6 ms·
Statistical adjustments at a population level will be much less useful than the pre post design above. Getting estimates from the same people will provide a mu
by disgruntledphd2 5y ago
Statistical adjustments at a population level will be much less useful than the pre post design above.
Getting estimates from the same people will provide a much lower variance estimaion of any potential effect.
Also, adding hospital records to this study would potentially provide a better estimation.
All studies have flaws, but this one does look pretty reasonable (the principal components method used should have been better described, for instance, and confidence bounds on the effect sizes would have been super useful).
- yourenotsmart 5y agoThe "pre post" is not much of a design, unless we've had a long-term practice to force random healthy people into scanning their brains, or we have a time machine.
- nradov 5y agoThere are always medical studies running for other purposes that involve doing brain scans on otherwise healthy people. One of my relatives participated in such a study. Presumably those same subjects could be enrolled in a "pre post" study for COVID-19 effects.
- disgruntledphd2 5y agoNonetheless, it would be a better design. Horribly impractical, but really useful.