is often used interchangeably with vaccination or inoculation. https://www.cdc.gov/vaccines/vac-gen/imz-basics.htm https://www.cdc.gov/vaccines/vac-gen/imz-basics.htm
  - nradov 5y ago
    I encourage everyone eligible to get vaccinated, however vaccination doesn't reliably prevent infection. Eventually most vaccinated people will be infected. Fortunately the vaccines are pretty good at preventing deaths. https://www.cnbc.com/2021/08/12/herd-immunity-is-mythical-with-the-covid-delta-variant-experts-say.html https://www.cnbc.com/2021/08/12/herd-immunity-is-mythical-wi...
treeman79 5y ago
Need good data on autoimmune patients who take it. A high risk group in general. How did they fair in aggregate? I started Hydroxychloroquine about six months before covid for Sjogrens. Stopped after getting and recovering from Covid. Was out of commission for a month. Had a couple of rough nights and about six months of intense clotting. I had to double my blood thinners. Of course no idea if it would have been worse off or not. On autoimmune forums it ranges from very effective with or without side effects to useless. It was a huge help for my condition, but side effects were to much.
rsfern 5y ago
I don’t know, there are only two randomized controlled trials for early treatment discussed in this paper. Neither had statistically significant results, but the review authors speculate that better statistical power would confirm the trend anyway… I tried looking for something more recent, but I only found this actual meta analysis that I don’t think covers early treatment, but is not favorable for hydroxychloroquine as a treatment for Covid. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449662 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449662

tamaharbor 5y ago

Sorry Dude, this was a Trump thing, and you are probably getting a lot of down votes for it. But I agree we do need to treat early, acquire natural immunity, and not worry so much about continual vaccines and boosters.

jjeaff 5y ago
I don't think there is any immunologist, virologist, or infectious disease doctor out there that agrees with your idea that you are better off getting infected with a disease than getting immunized for that disease.
- wsc981 5y ago
  > with your idea that you are better off getting infected with a disease than getting immunized for that disease. With regards to COVID, no one is getting immunised through the vaccines right now as I understand?
  - kadoban 5y ago
    Immunization: A process by which a person becomes protected against a disease through vaccination. This term is often used interchangeably with vaccination or inoculation. https://www.cdc.gov/vaccines/vac-gen/imz-basics.htm https://www.cdc.gov/vaccines/vac-gen/imz-basics.htm
- nradov 5y ago
  I encourage everyone eligible to get vaccinated, however vaccination doesn't reliably prevent infection. Eventually most vaccinated people will be infected. Fortunately the vaccines are pretty good at preventing deaths. https://www.cnbc.com/2021/08/12/herd-immunity-is-mythical-with-the-covid-delta-variant-experts-say.html https://www.cnbc.com/2021/08/12/herd-immunity-is-mythical-wi...

treeman79 5y ago

Need good data on autoimmune patients who take it. A high risk group in general. How did they fair in aggregate? I started Hydroxychloroquine about six months before covid for Sjogrens. Stopped after getting and recovering from Covid. Was out of commission for a month. Had a couple of rough nights and about six months of intense clotting. I had to double my blood thinners. Of course no idea if it would have been worse off or not. On autoimmune forums it ranges from very effective with or without side effects to useless. It was a huge help for my condition, but side effects were to much.

rsfern 5y ago

I don’t know, there are only two randomized controlled trials for early treatment discussed in this paper. Neither had statistically significant results, but the review authors speculate that better statistical power would confirm the trend anyway… I tried looking for something more recent, but I only found this actual meta analysis that I don’t think covers early treatment, but is not favorable for hydroxychloroquine as a treatment for Covid. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449662 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449662