vikramkr

64 ms·

811.
by vikramkr 6y ago
vaccines against COVID have already been developed. They already exist. Designing them took a couple of weeks. What takes time is testing them to make sure they are safe and effective. The cold causing coronaviruses would also have to be te
812.
by vikramkr 6y ago
Technically, making those things easier also makes SSTOs work since optimized multi stage orbits let us get to the moon where SSTOs are the default option to get off of the lunar surface. In a sense SSTOs are part of the current earth to mo
813.
by vikramkr 6y ago
giving everyone a cold virus is a vaccine by definition. It's a biological preparation to provide active acquired immunity. Trying to make up artificial distinctions between this and that doesn't make giving everyone the cold not
814.
by vikramkr 6y ago
Deploying a coronavirus to immunize against covid is a vaccine by definition and deciding to not call it a vaccine as a matter of syntax doesn't make the ADE risk go away
815.
by vikramkr 6y ago
Maybe, but thats basically developing a new vaccine, and in the time it takes to test that out and make sure it's safe and effective, we'd already have other vaccines on the market that might be more likely to be effective. Theres
816.
by vikramkr 6y ago
You may note I used the word exclusively. TADs are hardly the end all be all of gene function. Epigenetics has more to do with gene regulation than function, and TADs aren't remotely close to the dominant force in epigenetics either. G
817.
by vikramkr 6y ago
Since when is the universal way to identify a gene its locus? The locus is just the position of a given gene in a particular chromosome. The function of a gene is not exclusively tied to chromosomal location. If I take the sequence for SHH
818.
by vikramkr 6y ago
They're tags and you end up with multiple names for the same gene. They might as well be replaced with an arbitrary string of numbers- those are equally easy to do a quick Google scholar or pubmed search with. You don't lose anyth
819.
by vikramkr 6y ago
I've been in the room when deciding what to call a gene that the lab had just characterized/identified as interesting for the publication they were working on, and let's just say that making it easy to catalog and find the ge
820.
by vikramkr 6y ago
A lot of people are attacking excel in this thread, just remember to give a fair share of the blame to people naming genes as well. These are meaningless names and changing them is frankly easier than changing a feature in excel (that the f
821.
by vikramkr 6y ago
But we didn't accept them as they are. We looked at two options, change excel or change gene names, and picked the one most likely to solve the problem. Gene names mean nothing anyway. We're going from random letters that mean not
822.
by vikramkr 6y ago
so your pocket PCR is a thermocycler, which is a thing that heats and cools samples of liquid to set temperatures for set times for a programmed number of cycles. Tube gets hot, tube gets cold, makes a few stops along the way, repeat. Now
823.
by vikramkr 6y ago
That's a qPCR machine, which is an entirely different beast in terms of capability and cost than your usual thermocycler. $5000 is an amazing deal on a qPCR machine. A piece of new qPCR kit is gonna run you 30-50 thousand dollars m
824.
by vikramkr 6y ago
No, you can use a thermocycler for reverse transcription. In fact, you need one to do rtPCR, and I don't see why this cycler wouldn't be able to do that. And to clarify, I didn't say the device detects a sequence. I said it l
825.
by vikramkr 6y ago
Initiatives like OpenPCR went a long way towards opening up DIY biology to the responsible amateur and making it easier to start a DIY bio hackerspace for a region. Glad to see them featured on HN.
826.
by vikramkr 6y ago
It doesn't sequence, it amplifies DNA/RNA (through reverse transcription) and lets you detect a particular sequence or produce more of a sequence you want to use for downstream steps
827.
by vikramkr 6y ago
The EU banned the use of methanol in windshield washer fluid[1], and the sooner the US does the same, the better. Methanol is very toxic. You don't spread windshield washer fluid all over your hands and breathe in the vapors for a reas
828.
by vikramkr 6y ago
They mention that they are adding them to import alert in order to stop them from being legally imported into the US
829.
by vikramkr 6y ago
Why is that "curious?" They clearly state they're putting these on import alert to prevent them from entering the country, it's not like they're hiding anything. If they put out a blanked statement it would impact a
830.
by vikramkr 6y ago
Reading into this - flywheel apparently stole patented ideas from peloton including streaming on demand exercise classes? And that's why their service is shutting down? How is that supposed to be a protectable/patentable concept?
831.
by vikramkr 6y ago
I'm not inverting the meaning. I used that idiom precisely because it conveys the meaning that going after the two in the bush can leave you empty handed. I think this is a terrible idea and that antagonizing your existing users on the
832.
by vikramkr 6y ago
You didn't read the comment correctly. Wizardry is from the perspective of the tech aware but not tech saavy users.
833.
by vikramkr 6y ago
Who do you think that statement is targeting in their marketing? Clearly not full techies that would probably pick up that it's BS. Your everyday non-tech person wouldn't care about this service anyway since who cares what a javas
834.
by vikramkr 6y ago
I think the reason is probably what you mentioned - very few people are starting large Perl projects nowadays. And I think they'd like that to not be the case anymore by making it attractive to newcomers. Feels a bit like a bird in the
835.
by vikramkr 6y ago
That was a mistype, thanks for catching that. I meant 25, but I haven't kept up with the last quarter so I have no idea what it looks like with all the recent insanity, so that might be pretty far off as well
836.
by vikramkr 6y ago
What you brought up above in this thread is how expensive the acquisition looks as a multiple of earnings. That multiplier is the price of the company vs the earnings for the company, which is literally just a simplified P/E ratio that
837.
by vikramkr 6y ago
Nvidia's own pe ratio is around 80 it looks like. Its not actually that insane. Overvalued? Maybe. But all this is saying is that basically, you think that your current required rate of return minus your expected growth rate for ARM is
838.
by vikramkr 6y ago
This is more from a increasing adoption of arm industry wide perspective as people begin writing code on and optimizing code for ARM machines. Could trickle over into increased adoption by other companies and other sectors.
839.
by vikramkr 6y ago
But its definitely not in any financial metrics. If you own walmart for a year, you'll make around 4 billion, while if you own Google, you'll make around 7. And Google is likely going to be growing faster than Walmart.
840.
by vikramkr 6y ago
Free cash flow is better than revenue - you can play around with accruals in unsavory ways that are harder to pull off with cash.

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