4 ms·

Stem cell competition orchestrates skin homeostasis and ageing

39 points by evo_9 8y ago

pmarreck 8y ago
Any word on what can stimulate production of COL17A1, or is it still too new a research area?
- medymed 8y ago
  From the paper: "We identified two chemicals—Y27632 and apocynin—that induced COL17A1 expression in keratinocytes. To test whether these compounds increased the self-renewing capabilities of epidermal stem cells in vitro, we performed colony-formation assays40,41; Y-27632 increased colony number, and both drugs increased colony size (Extended Data Fig. 9m–p). Application of these drugs to full-thickness skin wounds significantly promoted wound repair, similarly to the effect of overexpression of human COL17A1 in mice (Extended Data Fig. 9q–s). Collectively, these data show that COL17A1-inducing drugs promote skin wound healing through re-epithelization of the wound edge with epidermal stem cell expansion, and point towards directions for facilitating skin regeneration and reducing skin ageing." It seems like one very promising application could be in promoting wound healing in certain populations e.g. venous stasis ulcers, pressure ulcers, and many other chronic wounds that don't heal well especially in the elderly (if the treatment were safe). That would be fantastic. But the use of the term anti-aging effects in this paper is suspect. COL17A is part of the basement membrane holding together the thin epidermis and thicker underlying dermis, whereas much aging related research that focuses on 'collagen' loss relates to the amount of collagen I in the thicker underlying dermis. Loss of dermal collagen I with aging is associated with cosmetic changes like thin skin (dermal thinning) and wrinkling. It would be surprising if increased expression of COL17A1 at the basement membrane dramatically induced cosmetic anti-aging effects in the sense of increased level of collagen I in the dermis. Also, it may be a band-aid for one particular cellular function that is important for local tissue structure and cell functions, but the underlying causes of general aging change in cells (mutation accumulation, UV damage, oxidative damage, etc) probably are not being addressed or reversed.
- PierredeFermat 8y ago
  It's two compounds that they've identified; apocynin and Y-27632. A comment here (https://news.nukleosome.com/t/anti-aging-discovery-could-lead-to-restorative-skin-treatments/700 https://news.nukleosome.com/t/anti-aging-discovery-could-lea...) explains it a bit, quoting the authors; "We selected candidate chemicals that potentially increased the stem cell property [apocynin] or reduced production of reactive oxygen species [Y-27632] based on in silico information."
sagebird 8y ago
I hope you will not take this as me encouraging a conspiracy theory — I sometimes wonder what would happen if someone stumbled upon a simple, robust and general method for halting aging using the likes of stem cells. Ordinarily this sort of discovery happens in plain sight— over many years of acedemic research, published papers, animal studies and human studies. But suppose it occurred in a private lab and was kept, basically, secret. I could imagine a government being hesitant to release this info if they thought lay people could implement t the treatment themselves and live multi thousands of years. But I also suspect that a few rich and powerful people would want to have a go. It would be interesting to see how they conceal the fact— do they fake death multiple times? Even if a government is able to restrict interested billionaires and powerful people from participating, they may feel a need to keep a population of long span humans— as a competitive hedge against other nations’ possible participation. It’s possible that this is happening now, though I know of absolutely no evidence of that.
- blockmarker 8y ago
  I don't believe that will happen, because that treatment would massively boost the economy. Nowadays we have to spend around 23 years until a person can be productive, then they have to learn to be more efficient, and in a few years they have children and focus less on their job. As well as they becoming older, losing efficiency until they retire and then they consume the resources of social security for twenty or more years. Eternal youth would be so good to the economy that it would never be hidden.
  - throwawaymanbot 8y ago
    I don't agree. I think it would be like the Spanish coming to the Americas. There would be an earth war over this. Why should the Rich get it for themselves while everyone else has to die from now curable diseases. Society and economics would collapse. What resources would an earth have for people that live 1000 years? The transition would ruin the planet.
ilaksh 8y ago
I really doubt its just this one thing that is responsible for aging even just for skin. I subscribe to the SENS theory of aging (sens.org).

