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Scientists are transplanting faeces into obese people with type 2 diabetes
- jacknews 8y agoNo shit, this has been going on for a while I thought? The idea being the gut microbiome is partly to blame for obesity.
- 8draco8 8y agoThe main source of obesity is to high calorie intake.
- cortic 8y agoThats like saying the main source of famine is to low calorie intake. It may be technically true but it misses almost every part of the problem.
- 8draco8 8y agoIf you want go down that road I will say that reason of high calorie intake is not gut bacteria. In majority of cases it’s bad eating habits. Too much sugars, too much fats. Education is the greatest weapon against obesity that we have.
- zaarn 8y agoThere is some evidence that your gut flora and fauna influences your appetite and calorie intake [https://www.nature.com/articles/nutd201121 https://www.nature.com/articles/nutd201121]
- DanBC 8y ago>Education is the greatest weapon It doesn't seem to be working.
- cortic 8y ago>Education is the greatest weapon against obesity that we have. Yet the most educated societies have the worst problems with obesity. A fair statistical case could be made that Education causes obesity, albeit it too would miss most of the problem. >reason of high calorie intake is not gut bacteria [majority of cases] Most research I've read, especially around epigenetics, the thrifty metabolism and the Dutch hunger winter studies, all show a strikingly different biome of gut bacteria in [an overwhelming majority] of obese individuals compared to average bmi non-thrifty metabolic people.
- atombender 8y agoI don't have the study at hand, but there's evidence that healthy, lean people excrete unused calories whereas obese people don't. In other words, the body adapts to calorie intake, and it's not just a simple formula of "calories in/out".
- potiuper 8y agoFecal microbiota transplants are more pseudoscience than science. Research should be done to identify the most relevant microbes within fecal transplants, which could then be isolated and manufactured via industrial fermentation; such standardized products would be more scalable, would reduce the risk of infections from unwanted microbes, and would improve the scientific study of the approach, since the same substance would be administered each time. https://en.wikipedia.org/wiki/Fecal_microbiota_transplant#Research https://en.wikipedia.org/wiki/Fecal_microbiota_transplant#Re... This would remove many unnecessary and correlated variables associated with feces transfer, especially when it is being transferred "with the liquid injected through people's noses"! This could benefit from either a medical ethics review or an editorial review of the article.
- zyxzevn 8y agoStill looking for donors..
- test6554 8y agoNever go ATM
- JeanMarcS 8y agoFor those who just read the beginning of the article “It’s in liquid form and injected through a tube in the patient’s nose. There is no smell or taste associated with it – it’s all very purified.”
- hourislate 8y agoIt was my understanding that T2D is due to Insulin Resistance and the reason most folks gain weight is that an excess of Insulin will do that. Doing a Fecal Transplant seems more like a band aid solution for T2D since unhealthy eating habits will just kill off the good bacteria over time. I'm curious if these folks tried to lower sugar intake in all forms and reduce their eating window to 8 hours and whether that would have lowered Insulin Production and caused an increase in Insulin sensitivity. How difficult it is for people to change lifestyle habits to fix their hormonal unbalance when it comes to obesity.
- BurningFrog 8y agoI think this article describes a new understanding emerging.
- chiefalchemist 8y ago"How difficult it is for people to change lifestyle habits to fix their hormonal unbalance when it comes to obesity." Sadly, evidently, very. Annecdotally, most ppl don't seem to connect what they consume with their health. There's no sense of garbage in...feel like garbage. I'm not sure what they're tbinking but when I look at their bodies and then at their shopping cart (at the super market) disconnect wins 9 of 10 times. Furthermore, abnormal has been normalized. Humans are naturally wired to assume the norm. They see what's around them and naturally presume it's okay. Obesity is the new black. Soda, cookies, etc. (and the advertisement there of) is ubiquitous. Honesty is now called "fat shaming." I understand there are people who have health issue the cause them to be obese. The rest a simply negligent. Sadly, it's not PC to say such truths. p.s. Editorial: How is it, in the face of the obesity crisis (which directly contributes to increased healthcare costs), that the adults who lead the Girl Scouts are still pushing cookies. The hypocrisy and absurdity boggles my mind.
- hnuser355 8y agoIt’s normal because most people’s lives and normal obligations are difficult enough relative to their abilities that they have issue proactively managing these things. It’s actually a matter of life and death what you eat in many cases and should be prioritized, but this is frankly not a viewpoint that people are going to respond well to you taking in most cultural milieus
- tdburn 8y agoFMT transplants have a very high success rate for treating C Diff infections that don't respond to antibiotics. Something like 70-80% success.
- taf2 8y agoSource?
- curtis 8y agoFecal Transplantation for Recurrent Clostridium difficile Infection in Older Adults: A Review - https://onlinelibrary.wiley.com/doi/abs/10.1111/jgs.12378 https://onlinelibrary.wiley.com/doi/abs/10.1111/jgs.12378 Fecal Microbiota Transplantation for Clostridium difficile Infection: A Systematic Review - https://annals.org/aim/article-abstract/2288521/fecal-microbiota-transplantation-clostridium-difficile-infection-systematic-review?doi=10.7326%2fM14-2693 https://annals.org/aim/article-abstract/2288521/fecal-microb... I just cribbed these from the Wikipedia article at https://en.wikipedia.org/wiki/Clostridioides_difficile_infection#Stool_transplant https://en.wikipedia.org/wiki/Clostridioides_difficile_infec... so I don't know if there's better or more recent studies.
- carbocation 8y agoHere is a comparison of capsule-based FMT versus colonoscopy-based FMT, in which either approach had a (very) high success rate. https://www.ncbi.nlm.nih.gov/pubmed?term=29183074 https://www.ncbi.nlm.nih.gov/pubmed?term=29183074
- GeekyBear 8y agoThe numbers I've seen are higher than that. The Mayo Clinic has posted numbers for a couple of different clinic locations that have seen a a 90% success rate. https://www.mayoclinic.org/medical-professionals/digestive-diseases/news/fmt-demonstrates-consistently-high-success-rates-for-recurrent-cdi/mac-20429966 https://www.mayoclinic.org/medical-professionals/digestive-d...
- staggering 8y agoThis is interesting. I was wondering if anyone is working on something similar meant for nasal area? Chronic sinus infections, thick mucus and various other annoying nasal afflictions could possibly be solved by something like this?
- whoanow 8y agoI have no idea if people are doing this yet, but I would love to find out more. Doing a nasal rinse with Xylitol can break down thick and lodged mucus to get things moving again. Also lactobacillus sakei seems to fight off sinus infections according to some.
- lukestevens 8y agoI wondered the same thing, and came across this guy who has been documenting his experimentation and purported success with self-administered bacteria from kimchi... https://lactobacto.com/2019/01/17/what-else-can-lactobacillus-sakei-treat/ https://lactobacto.com/2019/01/17/what-else-can-lactobacillu... :)