8 ms·

Experimental Cancer Treatment That Terminates Rogue Cells Could Arrive in 2017

126 points by DrScump 10y ago

chibuike 10y ago
i want to share this great and wonderful testimony to the general public on how i got cured from my sickness called (HEPATITIS B) by DR CHIBUIK healing herbal medicine , I have been suffering from (HEPATITIS B) for good 6 years now and I was almost going to the end of my life due to the constant pain, especially in my LIVER . all I have in my mind is let me just give up because life was no longer intestine to me any more but I just pray to God every day to accept my soul when ever I die, luckily to me , my kid sister ran to me that she found a doctor in the internet who can cure (HEPATITIS B, HERPES,CANCER, and HIV/AIDS ) she helped me out on everything, the great Dr CHIBUIK only ask for my Details and some items , so that he can prepare a Herbal medicine for me and send it to me in my country , which i did.. so after two days of getting the medicine and taking it as prescribe to me from him , I started getting more stronger my blood started flowing normally , i started experiencing changes all over my Body as the great DR CHIBUIK assured me that i should go for medical check up that i have been cured, so after some time i went to my doctor to confirmed if i have be finally healed , behold it was TRUE and i was very Happy ,so if you have HERPES , HEPATITIS B ,CANCER , HIV/AIDS or any kind of sickness YOU HAVE , you can contact him and, any illness get cured, i advice you all to contact himon Via mail at (doctorchibuike58@gmail.com) whatsapp number +2347052744530 Good luck
chibuike 10y ago
i want to share this great and wonderful testimony to the general public on how i got cured from my sickness called (HEPATITIS B) by DR CHIBUIK healing herbal medicine , I have been suffering from (HEPATITIS B) for good 6 years now and I was almost going to the end of my life due to the constant pain, especially in my LIVER . all I have in my mind is let me just give up because life was no longer intestine to me any more but I just pray to God every day to accept my soul when ever I die, luckily to me , my kid sister ran to me that she found a doctor in the internet who can cure (HEPATITIS B, HERPES,CANCER, and HIV/AIDS ) she helped me out on everything, the great Dr CHIBUIK only ask for my Details and some items , so that he can prepare a Herbal medicine for me and send it to me in my country , which i did.. so after two days of getting the medicine and taking it as prescribe to me from him , I started getting more stronger my blood started flowing normally , i started experiencing changes all over my Body as the great DR CHIBUIK assured me that i should go for medical check up that i have been cured, so after some time i went to my doctor to confirmed if i have be finally healed , behold it was TRUE and i was very Happy ,so if you have HERPES , HEPATITIS B ,CANCER , HIV/AIDS or any kind of sickness YOU HAVE , you can contact him and, any illness get cured, i advice you all to contact himon Via mail at (doctorchibuike58@gmail.com) whatsapp number +2347052744530 Good luck
piyush_soni 10y ago
Every once in a while we get to read similar news, that this 'selective' cancer killer is just arriving. Can someone more knowledgeable in this field comment whether this is just another clickbait article or not?
- yazbo_mcclure 10y ago
  Word.
- quickben 10y ago
  I am not a doctor, but from reading, there are many different cells and cancers (ways for these cells to misbehave but still not being killed by the body). As such, there is no singular 'cancer' and no singular 'cancer cure'. I may stand corrected by somebody more knowledgeable though.
  - mirsadm 10y ago
    Basically this. Even though there isn't one particular cure all solution, there are many more treatments available which are more effective than in the past.
  - berntb 10y ago
    The article discussed finding targets expressed by different cancers. The main problem is that a cancer can be quite heterogeneous. You really need multiple ways of killing a given cancer to be certain all is gone.
  - danielbarla 10y ago
    I'm probably not more knowledgeable, but from my understanding, most (all?) cancers are related in that they start as a single mutated cell which replicates in an aggressive way which leads to problems / death. Since it's a mutated cell, I can imagine extracting DNA from the cancerous area, and doing a diff against your "normal" DNA from elsewhere in your body. This would enable you to identify the difference / unique signature of the cancerous cells, kind of how a software antivirus looks for binary patterns in things that it scans. A mechanism like CRISPR could then be used to effectively target all instances of the mutated DNA / cells in your body, effectively wiping it out. I suspect this is ridiculously hand-wavy and oversimplified, but something like this might just be viable in our lifetimes.
cube00 10y ago
"Researchers have seen promising results so far, but there have also been tragic outcomes, with five patients dying while undergoing treatment during clinical trials this past year." It would be good if they could explain if that was caused by this new treatment or if the cancer was just too far advanced when treated.
- endymi0n 10y ago
  One hint inside was the strong side effects caused by the sudden cytokin toxin release due to the immune system metabolizing sometimes literally kilograms of cancer bacteria in a very short time.
  - knodi123 10y ago
    I was under the impression that for this reason, surgical resectioning was a necessary component of any viable approach for larger tumors.
- randcraw 10y ago
