wgolsen

6 ms·

1.
by wgolsen 5y ago
It’s unfortunate that Shoshana Zuboff‘S writing is so bad, because I think some of her ideas are important. If anyone is interested in this topic I would recommend her interview on Econ Talk [1]. Russ Roberts makes a valiant effort and is p
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by wgolsen 5y ago
An interim analysis of Grail’s Pathfinder study [1] suggests a PPV of 43% [2]. This may be a mixed population of their high and normal risk cohorts - it’s not clear to me from the abstract. They call this a conservative estimate, which seem
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by wgolsen 5y ago
My favorite response to this and related objections to ending aging (such as “what about the dictators”): imagine a scenario where humans did not age, but still had the problems of “gerontocracy” and dictatorships. Would you propose subject
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by wgolsen 5y ago
> there's no significant process that turns trees into sequestered carbon for longer than the trees' lifespan. There is of course lumber, which can sequester CO2 for decades or hundreds of years. Lumber sequestration currently
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by wgolsen 5y ago
The lung epithelium has also recently been transfected in humans (see Translate Bio cf drug; this and similar vehicles can deliver editing tools)
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by wgolsen 5y ago
In my opinion, and it seems in the NPR editor’s opinion, the most exciting angle to this story isn’t the cure of one relatively rare disease (TAA), but rather the seemingly imminent cure of many/most inherited diseases which affect cel
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by wgolsen 5y ago
When administered IV, most LNPs of this type are highly selective for hepatocytes. This edit cannot be passed on as no germ cells will be transfected.
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by wgolsen 5y ago
The concentration of cell free DNA in blood plasma is generally in the nanograms/mL range, meaning most cfDNA assays will require at least a ~mL of plasma input for sufficient sensitivity / reproducibility. We aren’t quite at the
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by wgolsen 5y ago
One version of what you are describing is called an antibody-drug conjugate. There are about a dozen ADCs approved and many more in various stages of development
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by wgolsen 6y ago
You could do reverse transcription and sequencing to confirm the presence of the full length spike protein. That should tell you with pretty high confidence that it’s authentic. But the really interesting “biopunk novel plot” future would b
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by wgolsen 9y ago
What years? I visited Dr. Whittaker and David Gump in ~2010 to present an analysis of their business plan. At the time I was thoroughly impressed with the tech/team and equally unimpressed with the business case Gump had made. I hope t