vibrio

6 ms·

31.
by vibrio 10mo ago
Slightly different point but many bacteria in us right now also make lipopolysaccharide (LPS). If it were purified and injected iv, the LPS in me could probably kill me 1000 x over.
32.
by vibrio 10mo ago
I agreee with the caution. I am not endocrinologist enough to guess what may happen and when. Because of the level of variably in all that is being experimented with, my guess is there may be a slower burn rather than explosion of odd toxic
33.
by vibrio 10mo ago
Will side effects for hormonal and gene therapy approaches be shaken out in just 3-5 years? For gene therapy, the rare blood cancers associated with car-t or bluebirdbio suggest maybe not. Maybe they remain rare, but as scale and flexibilit
34.
by vibrio 10mo ago
“Viruses” have a very broad feature set-beyond evoking Batman, it seems like a lot of details need to be hammered out here, even residually chlorinated water can be problematic in maintaining titers. IMO, These days, public health policy (
35.
by vibrio 10mo ago
AIDS has been treatable for a few decades, with good progression getting it to developing world and some towards a cure. That said, some of this recent progress has been impeded due to differing beliefs of some current governmental regul
36.
by vibrio 10mo ago
This made me think of the "Institute for one world health" . It came out as a non-profit pharmaceutical company in the mid 2000's. Victoria Hale was the founder-it got her a MacArthur fellowship. It is focuses(focused?) on g
37.
by vibrio 10mo ago
also, Elephants have a much higher copy number of a gene called p53/ It codes a protein that acts to force suicide in cells that have damaged DNA (think from UV light, cigarette smoke, age, etc). In cancer this is a common 'early
38.
by vibrio 11mo ago
As a bit of a Flight Aware addict, well done.
39.
by vibrio 11mo ago
If I mowed 2 acres of lawn dad would give me a stack of quarters. It didn’t take me long to realize that a fraction of that mowing time spent playing Defender would consume those quarters. I still loved playing it, but valuable perspective.
40.
by vibrio 11mo ago
Yes thank you. The concept of Natural Selection has a lot more dependencies and complications than typically attributed. Especially for a complex outcome like “intelligence” or economic success.
41.
by vibrio 1y ago
Any specific reason? Are you concerned about Purity of Essence?
42.
by vibrio 1y ago
This. They don’t get paid much, or much glory if any, but overall they are smart and hard working and are eager to have rational and data driven discussions about the programs they oversee. Current status is heartbreaking.
43.
by vibrio 1y ago
It’s much less fun if you have a loved one, say an aggressive autoimmune disease. Do not recommend.
44.
by vibrio 1y ago
This is a summary of my view. The danger is an overly opinionated “leader” with strong opinions has veto power over expert fda review teams, the system fails and decisions are not made on data and consensus but rather ideology and self imp
45.
by vibrio 1y ago
“He had the temerity to reject a drug that had lousy data…” Was that data really “lousy”? (Referencing the REPL data?) Was it a trial design issue? (which he has very strong and unconventional opinions on) Is it the role of his position to
46.
by vibrio 1y ago
True. and a screwdriver is as just a valid tool as a hammer. Though their use isn’t always interchangeable .
47.
by vibrio 1y ago
The bane of most gene therapy research is lack of persistence. With how serious and morbid HD is, I’d guess patients will take their chances.
48.
by vibrio 1y ago
I am really enjoying the game. It is really hard on my eyes for some reason. Other color options and increasing the size of the operators (+\-) seem like things that may help .
49.
by vibrio 1y ago
"Forced to throw away" biases is strong. If run well, RCTs surely help manage potential biases, but it does not eliminate them. The slides saw available on X-itter didn't show a Consort diagram (accounting of patient count be
50.
by vibrio 2y ago
Seems like promising new science in an area that is an under appreciated health risk. in a perfect world, the science should be the hard part. But where we have been for a while, the economics of antibiotic drug development and commercializ
51.
by vibrio 2y ago
Agreed with your point. Satire relies on Truth for context. At the moment, both are critically wounded, if not dead.
52.
by vibrio 2y ago
What is 'smart'?
53.
by vibrio 2y ago
Edited to zero
54.
by vibrio 2y ago
Yeah. 1930s Poland and Ukraine would like to Thank Joesph for the humanitarian-driven altruism. Molotov–Ribbentrop really set Adolph straight. /s
55.
by vibrio 2y ago
My guess is there would be a strong selection against impulsive non-experts. That’s on my “No-MacGyver” list with garage door springs and AC unit capacitors .
56.
by vibrio 2y ago
Thank you. It’s been a while since I read some Doonesbury. Now, I might go on a bender.
57.
by vibrio 2y ago
Nice. I did that for 2024. It was a secondary goal/effect of aiming to limit phone time when “idle”. When I carry the cube around, screen time goes down. I’m not at 30 secs yet but < 1 min often.
58.
by vibrio 2y ago
Check your assumptions.
59.
by vibrio 2y ago
Oxygen is a great book that covers a lot of this from geology to microbiology to chemistry.
60.
by vibrio 2y ago
Yup. I tried that and got scolded by teachers because the lines are all off (big margin at the bottom. Thin red line on the wrong side. ) I tried to get the pads with the spiral at the top- that works.

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