7 ms·
CRISPR is Going to be Replaced
- elicash 8y agoSorry, is this verifiable elsewhere? I'm automatically skeptical of anybody with a free WP theme with no About section who is pushing a stock, and right now this is #1 on Hacker News.
- Zeratoss 8y agoI mean the paper is really the interesting part http://www.pnas.org/content/early/2018/07/16/1802343115 http://www.pnas.org/content/early/2018/07/16/1802343115
- shawnz 8y agoAnd furthermore, copy text that was clearly not even edited
- ereyes01 8y agoDoes everyone with useful information need to be a skilled web designer to be credible?
- elicash 8y agoObviously not. But it's like the old twitter egg profile accounts. It was so easy to create a fake egg account that I'm not going to take my investment advice from them, especially if they don't have information about who they are readily available. It's deserving of an extra level of skepticism is all I'm saying. If you don't agree with that very basic idea, then I don't know what to tell you.
- pbhjpbhj 8y agoThere's an interesting dovetail with comments on the post https://news.ycombinator.com/item?id=18389080 https://news.ycombinator.com/item?id=18389080 about anonymity and mathematical proofs.
- tyingq 8y agoSome backstory on the author: https://en.m.wikipedia.org/wiki/Josiah_Zayner https://en.m.wikipedia.org/wiki/Josiah_Zayner And evidence of a tie to the site this is posted on: https://mobile.twitter.com/4LOVofScience/status/1059567392337014784 https://mobile.twitter.com/4LOVofScience/status/105956739233... Edit: But, yeah, site needs an "about us" page.
- skosch 8y agoThanks, I had no idea it was that guy!
- codeulike 8y agoJosiah knows a bit about CRISPR, having injected it into himself - https://www.theguardian.com/science/2017/dec/24/josiah-zayner-diy-gene-editing-therapy-crispr-interview https://www.theguardian.com/science/2017/dec/24/josiah-zayne... But yeah this antisense site seems to be linked to him (antisense links to the-odin which is Josiah's site selling bio-hacking kits) So: a) He might know what he's talking about but b) he's using his own platform to give this opinion Make of that what you will.
- amelius 8y agoThe article uses layman's language with no reference to an authority, so indeed, we should be skeptical.
- abcc8 8y agoHere is a link to the study (Open access at PNAS): http://www.pnas.org/content/pnas/115/31/E7379.full.pdf?casa_token=UUnTkoOcuXkAAAAA:V6TllVTjL5wz5bGeX-iH6Vz_iaPzKd40mixi5ro3n6Nhp6RZpqJI8UUCURehhL-K2CiHg7CiDrEZ http://www.pnas.org/content/pnas/115/31/E7379.full.pdf?casa_...
- folli 8y agoCRISPR is most likely more versatile in that in can be used for gene knockouts directly (introduction of frameshifts by microhomology-mediated end joining) and in in other models (e.g. in plants not only in eukaryotic cells as adenoviruses).
- aurizon 8y agoYou have to bear in mind that CRISPR was a molecular monkey wrench that bacteria throw into the works of a phage (bacterial virus) - a relatively small and accessible single string genome, with the purpose to quickly wreck it to save their tiny existence, whereas higher organisms have their genes organised in densely packed assemblies that are convoluted and hard to access with the needed precision. See https://en.wikipedia.org/wiki/Chromosome https://en.wikipedia.org/wiki/Chromosome
- EdgarVerona 8y agoThis reads like a pump-and-dump article.
- dnautics 8y agoI have large doubts about zayners scientific judgement, but I would be surprised if zayner were pumping and dumping anything.
- SOLAR_FIELDS 8y agoIt certainly seems fishy to be talking about a somewhat-overlooked groundbreaking scientific discovery and then pivot to talking about the stock price of the owning company. Not a biologist so I can't speak to the veracity of the content of the article but from an outsider's perspective it certainly does check a lot of pump-and-dump boxes.
- meowface 8y ago>I have large doubts about zayners scientific judgement Because he recklessly injected himself with CRISPR, or for other reasons as well?
- twodave 8y agoGiven that one of the other articles in the same category of that blog is a futuristic science fiction fantasy excerpt about gene doping, not sure this really belongs on HN.
- kikikiki 8y agoThe CRISPR replacement's patent holder's stock has FALLEN. BETTER BUY FAST GUISE!!11
- perlgeek 8y agoIt seems to me that in general culture, people just mean "virus-based gene editing" when talking about CRISPR. The precise virus used typically is only interesting when you're actually doing it, and I suspect that in the next years, we'll see more uses of other viruses for comparable purposes.
- sharpshadow 8y agoVery interested in what the future holds for this!! Ways to explain the falling stock price is manipulation to drop it further to rebuy then cheap, lowering the price for a coming company sale and lowering the value to force the company to consider a sale. Possibility one could be appended with the intent to rebuy so much that you will have influence on the further way of this and in the worst case blocking further science of that department. Maybe check who is responsible for that stock value drop. Just ideas everything else is also possible.
- viggity 8y ago"Stem cell-derived clade F AAVs mediate high-efficiency homologous recombination-based genome editing" SCDFAAVMHEHRBGE doesn't have quite the same ring as "CRISPR", they need some marketing people stat!