  In general, I suspect they know. If the death was caused by the drug the patient should show signs of abnormal immune response, like those of a cytokine storm: https://en.wikipedia.org/wiki/Cytokine_storm https://en.wikipedia.org/wiki/Cytokine_storm Also if the trial is allowed to continue, the study's monitors have decided that the study protocol wasn't violated, thus the drug wasn't 'misbehaving' to an unacceptable degree. Of course in late stage cancers with few/no further approved treatments, the decision of go vs no go on any course of action is often left to the patient and family, so 'unacceptable' can become a matter of will. From all I've read, administration of immunotherapies of all kinds is tricky and often leads to treatment complications often due to improper administation of the drug or inadequacies in monitoring the patients' response, since most doctors (like oncologists) are inexperienced in recognizing early signs of abnormal immune response.
  - ars 10y ago
    One research avenue would be using dialysis to remove cytokines. Ordinary dialysis does not remove much, but apparently there are some new filters that might work: https://www.karger.com/Article/FullText/369155 https://www.karger.com/Article/FullText/369155
baldfat 10y ago
As a dad who lost a son at 12 (2013) to bone cancer and as a brother who lost a sister at 15 (1996) to brain cancer I pray we will finally start funding pediatric cancer above the 4% rate of Federal Cancer Research and the 1% that American Cancer Society give to pediatric cancer research. There has been 4 whole new chemo treatments in the past 25 years for pediatric cancer patients compared to the frequency adult community. The issue is that every cell in children is growing. So in an older adult you can more easily focus growing cells. What works for children will work better for adults with the probability of less side effects. Those interested int he history of childhood cancer here is a good short history and why we are so helpful for immutheraphy. https://www.stbaldricks.org/blog/post/the-history-of-childhood-cancer-research/ https://www.stbaldricks.org/blog/post/the-history-of-childho...
- willismichael 10y ago
  I'm sorry to hear that. Cancer is horrible at any age, and I've never lost a family member as young as that to cancer, but I can only imagine that it must be even more horrible when its somebody you love that still would have had a whole life to live. We can only hope that child cancer research improves.
- fumar 10y ago
  As a brother who lost a sister to juvenile brain cancer as well, I have been searching for methods of helping the folks working on the problem. Outside of brain tumor non-profit foundations, have you found other channels to help? I am even thinking leaving ad-tech to work in bio-tech.
  - baldfat 10y ago
    St. Bladrick's is my favorite organization for funding for research and they actually helped fund a project that actually turned out to be a great new treatment for children with neroblastoma (Which has killed several of our friends' children). https://www.stbaldricks.org/blog/post/breaking-news-the-fda-approves-childhood-cancer-drug/ https://www.stbaldricks.org/blog/post/breaking-news-the-fda-...
- 10y ago
grater 10y ago
Plant based diet has been proven to slow and even reverse cancer, but there's no money in it. It will take time but slowly doctors are beginning to acknowledge that our biggest killers are the result of what you put in your body. edit: if anyone is interested, this is just one example: https://www.youtube.com/watch?v=0VX_oZBMSd4 https://www.youtube.com/watch?v=0VX_oZBMSd4
- deleted 10y ago
  [deleted]
- ohyoutravel 10y ago
  Please don't spread this absolute garbage.
  - leptoniscool 10y ago
    http://news.usc.edu/103972/fasting-like-diet-turns-the-immune-system-against-cancer/ http://news.usc.edu/103972/fasting-like-diet-turns-the-immun...
    - Ralfp 10y ago
      > according to a new USC-led study on mice
philsnow 10y ago
> Experimental Cancer Treatment That Terminates Rogue Cells Could Arrive in 2017 So, this gives cancer to members of terrorist cells? Or is that just a book somebody should write?
entee 10y ago
CAR-T-cell therapy is very promising but the salient quote here is this: "You need a good target, and that's probably the biggest obstacle to this kind of therapy," Cohen said. "We found a good target in leukemias and lymphomas. In solid tumors, it's been a bit more evasive." The target protein has to be exclusively associated with the type of cancer cell that the treatment is designed to kill. If it occurs in other types of cells, the results could be disastrous. Even successful immunotherapy treatments can destroy healthy cells, and researchers concede that achieving pinpoint accuracy remains a major challenge. Unfortunately, there have already been cases in which CAR-T patients have died. This is always the problem. It's always hard to have pinpoint accuracy in biology, and hopefully we'll get better at it but it's a hard slog. Also remember that while this is promising, remember that this approach is only going to work with surface-available targets. They won't work looking at cell-internal targets, which is obviously where a lot of cancer has gone wrong.
- digi_owl 10y ago
  That seems to be the basic problem when dealing with cancer. As it is a core behavior of our body run amok, it is damn hard to stop it without also killing the patient in the process.
kleiba 10y ago
"...or not." I've kinda developed a thing against headlines that seem to announce something great and wonderful, but in fact are purely speculative. One way to lure in readers.
perseusprime11 10y ago
Maybe this problem is too hard for humans to solve. We've spent a long time trying to crack this nut. I am more bullish on Machine learning solving this problem quickly in the next 5 years.
- aantix 10y ago
  Do you know of any specific efforts on that front?
  - perseusprime11 10y ago
    It is starting but most of them focus on predictions. Here is a paper that links to others but should give you an idea. https://www.ncbi.nlm.nih.gov/pubmed/25750696 https://www.ncbi.nlm.nih.gov/pubmed/25750696
cowardlydragon 10y ago
Are these the CRISPR based ones or a different flavor of TCell engineering?

