vibrio

28 ms·

361.
by vibrio 10y ago
Isn't a significant proprtion of the products Big Pharma sells were developed by start ups? based on my undestanding it is hard to claim that Pharma like Sanofi and Pfizer have good track records at internally discovering and bringing
362.
by vibrio 10y ago
The relevant IP isn't the active pharmaceutical ingredient but the formulation and delivery method, and that appears to be out to 2035. http://www.accessdata.fda.gov/scripts/cder/ob/results_produc... h
363.
by vibrio 10y ago
First: I don't disagree with you about price gouging and the need for a solution. i spend time awake at night thinking about it. Considering COGS in Biologics drugs pricing is a logical fallacy. The $10 is irrelevant. You have to amor
364.
by vibrio 10y ago
Please pardon if my comment came off as uncivil. My intent was to illustrate the potential ambiguity of ethics in national security issues by quoting a speech of Col. Jessup (Jack Nicholson) from a "A Few Good Men". I saw the mess
365.
by vibrio 10y ago
Probably, but from an economics perspective, i'm not sure who will push that position. There seems to be plenty of Lenders willing to take a chance with someone offering a lower down payments and in turn charge them a higher rate.
366.
by vibrio 10y ago
...and we have to assume you are a master agent leading a crack team of saboteurs.
367.
by vibrio 10y ago
As a former life scientist, I completely agree also. Things do get repeated. If the findings aren't robust, scientists cut bait and move on. This knowledge is shared informally, for certian. This "Formalzation" of the exper
368.
by vibrio 10y ago
The more similar they are genetically, the easier it should be to define and characterize the differences that are responsible for morphology, behavior, and diseases that run among breeds, no?
369.
by vibrio 10y ago
While it may seem esoteric to some, I believe significant effort should be put into the sequencing and analysis of dogs genetics. Their selective breeding is truly the greatest genetic experiment ever performed: from to Chihuahuas and Great
370.
by vibrio 10y ago
You've constructed a nice straw man. "pirates* demand for years" "pirates have decided" Pirates* and pirates are likely different groups. Arrr, but ye shall remember...pirates will be pirates matey!!
371.
by vibrio 10y ago
I agree, but broadly stated, the path doesn't generally train good scientists. The MD/PhD is more like a MD/MS. They frequently are pushed through 'phd' more rapidly under the eye of Med School deans and to optimize
372.
by vibrio 10y ago
I think the implication was that an MRI for something else might have removed it much more quickly and less precisely
373.
by vibrio 10y ago
Agreed that for most tumor types targeting single antigens is a fool's errand, but the claim that "here is absolutely no fitness cost" for mutational evasion seem like is an overstatement. This is clearly false when using bac
374.
by vibrio 10y ago
I agree with you that the down voting is silly, as s/he makes some good points, but suspect the down voting was in reaction to the tone of the comment. If one was holding a lab meeting and a comment arose in that tone, one could image
375.
by vibrio 10y ago
The term "microbiome" has become tired and 'frothy'. I advocate using the unglamorous but old school term "microbial flora" however futile and unimportant my effort may be. How about a smart toilet rather than
376.
by vibrio 10y ago
With the advent of the internet, the marginal cost of producing and distributing such content has dropped by orders of magnitude since the 1990's. One would expect in a competitive, healthy economic system, some of this productivity ga
377.
by vibrio 11y ago
i came here to say this. i'd recommend getting a used accounting book and/or Schaum's guide to have on a shelf as one reviews financials. Also, when i narrow the field down to a small group of companies to evaluate and pick
378.
by vibrio 11y ago
Well put. Carl Woese figured this out back when sequencing 20 base pairs was a feat (now 20 million is routine). This paper seems to be fine-focus of his concepts using tools he'd only have dreamed of using in the 1970's. He'
379.
by vibrio 11y ago
I agree that some level of 'greed' is good just like other animal-level motivations (anger, lust, etc). The problem is that unchecked they can be consuming make for poor decisions in the long view. Plus, they don't need to be
380.
by vibrio 11y ago
"Assuming any government is going to better spend money than private enterprise is one of the funniest things I've read today." As someone that works in the same industry as Pfizer (and Valeant), yes it is true that sometime