whymauri

21 ms·

61.
by whymauri 3y ago
Sure, you can argue that coverage for lead optimization is an unintentional feature, not a bug of Markush. But you have to admit that the current system is leveraged in bad faith i.e. for hedging against generics, staggering patents to maxi
62.
by whymauri 3y ago
Not only bogus, but if you get a hit on a scaffold you can combinatorially modify that scaffold and file it with the patent. This effectively blocks the small permutation space around the drug from further investigation or development. Ther
63.
by whymauri 3y ago
At this point it feels like most brands are ripping me off; I'd be more interested in finding out which ones aren't, lol. Edit: this is what Carrefour is doing to an extent, but we don't have them in the US.
64.
by whymauri 3y ago
Caelid IRL.
65.
by whymauri 3y ago
Why not tackle inequality earlier in the funnel than college admissions? Better primary schooling and family resources? A college admission lottery doesn't seem to be a serious solution.
66.
by whymauri 3y ago
This was my reaction, as well. So visually and structurally unremarkable, it's actually elegant in how 'un-exotic' it is. Love to see it!
67.
by whymauri 3y ago
Central America is their largest growing sector IIRC.
68.
by whymauri 3y ago
>completely decriminalized? Does decriminalized mean something I'm not aware of? Do you mean that prescriptions are not criminalized? Use? Possession?
69.
by whymauri 3y ago
The main reason an academic career seemed infeasible to was because I would never comfortably afford the housing. I went broke my first summer living alone and decided to become a software engineer.
70.
by whymauri 3y ago
The fact my dad grew up in Venezuela when it was the 4th wealthiest nation in the world per capita (granted, Europe was recovering from WW2) blows my mind. It was still top 20 by the 70s. [0] [0] https://www.nationmaster.com&#x2F
71.
by whymauri 3y ago
I did the math for my aunt recently: she pays more in rent and car expenses living in suburban South Florida (Kendall) for the same square footage I get in Cambridge, MA. Living paycheck to paycheck sandwiched between a super Walmart and th
72.
by whymauri 3y ago
I live in Cambridge. All places I've lived in Cambridge were within a 5 minute walk of a publicly accessible pool. Before I had a car for outdoor climbing, I took the commuter rail to see local towns or got a ZipCar and split the cost
73.
by whymauri 3y ago
Since Fall of 2022, there's been a negative spiral within the MBTA. Primarily due to poor maintenance leading to: service cuts, full shutdown of certain lines, and the highest percentage of slow zones in recent history. Here's a g
74.
by whymauri 3y ago
My favorite thing about the MBTA is it's one of the least piss-smelling subway system in the U.S. I wish it moved like the MTA, though lol. I might be willing to make that tradeoff... maybe.
75.
by whymauri 3y ago
Tylenol is a crazy drug to me. Every medicinal chemist I worked with told me it would not be approved today due to toxicity conferns.
76.
by whymauri 3y ago
I followed this strategy + parallelized developing preliminary ideas and wrapped up in 3 years, 11 months with 100/100 Hope. If it only it was that easy! Haha
77.
by whymauri 3y ago
There's a network effect at Caltech, which does not practice AA, because it's so small. Basically, if you get into Caltech without AA, chances are you got into an equally good university with AA. However, it's clear to the ou
78.
by whymauri 3y ago
I grew up next to Tamiami Airport, now Miami Executive Airport. The number of overconfident private flight incidents/crashes was wild, enough to make the neighborhood unhappy and eventually get one of the flight schools shut down. [0]
79.
by whymauri 3y ago
Hotel bars are in a liminal space where some of the best bars in the world are in big city hotels, but also some of the most disappointing bars. Hard to know without searching in advanced. I'm not sure I would just walk in when the pri
80.
by whymauri 3y ago
Exactly. It's not about the absolute percentage of people using third-party services, it's about the users that matter: power users, moderators, and especially content posters/creators.
81.
by whymauri 3y ago
Monetization and growth go hand-in-hand. I'm an old.reddit.com user (even on MoWeb, I know I'm a psycho), but the way people talk about Apollo is like it's absolutely superior to the current Reddit app. If I were Reddit, and
82.
by whymauri 3y ago
Does anyone know if Reddit has explored acquiring/hiring the Apollo team before? And/or why not?!
83.
by whymauri 3y ago
Colombia, parce.
84.
by whymauri 3y ago
The only professor I've seen get a standing ovation (not including retirement lectures) was Patrick Winston during one of the last lectures of Artificial Intelligence. Or, maybe How to Speak. Memory is a bit fuzzy.
85.
by whymauri 3y ago
I took his applied linear algebra course as an undergrad. Such a kind man and so passionate about teaching. Very much "in the know" on modern ML, like LMs, and he found ways to tie the fundamentals to current topics. Always happy
86.
by whymauri 3y ago
Python is the least of my concerns with Tensorflow... especially TF 1.0. What a mess it was, and kinda still is.
87.
by whymauri 3y ago
You could probably fit all the people who fit the last criteria in the same room (chemistry side is probably the bottleneck, especially drugs which is a effectively a specialization).
88.
by whymauri 4y ago
Good chalk on a good board should sound like a light hiss, not a lot of 'ffffff'.
89.
by whymauri 4y ago
Wild to think about the potentially countless records etched on wood that are completely lost to time.
90.
by whymauri 4y ago
I was able to get better performance by always providing the prior sequence of moves and forcing ChatGPT to also respond with the sequence of moves up until its move. Edit: I told the model that if the sequence was wrong or illegal, it forf

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