126 points by DrScump 10y ago

i want to share this great and wonderful testimony to the general public on how i got cured from my sickness called (HEPATITIS B) by DR CHIBUIK healing herbal medicine , I have been suffering from (HEPATITIS B) for good 6 years now and I was almost going to the end of my life due to the constant pain, especially in my LIVER . all I have in my mind is let me just give up because life was no longer intestine to me any more but I just pray to God every day to accept my soul when ever I die, luckily to me , my kid sister ran to me that she found a doctor in the internet who can cure (HEPATITIS B, HERPES,CANCER, and HIV/AIDS ) she helped me out on everything, the great Dr CHIBUIK only ask for my Details and some items , so that he can prepare a Herbal medicine for me and send it to me in my country , which i did.. so after two days of getting the medicine and taking it as prescribe to me from him , I started getting more stronger my blood started flowing normally , i started experiencing changes all over my Body as the great DR CHIBUIK assured me that i should go for medical check up that i have been cured, so after some time i went to my doctor to confirmed if i have be finally healed , behold it was TRUE and i was very Happy ,so if you have HERPES , HEPATITIS B ,CANCER , HIV/AIDS or any kind of sickness YOU HAVE , you can contact him and, any illness get cured, i advice you all to contact himon Via mail at (doctorchibuike58@gmail.com) whatsapp number +2347052744530 Good luck

chibuike 10y ago

piyush_soni 10y ago

Every once in a while we get to read similar news, that this 'selective' cancer killer is just arriving. Can someone more knowledgeable in this field comment whether this is just another clickbait article or not?

