xyhopguy

8 ms·

31.
by xyhopguy 6y ago
It's a marvelous solution. But summers are better up north :)
32.
by xyhopguy 6y ago
waking up 2 hours before sunrise is painful
33.
by xyhopguy 6y ago
waking up two hours befor sunrise is miserable no matter how dark it stays. In anycase, for anyone in the northern US the sun would still set before or at 5:30.
34.
by xyhopguy 6y ago
in seattle that means sunrise at 9 and sunset at 515 in a place that's already hella dark. No thank you.
35.
by xyhopguy 6y ago
in the denser parts of portland it already is!
36.
by xyhopguy 6y ago
densify portland -> improve tax revenue -> improve transit. nyc certainly benefited from aristocrats and lax labor laws when building the subway, but this isnt something that is impossible for portland. trimet is already huge for a ci
37.
by xyhopguy 6y ago
Problems like the benchmark in the post are actually really simple to write in rust. They're all essentially streaming algorithms with some simple parsing. Fwiw rust has completely replaces cpp for high performant bioinfx code in my wo
38.
by xyhopguy 6y ago
whoops, I presumed you were asking about the math. My source is nytimes which pulls from the dataset you linked. https://www1.nyc.gov/assets/doh/downloads/pdf/imm/covid-19-d... Specifically has numb
39.
by xyhopguy 6y ago
they have a different lineage, but as I stated previously, no major functional mutations were observed.
40.
by xyhopguy 6y ago
That's a great point although obviously its very hard to estimate something that has a horizon of atleast a month. the bay area did shut down quite a bit earlier, it could be that the lack of deaths is simply due to a better response.
41.
by xyhopguy 6y ago
hm, care to explain more? that's exactly how I think about it. Total deaths in NYC attributable to covid (~20k) over the total population (8.5M) = ~.25%. In my mind this is a very easy lower bound to estimate, what am I missing here? I
42.
by xyhopguy 6y ago
afaik there havent we havent observed major functional mutations in the virus
43.
by xyhopguy 6y ago
people say that because .25% of the population in NYC are dead from covid. we dont see those numbers here -- if it was widespread in feb, what caused the discrepancy?
44.
by xyhopguy 7y ago
https://en.wikipedia.org/wiki/Odds_ratio odds of crash a => 97% => 3 / 100 odds of crash for b => 99.99% => 1 / 10000 improvement (odds ratio in this case) is then 300x = odds of crash for b &#x2F
45.
by xyhopguy 7y ago
all genes on X is a meaningless statement unless all genes are involved in X... if you read the paper the authors seemingly put quite a bit of effort into the rigor of their model. they used multiple validation cohorts, they controlled for
46.
by xyhopguy 7y ago
https://www.nature.com/articles/s41588-018-0147-3
47.
by xyhopguy 7y ago
have you ever looked at the test suites for Picard? All regression tests and the library is OO hell lols I was taught a decade ago that rolling your own in genomics isn't as bad of a decision as it seems.
48.
by xyhopguy 8y ago
I dont think this is settled -- I've seen world class swimmers do it both ways. Personally I find taking a long stroke after each breath more effective.
49.
by xyhopguy 8y ago
is trusting scientific authority the same thing really? Believing the theory of evolution is different than trusting that the $100 genome is around the corner... And unlike religious institutions, scientific institutions typically reflect t
50.
by xyhopguy 8y ago
California's neighbors to the north both have 1500+ establishments. Oregon isn't exactly big, but due to massive overproduction and no sales tax prices in Oregon are approaching sister crops like hop. Wtf is going on in California
51.
by xyhopguy 8y ago
Didn't stop Oregon. We've got 5x as many dispensaries as California and wayyyyyyyy less people. Oh and the prices are like 75% lower.
52.
by xyhopguy 8y ago
The tough part about this line of reasoning is you can't tease apart the discriminatory power of human knowledge from human vision. How good does our expert system need to be? How good do our sensors need to be? I'm not so sure th
53.
by xyhopguy 8y ago
I personally believe it's all integrated together. Sure methylation alone isnt going to effect the genotype of an individual, but thats not day it won't trigger some translocation event, expose LTRs, or some other mechanism of cha
54.
Liquid biopsies come of age: towards implementation of circulating tumour DNA(ncbi.nlm.nih.gov)
1 points by xyhopguy 8y ago|0 comments
55.
by xyhopguy 8y ago
Here's a nice review: https://www.ncbi.nlm.nih.gov/m/pubmed/28233803/ a biopsy from your peripheral plasma, opposed to solid tumor. A big issue in cancer medicine is it's super fucking hard to get a
56.
by xyhopguy 8y ago
I work in this space. The breakthrough will most likely come from computational biologists, not an external ML group. Liquid biopsy is close and that's the domain that reeeallly needs ML/AI in additional to strong mechanistic mode
57.
by xyhopguy 8y ago
Not if you understand mechanism. In reality the breakthrough will be biologists applying ML/AI, not the other way around. Domain and mechanistic knowledge are king.
58.
by xyhopguy 8y ago
> you should never allow other people to feed or pet it. Let children and elderly pet/feed and you suddenly have a well behaved protection dog.
59.
by xyhopguy 8y ago
Not really what im getting at. The pnw was developed later so I'd expect it to have less old money -- look at Oregon. The tech industry has certainly done a lot for the upper middle class in Seattle but the article is talking about peo
60.
by xyhopguy 8y ago
interesting that Seattle isn't anywhere to be found. I've always "felt" that the PNW had less old money. Anyone wanna feed my confirmation bias some more?

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