vikramkr

31 ms·

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by vikramkr 2y ago
So that's already happened. It's called an algae bloom. They don't necessarily fix their own nitrogen though, we fix it for them and dump it into oceans (we're quite a bit better at it than nature at this point). Biologi
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by vikramkr 2y ago
Eh, that's really hard to do and fertilizer is cheap you just zap some air with electricity and You're chilling. Plus legumes have the better version figured out imo - symbiotic bacteria instead of having to support a whole new or
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by vikramkr 3y ago
I'm not sure that's the right question. It's more, is there a chance at all of anyone figuring it out, and given the enormous scale of the security risk that poses, we should start proactively mitigating those threats. If fus
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by vikramkr 3y ago
I mean, if you're just going to ignore the core point then I guess feel free. The disconnect seems to be that you think it's somehow reflects poorly on Elon that he's good at his job! Being self serving is good, controlli
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by vikramkr 3y ago
I - that's a truly stunning mindset I don't have words. Why would you consider the market leader of a market a reliable source for information on the market? Maybe this is obvious to me coming from a world where all banks have the
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by vikramkr 3y ago
You're really gonna take a statement from a CEO that it's important for the government to intervene in order to protect his profits at face value? Elon's made some stupid decisions in the past but I don't think he's
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by vikramkr 3y ago
Calling it a nightmare scenario is quite the overdramatic description of a successful experiment that validated a core prediction of the standard model
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by vikramkr 3y ago
Man, they really tried to use a different denominator for every one of those percentages huh. Total granted approval, total with 5 years follow up, total converted to approval (which includes some with less than 5 year follow up). Edit: oh
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by vikramkr 3y ago
The better way of thinking about it is that this progress is allowing us to shift away from the idea of 'general' cancer or identifying cancer by tissue of origin to instead start identifying it by more useful and actionable featu
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by vikramkr 3y ago
They are: https://www.fda.gov/news-events/press-announcements/fda-appr... https://en.wikipedia.org/wiki/Tissue-agnostic_cancer_drug If by "game" you mean rigorous regulatory process
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by vikramkr 3y ago
The press release is obviously overselling (also remission != cure), but that's separate from the statistics of the study and it's design and the significance of the results. It's almost always a safe bet to just ignore press
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by vikramkr 3y ago
What's funny is that the paper has the statistics. The original point is sort of valid in that narrowly speaking, there's probably been other cancer trials with similar response rates. Sticking with that specific argument then yea
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by vikramkr 3y ago
Edit - also, you should go and look up the rates of spontaneous remission for colorectal cancer (e.g. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10273780/ ). We're talking about 12 patients with stage
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by vikramkr 3y ago
The targeting here is definitely the point, its the core hypothesis in the abstract. In general this increased targeting ability has been enormously powerful in solving the response rate problem you mentioned. Fundamentally the problem isnt
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by vikramkr 3y ago
Yep that's part of the advance here. Identifying what those subsets are. This drug went on to be approved for mismatch repair deficient endometrial cancers in 2023
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by vikramkr 3y ago
The cell therapies are really expensive and struggling with manufacturing costs, mabs like these are priced what they are because of market forces.
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by vikramkr 3y ago
Depends on if that mechanism of action works for the particular exact set of mutations that the given tumor has (every cancer is essentially unique). Part of the success of the work in that paper is identifying specific markers that indicat
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by vikramkr 3y ago
Checkpoint inhibitors are immunotherapies. The checkpoints they're inhibiting are immune checkpoints.
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by vikramkr 3y ago
For context, this study was in 2022, this drug had received accelerated approval in 2021 and was fully approved by the FDA in 2023 for mismatch repair deficient endometrial cancer. ( https://www.fda.gov/drugs/resources-i
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by vikramkr 3y ago
That also doesn't really happen right now and I'm not sure a summary is an improvement whoever writes it. You can just run that article through an llm yourself to get a summary - comment threads are useful for discussions with oth
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by vikramkr 3y ago
Actual paper which is actually open access: https://pubmed.ncbi.nlm.nih.gov/28017605/ On a seperate note, at some point university PR departments should take a moment to reflect on just how much responsibility they bea
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by vikramkr 3y ago
All of them? It's a backdoor into Linux to gain unauthorized access to computers that even specifically only works for that attackers specific private key. We have trial by jury where I guess you could argue that this carefully crafted
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by vikramkr 3y ago
As a sanity check, attempted crime is still crime, so not a lawyer but part B isn't exactly ambiguous here: https://www.law.cornell.edu/uscode/text/18/1030 In terms of a plausible business model - I mean
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by vikramkr 3y ago
Do you have a source for the claim that this isn't a crime because it didn't succeed? As a sanity check, checking the plain text of the CFAA, it covers attempted hacking as you'd expect. So distributing a system with a backdo
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by vikramkr 3y ago
Is there some weird loophole or something I'm missing here? Otherwise, I'm not exactly sure how hacking wouldn't be illegal.
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by vikramkr 3y ago
Good point. The core of what i'm trying to get at with that statement is - in many of the regions where ecological restoration is a topic of conversation, stakeholders with power over restoration would only recently have begun to inter
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by vikramkr 3y ago
The land can sustain them fine, that's just what it's like to live near bears. Tons of places are like that - you get used to it lol don't worry. There was a Tom Scott video on work folks are doing to develop bear resistant t
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by vikramkr 3y ago
If you use it as a transitive word and people understand what you meant then yes it can be a transitive verb - that's the only criteria. In this case I think most people would understand what you mean so yes.
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by vikramkr 3y ago
Why isn't that a fair comparison? If that's an important factor in their purchase decision that's completely fair. You can compare whatever you want when you're evaluating subjective criteria for a purchase decision - an
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by vikramkr 3y ago
It's nice for personal use which is what I think it was built for, has some nice frontend options too. The tooling around it is nice, and there are projects building in rag etc. I don't think people are intending to deploy days se

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