yazbo_mcclure 10y ago
Word.
quickben 10y ago
I am not a doctor, but from reading, there are many different cells and cancers (ways for these cells to misbehave but still not being killed by the body). As such, there is no singular 'cancer' and no singular 'cancer cure'. I may stand corrected by somebody more knowledgeable though.
- mirsadm 10y ago
  Basically this. Even though there isn't one particular cure all solution, there are many more treatments available which are more effective than in the past.
- berntb 10y ago
  The article discussed finding targets expressed by different cancers. The main problem is that a cancer can be quite heterogeneous. You really need multiple ways of killing a given cancer to be certain all is gone.
- danielbarla 10y ago
  I'm probably not more knowledgeable, but from my understanding, most (all?) cancers are related in that they start as a single mutated cell which replicates in an aggressive way which leads to problems / death. Since it's a mutated cell, I can imagine extracting DNA from the cancerous area, and doing a diff against your "normal" DNA from elsewhere in your body. This would enable you to identify the difference / unique signature of the cancerous cells, kind of how a software antivirus looks for binary patterns in things that it scans. A mechanism like CRISPR could then be used to effectively target all instances of the mutated DNA / cells in your body, effectively wiping it out. I suspect this is ridiculously hand-wavy and oversimplified, but something like this might just be viable in our lifetimes.

cube00 10y ago

"Researchers have seen promising results so far, but there have also been tragic outcomes, with five patients dying while undergoing treatment during clinical trials this past year." It would be good if they could explain if that was caused by this new treatment or if the cancer was just too far advanced when treated.

endymi0n 10y ago
One hint inside was the strong side effects caused by the sudden cytokin toxin release due to the immune system metabolizing sometimes literally kilograms of cancer bacteria in a very short time.
- knodi123 10y ago
  I was under the impression that for this reason, surgical resectioning was a necessary component of any viable approach for larger tumors.
randcraw 10y ago
In general, I suspect they know. If the death was caused by the drug the patient should show signs of abnormal immune response, like those of a cytokine storm: https://en.wikipedia.org/wiki/Cytokine_storm https://en.wikipedia.org/wiki/Cytokine_storm Also if the trial is allowed to continue, the study's monitors have decided that the study protocol wasn't violated, thus the drug wasn't 'misbehaving' to an unacceptable degree. Of course in late stage cancers with few/no further approved treatments, the decision of go vs no go on any course of action is often left to the patient and family, so 'unacceptable' can become a matter of will. From all I've read, administration of immunotherapies of all kinds is tricky and often leads to treatment complications often due to improper administation of the drug or inadequacies in monitoring the patients' response, since most doctors (like oncologists) are inexperienced in recognizing early signs of abnormal immune response.
- ars 10y ago
  One research avenue would be using dialysis to remove cytokines. Ordinary dialysis does not remove much, but apparently there are some new filters that might work: https://www.karger.com/Article/FullText/369155 https://www.karger.com/Article/FullText/369155

baldfat 10y ago

As a dad who lost a son at 12 (2013) to bone cancer and as a brother who lost a sister at 15 (1996) to brain cancer I pray we will finally start funding pediatric cancer above the 4% rate of Federal Cancer Research and the 1% that American Cancer Society give to pediatric cancer research. There has been 4 whole new chemo treatments in the past 25 years for pediatric cancer patients compared to the frequency adult community. The issue is that every cell in children is growing. So in an older adult you can more easily focus growing cells. What works for children will work better for adults with the probability of less side effects. Those interested int he history of childhood cancer here is a good short history and why we are so helpful for immutheraphy. https://www.stbaldricks.org/blog/post/the-history-of-childhood-cancer-research/ https://www.stbaldricks.org/blog/post/the-history-of-childho...