39 points by evo_9 8y ago

pmarreck 8y ago

Any word on what can stimulate production of COL17A1, or is it still too new a research area?

medymed 8y ago
From the paper: "We identified two chemicals—Y27632 and apocynin—that induced COL17A1 expression in keratinocytes. To test whether these compounds increased the self-renewing capabilities of epidermal stem cells in vitro, we performed colony-formation assays40,41; Y-27632 increased colony number, and both drugs increased colony size (Extended Data Fig. 9m–p). Application of these drugs to full-thickness skin wounds significantly promoted wound repair, similarly to the effect of overexpression of human COL17A1 in mice (Extended Data Fig. 9q–s). Collectively, these data show that COL17A1-inducing drugs promote skin wound healing through re-epithelization of the wound edge with epidermal stem cell expansion, and point towards directions for facilitating skin regeneration and reducing skin ageing." It seems like one very promising application could be in promoting wound healing in certain populations e.g. venous stasis ulcers, pressure ulcers, and many other chronic wounds that don't heal well especially in the elderly (if the treatment were safe). That would be fantastic. But the use of the term anti-aging effects in this paper is suspect. COL17A is part of the basement membrane holding together the thin epidermis and thicker underlying dermis, whereas much aging related research that focuses on 'collagen' loss relates to the amount of collagen I in the thicker underlying dermis. Loss of dermal collagen I with aging is associated with cosmetic changes like thin skin (dermal thinning) and wrinkling. It would be surprising if increased expression of COL17A1 at the basement membrane dramatically induced cosmetic anti-aging effects in the sense of increased level of collagen I in the dermis. Also, it may be a band-aid for one particular cellular function that is important for local tissue structure and cell functions, but the underlying causes of general aging change in cells (mutation accumulation, UV damage, oxidative damage, etc) probably are not being addressed or reversed.
PierredeFermat 8y ago
It's two compounds that they've identified; apocynin and Y-27632. A comment here (https://news.nukleosome.com/t/anti-aging-discovery-could-lead-to-restorative-skin-treatments/700 https://news.nukleosome.com/t/anti-aging-discovery-could-lea...) explains it a bit, quoting the authors; "We selected candidate chemicals that potentially increased the stem cell property [apocynin] or reduced production of reactive oxygen species [Y-27632] based on in silico information."

sagebird 8y ago

I hope you will not take this as me encouraging a conspiracy theory — I sometimes wonder what would happen if someone stumbled upon a simple, robust and general method for halting aging using the likes of stem cells. Ordinarily this sort of discovery happens in plain sight— over many years of acedemic research, published papers, animal studies and human studies. But suppose it occurred in a private lab and was kept, basically, secret. I could imagine a government being hesitant to release this info if they thought lay people could implement t the treatment themselves and live multi thousands of years. But I also suspect that a few rich and powerful people would want to have a go. It would be interesting to see how they conceal the fact— do they fake death multiple times? Even if a government is able to restrict interested billionaires and powerful people from participating, they may feel a need to keep a population of long span humans— as a competitive hedge against other nations’ possible participation. It’s possible that this is happening now, though I know of absolutely no evidence of that.

blockmarker 8y ago
I don't believe that will happen, because that treatment would massively boost the economy. Nowadays we have to spend around 23 years until a person can be productive, then they have to learn to be more efficient, and in a few years they have children and focus less on their job. As well as they becoming older, losing efficiency until they retire and then they consume the resources of social security for twenty or more years. Eternal youth would be so good to the economy that it would never be hidden.
- throwawaymanbot 8y ago
  I don't agree. I think it would be like the Spanish coming to the Americas. There would be an earth war over this. Why should the Rich get it for themselves while everyone else has to die from now curable diseases. Society and economics would collapse. What resources would an earth have for people that live 1000 years? The transition would ruin the planet.

ilaksh 8y ago

I really doubt its just this one thing that is responsible for aging even just for skin. I subscribe to the SENS theory of aging (sens.org).