5 ms·
This is a misnomer according to a recent guest on the Joe Rogan podcast. Granted that might not be the best source, I reflected on that and the chemistry makes
by yomly 6y ago
This is a misnomer according to a recent guest on the Joe Rogan podcast.
Granted that might not be the best source, I reflected on that and the chemistry makes sense.
Vitamins primarily will leach out via osmosis. Osmosis works by gradients. This probably means an exponential decay of absorption relative to concentration and as you consume more, your body will waste progressively more and uptake will be less efficient per unit mass.
But it's not boolean/binary - your body doesn't suddenly stop everything after an arbitrary cutoff.
There's an elegance to this - it means there is a lot of leeway in consumption so it is hard to overdose. But it also means that if you "need" to increase bioavailability of a water soluble vitamin, you can simply consume more orally and it will increase. It just becomes progressively more wasteful to do via that means. (IV is more efficient in this manner)
So I suppose wasteful is not the same as pointless/useless
- partyboat1586 6y agoDr Rhonda Patrick was the guest if anyone is interested. Worth watching with paper and pen (or digital equivalent).
- nradov 6y agoShow notes are here. https://www.foundmyfitness.com/episodes/jre-1474 https://www.foundmyfitness.com/episodes/jre-1474
- 0-_-0 6y ago2 interesting references to vitamin D studies: 00:29:32 - In the Philippines, every standard deviation increase in serum vitamin D was associated with an 8 times more likely chance to have a mild rather than severe COVID-19 outcome and a 20 times more likely chance to have a mild rather than critical outcome. 00:30:37 - In Indonesia, 98.9% of patients with vitamin D deficiency died, 88% of patients with vitamin D insufficiency died but only 4% of patients with sufficient vitamin D died.
- nradov 6y agoDirect links to the papers: Alipio, Mark, Vitamin D Supplementation Could Possibly Improve Clinical Outcomes of Patients Infected with Coronavirus-2019 (COVID-19) (April 9, 2020). Available at SSRN: https://ssrn.com/abstract=3571484 https://ssrn.com/abstract=3571484 or http://dx.doi.org/10.2139/ssrn.3571484 http://dx.doi.org/10.2139/ssrn.3571484 Raharusun, Prabowo and Priambada, Sadiah and Budiarti, Cahni and Agung, Erdie and Budi, Cipta, Patterns of COVID-19 Mortality and Vitamin D: An Indonesian Study (April 26, 2020). Available at SSRN: https://ssrn.com/abstract=3585561 https://ssrn.com/abstract=3585561 or http://dx.doi.org/10.2139/ssrn.3585561 http://dx.doi.org/10.2139/ssrn.3585561
- James_Henry 6y agoThis could simply mean that metabolic syndrome is the reason these people die. My guess is it's not just a matter of going in the sun more or taking vitamin D supplements. If you have a vitamin D deficiency in the tropics, or even elsewhere, it can be a symptom of kidney or liver or other metabolic issues. Supplemental vitamin D can fix the deficiency/insufficiency, but they may not cure the underlying cause.
- partyboat1586 6y agoDamn, I already took all my own notes! Thanks for this.
- pstuart 6y agoShe's worth following if you're interested in health and longevity. https://www.foundmyfitness.com/ https://www.foundmyfitness.com/