willismichael 10y ago
I'm sorry to hear that. Cancer is horrible at any age, and I've never lost a family member as young as that to cancer, but I can only imagine that it must be even more horrible when its somebody you love that still would have had a whole life to live. We can only hope that child cancer research improves.
fumar 10y ago
As a brother who lost a sister to juvenile brain cancer as well, I have been searching for methods of helping the folks working on the problem. Outside of brain tumor non-profit foundations, have you found other channels to help? I am even thinking leaving ad-tech to work in bio-tech.
- baldfat 10y ago
  St. Bladrick's is my favorite organization for funding for research and they actually helped fund a project that actually turned out to be a great new treatment for children with neroblastoma (Which has killed several of our friends' children). https://www.stbaldricks.org/blog/post/breaking-news-the-fda-approves-childhood-cancer-drug/ https://www.stbaldricks.org/blog/post/breaking-news-the-fda-...
10y ago

grater 10y ago

Plant based diet has been proven to slow and even reverse cancer, but there's no money in it. It will take time but slowly doctors are beginning to acknowledge that our biggest killers are the result of what you put in your body. edit: if anyone is interested, this is just one example: https://www.youtube.com/watch?v=0VX_oZBMSd4 https://www.youtube.com/watch?v=0VX_oZBMSd4

deleted 10y ago
[deleted]
ohyoutravel 10y ago
Please don't spread this absolute garbage.
- leptoniscool 10y ago
  http://news.usc.edu/103972/fasting-like-diet-turns-the-immune-system-against-cancer/ http://news.usc.edu/103972/fasting-like-diet-turns-the-immun...
  - Ralfp 10y ago
    > according to a new USC-led study on mice

philsnow 10y ago

> Experimental Cancer Treatment That Terminates Rogue Cells Could Arrive in 2017 So, this gives cancer to members of terrorist cells? Or is that just a book somebody should write?

entee 10y ago

CAR-T-cell therapy is very promising but the salient quote here is this: "You need a good target, and that's probably the biggest obstacle to this kind of therapy," Cohen said. "We found a good target in leukemias and lymphomas. In solid tumors, it's been a bit more evasive." The target protein has to be exclusively associated with the type of cancer cell that the treatment is designed to kill. If it occurs in other types of cells, the results could be disastrous. Even successful immunotherapy treatments can destroy healthy cells, and researchers concede that achieving pinpoint accuracy remains a major challenge. Unfortunately, there have already been cases in which CAR-T patients have died. This is always the problem. It's always hard to have pinpoint accuracy in biology, and hopefully we'll get better at it but it's a hard slog. Also remember that while this is promising, remember that this approach is only going to work with surface-available targets. They won't work looking at cell-internal targets, which is obviously where a lot of cancer has gone wrong.

digi_owl 10y ago
That seems to be the basic problem when dealing with cancer. As it is a core behavior of our body run amok, it is damn hard to stop it without also killing the patient in the process.

kleiba 10y ago

"...or not." I've kinda developed a thing against headlines that seem to announce something great and wonderful, but in fact are purely speculative. One way to lure in readers.

perseusprime11 10y ago

Maybe this problem is too hard for humans to solve. We've spent a long time trying to crack this nut. I am more bullish on Machine learning solving this problem quickly in the next 5 years.

aantix 10y ago
Do you know of any specific efforts on that front?
- perseusprime11 10y ago
  It is starting but most of them focus on predictions. Here is a paper that links to others but should give you an idea. https://www.ncbi.nlm.nih.gov/pubmed/25750696 https://www.ncbi.nlm.nih.gov/pubmed/25750696

cowardlydragon 10y ago

Are these the CRISPR based ones or a different flavor of TCell engineering?