4 ms·
> Are there just so many of them in the cytosol that through sheer numbers, there's enough random chance they'll just shuttle into place when the polymerase nee
by dflock 9y ago
> Are there just so many of them in the cytosol that through sheer numbers, there's enough random chance they'll just shuttle into place when the polymerase needs them?
Yes. Everything at that scale is very small, very close together and moving very, very fast.
This kind of thing is very common at the cellular level: have a receptor/channel/process/thing that only one precise 3d molecule can fit into - and then just wait.
As long as there's a process somewhere to make/acquire that molecule, then one will be along in a few nanoseconds or so, depending on the concentration. In the meantime the recipient will just wait.
In this way otherwise independent processes can regulate each other, and respond in a concentration dependant way to changing conditions without any central control.
- api 9y agoI always thought of it as a probability field of molecules.
- amelius 9y ago> have a receptor/channel/process/thing that only one precise 3d molecule can fit into But what if the molecule has an unexpected "tail" attached to it? How to prevent the process from getting stuck?
- lurker456 9y agoI imagine there are not many things with unexpected shapes at that level that aren't accounted for somehow. Anything that doesn't slot into it perfectly will get knocked away by collisions. Bad shapes do exist however (prions) and are a cause of diseases.
- AstralStorm 9y agoGenerally bulky substrates are inefficient and require additional catalysts for binding. (Typically kinases.) So something with an unexpected tail won't react. It will not occlude the receptor either because it won't bind with it reliably... These things are very, very precise.
- deleted 9y ago[deleted]