xaa

29 ms·

211.
by xaa 12y ago
The most convincing piece of evidence that telomeres are important in aging is that lack of telomerase (the protein that extends telomeres) or otherwise shortened telomeres causes progeroid (premature aging) disorders. But there are problem
212.
by xaa 12y ago
This is the standard antagonistic pleiotropy hypothesis. While there are some examples of specific proteins and pathways that work this way (beneficial in early life, detrimental in late life), it is far from certain that this is the key dr
213.
by xaa 12y ago
Sorry, really late reply. I fully appreciate that the type system imposes constraints that don't exist in Python or R. For my purposes in particular, and I think many people, I don't actually need a full-fledged data frame with he
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by xaa 12y ago
I work for a nonprofit medical research foundation in a lab that does bioinformatics, including some research on text mining information from biomedical journal articles, which might relate to your interest in linguistics. If you're si
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by xaa 12y ago
You are right that makefiles alone would be a bad fit for that situation. My approach would probably be to wrap the parameterizable parts in a script accepting arguments and run the combinations with GNU parallel. Possibly controlling the o
216.
by xaa 12y ago
Fellow bioinformatician here. I find it amusing to see all these projects reinventing pipes and makefiles much more verbosely and without language independence. The project in the OP, it goes without saying, will never be used by more than
217.
by xaa 12y ago
I want to love Julia. The core language is excellently designed and better than the alternatives, although the performance in practice is not nearly as good as the benchmarks would have you believe. String manipulation and building recurs
218.
by xaa 12y ago
Fewer and fewer institutions have tenured professorships these days, for three reasons I can think of: - The pension plans that typically go with long-term employment like tenured professorships are expensive. - Tenure gives professors a pr
219.
by xaa 12y ago
The data needed for searching (titles, abstracts, and other metadata), at least for biology-related articles, is already available in an XML dump from NIH. The public interface is called PubMed, so you can already search for Nature articles
220.
by xaa 12y ago
The real problem is that all of the major package managers require root, and usually you can't set the install prefix to a different folder than '/' (like for example '~/.local/'), without using chroo
221.
by xaa 12y ago
Traffic on the modern internet is almost totally unidirectional: it comes from big content providers and goes to consumers. When I pay my ISP for internet, I am paying them for the service of delivering the bits from the content providers t
222.
by xaa 12y ago
The CEO is implicitly claiming here that: a) given the current regulatory environment, the expansion would be profitable (since they're doing it), and b) if net neutrality were passed, there is a serious possibility that it would no lo
223.
by xaa 12y ago
No, they are seriously expanding fiber. Almost all of their new hires are trained on and working on building out fiber, and minimal resources are devoted to repairing copper. It would be a complete reversal of their strategy to stop expandi
224.
by xaa 12y ago
First, there's quite a difference between unprofitable and less profitable . Secondly, the internet is a utility. Utilities are regulated because they are essential and because they spawn natural monopolies. Interestingly, the pri
225.
by xaa 12y ago
> Any such make-work jobs proposal is obviously paying a premium over the actual value of the work (which is why the same job isn't available in the market already) Wouldn't the government be providing these "make-work&quo
226.
by xaa 12y ago
Direct link: https://wayback.stanford.edu/19911206000000/http://slacvm.sl... If you view source, it's utterly depressing that literally 98% of the page's code is dedicated to rendering Stanford&#x27
227.
by xaa 12y ago
This author has an unusual view on what constitutes his job. In my area, bioinformatics and life sciences, it is taken for granted that a professor or PI (principal investigator) will be performing very few or no experiments personally. Bec
228.
by xaa 12y ago
As a U.S. citizen, I have been extremely confused about why there has been no global response to Ukraine, especially from Europe. You seem to be implying that the EU does not care about Ukraine at all and is only responding to the crisis th
229.
by xaa 12y ago
Re #1, you are mostly correct that only philanthropic organizations will accept grants that are explicitly high-risk. But the way it works in practice is that most investigators write a NIH grant with conservative aims, then use the money h
230.
by xaa 12y ago
In addition to the other comments about taking care of yourself, and "soft" nootropics like piracetam, I have personally had excellent results with judicious use of amphetamines and nicotine. You have to know the risks (cardiovasc
231.
by xaa 12y ago
I live in an inexpensive part of the country, so salaries obviously vary based on that. $80-150K is the normal range for a PI here, but the sky's the limit if you can pull in a lot of grants/royalties. There are no set hours. You
232.
by xaa 12y ago
I am a researcher at a nonprofit research institution that does both basic and clinical research. When I work with MDs (or MD/PhDs), it is usually to analyze clinical and/or genomic data that they have collected from patients. Som
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by xaa 12y ago
I'm a PhD in biomedical sciences (biochem/bioinformatics), so I don't know directly about the MD side, although I work with MDs frequently. From what I have seen, physicians are generally not tech-savvy and are fairly behind-
234.
by xaa 12y ago
It is a good argument -- both are -- but they aren't the best argument, which is "we want to stop death". But we can't say that.
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by xaa 12y ago
It raises a lot of social and religious implications many would rather not think about. But we have learned to deal with it. Instead of saying you're studying aging, you say you're studying "age-associated disease X" (wh
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by xaa 12y ago
There's a great diversity in lifespan among organisms, which is a good clue, but the number of organisms that actually show no senescence is quite small, and they are all very distant from humans evolutionarily. Those few have been stu
237.
by xaa 12y ago
To be fair, people have been working on this problem for decades. It is only in the last 1-2 decades, though, that really large datasets (genetic and otherwise) have been available to turn understanding aging from a hard experimental proble
238.
by xaa 12y ago
There are many people who think that way too, but I think fred_durst seems to genuinely be more concerned about the effects on society. When I was considering careers, I concluded that there are 3 world-changing scientific problems: aging,
239.
by xaa 12y ago
First, there's no way you could offend me by anything you say. You've already done me a great service by explaining your views. I've met people with similar views before, but usually they're reluctant to describe them at
240.
by xaa 12y ago
(Can't reply directly) I'm extremely interested in understanding your perspective. See, I not only publicly support this, but as an aging researcher, I spend my days, nights, and weekends (right now, in fact) working towards this

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