3 ms·

Could this be a factor in near zero morbidity rates for young children? They clearly drink more milk and spend more time in the sun than the average adult.

by koolba 6y ago

adventured 6y ago
One of the reasons (plausibly there are multiple reasons) for that may have to do with children having fewer ACE2 enzymes lining the nasal cavity: From May: https://jamanetwork.com/journals/jama/fullarticle/2766522 https://jamanetwork.com/journals/jama/fullarticle/2766522 "The authors evaluated gene expression in nasal epithelial samples collected as part of a study involving patients with asthma from 2015 to 2018. The nasal epithelium is one of the first sites of infection with SARS-CoV-2, and the investigators probed for the expression of the cell surface enzyme angiotensin-converting enzyme 2 (ACE2), which has been proven to bind to SARS-CoV-2 spike protein and promote internalization of the virus into human cells. Among a cohort of 305 patients aged 4 to 60 years, older children (10-17 years old; n = 185), young adults (18-24 years old; n = 46), and adults (≥25 years old; n = 29) all had higher expression of ACE2 in the nasal epithelium compared with younger children (4-9 years old; n = 45), and ACE2 expression was higher with each subsequent age group after adjusting for sex and asthma."
tpmx 6y ago
Background to this comment: Vitamin D is commonly artifically added to milk.
- pbhjpbhj 6y ago
  I'd imagine this varies by country, and that should give relatively easy statistical comparisons?
  - tpmx 6y ago
    After spending the past 7 months as an amateur statistician I have found that nothing is easy when you want compare different countries.
    - mhh__ 6y ago
      Comparing within the EU is fairly OK. Testing a hypothesis like the above could be easier if you remember that the US can be divided up like the EU too - that way you have fairly geographically sparse but hopefully methodologically similarly recorded data.
      - Fnoord 6y ago
        > Comparing within the EU is fairly OK. The company I work at do data analysis on COVID-19. We cannot compare within EU as of now; only within the country. Even then, data (e.g. from hospitals) needs to be "standardized".
- deleted 6y ago
  [deleted]
JoshTko 6y ago
There are a number of other corroborating scenarios. Homeless populations having much higher rates of infections but much higher rates of being asymptotic. Much lower mortality rates in Central African countries.

Could this be a factor in near zero morbidity rates for young children? They clearly drink more milk and spend more time in the sun than the average adult.

by koolba 6y ago

Could this be a factor in near zero morbidity rates for young children? They clearly drink more milk and spend more time in the sun than the average adult.

adventured 6y ago

One of the reasons (plausibly there are multiple reasons) for that may have to do with children having fewer ACE2 enzymes lining the nasal cavity: From May: https://jamanetwork.com/journals/jama/fullarticle/2766522 https://jamanetwork.com/journals/jama/fullarticle/2766522 "The authors evaluated gene expression in nasal epithelial samples collected as part of a study involving patients with asthma from 2015 to 2018. The nasal epithelium is one of the first sites of infection with SARS-CoV-2, and the investigators probed for the expression of the cell surface enzyme angiotensin-converting enzyme 2 (ACE2), which has been proven to bind to SARS-CoV-2 spike protein and promote internalization of the virus into human cells. Among a cohort of 305 patients aged 4 to 60 years, older children (10-17 years old; n = 185), young adults (18-24 years old; n = 46), and adults (≥25 years old; n = 29) all had higher expression of ACE2 in the nasal epithelium compared with younger children (4-9 years old; n = 45), and ACE2 expression was higher with each subsequent age group after adjusting for sex and asthma."

tpmx 6y ago

Background to this comment: Vitamin D is commonly artifically added to milk.

pbhjpbhj 6y ago
I'd imagine this varies by country, and that should give relatively easy statistical comparisons?
- tpmx 6y ago
  After spending the past 7 months as an amateur statistician I have found that nothing is easy when you want compare different countries.
  - mhh__ 6y ago
    Comparing within the EU is fairly OK. Testing a hypothesis like the above could be easier if you remember that the US can be divided up like the EU too - that way you have fairly geographically sparse but hopefully methodologically similarly recorded data.
    - Fnoord 6y ago
      > Comparing within the EU is fairly OK. The company I work at do data analysis on COVID-19. We cannot compare within EU as of now; only within the country. Even then, data (e.g. from hospitals) needs to be "standardized".
deleted 6y ago
[deleted]

JoshTko 6y ago

There are a number of other corroborating scenarios. Homeless populations having much higher rates of infections but much higher rates of being asymptotic. Much lower mortality rates in Central African countries.